Limited Heart Rate Reduction Promotes Cardiac Regeneration Through Stimulation of the Metabolic Pattern Switch

2021 ◽  
Author(s):  
Jing Tan ◽  
Ming Yang ◽  
Haiping Wang ◽  
Conghui Shen ◽  
Maoxiong Wu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiac Regeneration ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Metabolic Pattern ◽  
Stimulation Of

Comparison of Transient Heart Rate Reduction Associated with Acupuncture Stimulation in Supine and Sitting Subjects

2003 ◽  
Vol 21 (4) ◽  
pp. 133-137 ◽  
Author(s):  
Kenji Imai ◽  
Hiroshi Kitakoji
Keyword(s):  
Heart Rate ◽  
Supine Position ◽  
Sympathetic Nerve Activity ◽  
Sitting Position ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Nerve Activity ◽  
The Difference ◽  
The Right ◽  
Stimulation Of

We investigated the difference in transient heart rate reduction associated with brief acupuncture in 20 healthy subjects at rest in a supine and in a sitting position. After the subjects had been at rest for about 20 minutes, acupuncture needling using the sparrow-pecking method, in which the needle is moved vertically lifting and thrusting, was performed for one minute at the Shousanli point on the right forearm (LI10). The procedure was carried out with the subjects in a supine position and in a sitting position. The position for stimulation of each subject, either supine or sitting, was selected at random, and on different days. The results showed that the average heart rate reduction associated with stimulation in supine subjects was 3.6±0.19 (mean ± standard error {SE}) beats per minute (bpm), while that for sitting subjects was about 7.0±1.07 (mean ± SE) bpm, indicating that stimulation reduces heart rate to a greater degree in subjects who are sitting (p<0.05, Mann-Whitney test). These results would be consistent with a mechanism involving reduced sympathetic drive to the heart, as sympathetic nerve activity has more influence on the heart rate in the sitting than in the supine position.

Role of Heart Rate Reduction in the Management of Myocarditis

2018 ◽  
Vol 24 (3) ◽  
pp. 365-378 ◽  
Author(s):  
Chen Guang-Yi ◽  
Ge Li-Sha ◽  
Li Yue-Chun
Keyword(s):  
Heart Rate ◽  
Nitrosative Stress ◽  
Ventricular Remodeling ◽  
Animal Experiments ◽  
Viral Myocarditis ◽  
Protective Effects ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Beneficial Effects ◽  
Biological Technique

The morbidity of myocarditis demonstrates an upward tendency by years, is commonly defined as the inflammation of myocytes and is caused by multiple factors. With the development of the molecular biological technique, great breakthroughs in the diagnosis and understanding of pathophysiological mechanisms of myocarditis have recently been achieved. Several questions remain unresolved, however, including standard treatment approaches to myocarditis, which remain controversial and ambiguous. Heart rate, as an independent risk factor, has been shown to be related to cardiac disease. Recent studies also show that the autonomic nervous system is involved in immunomodulatory myocarditis processes. Heart rate reduction treatment is recommended in myocarditis based on a number of animal experiments and clinical trials. It is possible that heart rate-lowering treatments can help to attenuate the inflammatory response and myocyte injury and reverse ventricular remodeling. However, how to execute the protective effects of heart rate reduction on myocarditis is still not clear. In this review, we discuss the pathogenesis and pathophysiological process of viral myocarditis and propose heart rate lowering as a therapeutic target for myocarditis, especially in light of the third-generation β-blockade carvedilol and funny channel blocker ivabradine. We also highlight some additional beneficial effects of such heart rate reduction agents, including anti-inflammatory, antioxidation, anti-nitrosative stress, anti-fibrosis and antiapoptosis properties.

scholarly journals Heart Rate Reduction Strategy Improves Survival in Children with Severe Dilated Cardiomyopathy

2021 ◽  
Vol 40 (4) ◽  
pp. S122
Author(s):  
R. Adorisio ◽  
E. Mencarelli ◽  
N. Cantarutti ◽  
L. Amato ◽  
M. Ciabattini ◽  
...  
Keyword(s):  
Heart Rate ◽  
Dilated Cardiomyopathy ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Reduction Strategy

Heart rate reduction via selective ‘funny’ channel blockers

2007 ◽  
Vol 7 (2) ◽  
pp. 208-213 ◽  
Author(s):  
A BUCCHI ◽  
A BARBUTI ◽  
M BARUSCOTTI ◽  
D DIFRANCESCO
Keyword(s):  
Heart Rate ◽  
Channel Blockers ◽  
Heart Rate Reduction ◽  
Rate Reduction

scholarly journals Heart rate reduction and exercise performance in recent onset heart failure with reduced ejection fraction: arguments for beta-blocker hypo-response

2015 ◽  
Vol 70 (5) ◽  
pp. 565-572
Author(s):  
Frederik H. Verbrugge ◽  
Jeroen Vrijsen ◽  
Jan Vercammen ◽  
Lars Grieten ◽  
Matthias Dupont ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Ejection Fraction ◽  
Beta Blocker ◽  
Exercise Performance ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Reduced Ejection Fraction ◽  
Recent Onset

Pharmacologic Heart Rate Reduction: Effect of a Novel, Specific Bradycardic Agent on the Heart

1998 ◽  
Vol 46 (02) ◽  
pp. 63-69 ◽  
Author(s):  
A. Granetzny ◽  
U. Schwanke ◽  
C. Schmitz ◽  
G. Arnold ◽  
D. Schäfer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Bradycardic Agent ◽  
Reduction Effect

scholarly journals Should We Consider Heart Rate Reduction in Cardiac Transplant Recipients?

2012 ◽  
Vol 36 (2) ◽  
pp. 68-73 ◽  
Author(s):  
Baskar Sekar ◽  
William R. Critchley ◽  
Simon G. Williams ◽  
Steven M. Shaw
Keyword(s):  
Heart Rate ◽  
Cardiac Transplant ◽  
Heart Rate Reduction ◽  
Transplant Recipients ◽  
Rate Reduction

scholarly journals Chronic Heart Rate Reduction Facilitates Cardiomyocyte Survival After Myocardial Infarction

2010 ◽  
Vol 293 (5) ◽  
pp. 839-848 ◽  
Author(s):  
Rong-Lin Zhang ◽  
Lance P. Christensen ◽  
Robert J. Tomanek
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Cardiomyocyte Survival
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