scholarly journals Should We Consider Heart Rate Reduction in Cardiac Transplant Recipients?

2012 ◽  
Vol 36 (2) ◽  
pp. 68-73 ◽  
Author(s):  
Baskar Sekar ◽  
William R. Critchley ◽  
Simon G. Williams ◽  
Steven M. Shaw
Keyword(s):  
Heart Rate ◽  
Cardiac Transplant ◽  
Heart Rate Reduction ◽  
Transplant Recipients ◽  
Rate Reduction

Effects of Heart Rate Reduction with Ivabradine on Cardio- Pulmonary Capacity in Heart Transplant Recipients

2012 ◽  
Vol 94 (10S) ◽  
pp. 940
Author(s):  
U. K. Radunski ◽  
M. Schlüter ◽  
S. Ohdah ◽  
A. von Stritzky ◽  
T. Deuse ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Transplant ◽  
Heart Rate Reduction ◽  
Transplant Recipients ◽  
Rate Reduction ◽  
Heart Transplant Recipients

Role of Heart Rate Reduction in the Management of Myocarditis

2018 ◽  
Vol 24 (3) ◽  
pp. 365-378 ◽  
Author(s):  
Chen Guang-Yi ◽  
Ge Li-Sha ◽  
Li Yue-Chun
Keyword(s):  
Heart Rate ◽  
Nitrosative Stress ◽  
Ventricular Remodeling ◽  
Animal Experiments ◽  
Viral Myocarditis ◽  
Protective Effects ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Beneficial Effects ◽  
Biological Technique

The morbidity of myocarditis demonstrates an upward tendency by years, is commonly defined as the inflammation of myocytes and is caused by multiple factors. With the development of the molecular biological technique, great breakthroughs in the diagnosis and understanding of pathophysiological mechanisms of myocarditis have recently been achieved. Several questions remain unresolved, however, including standard treatment approaches to myocarditis, which remain controversial and ambiguous. Heart rate, as an independent risk factor, has been shown to be related to cardiac disease. Recent studies also show that the autonomic nervous system is involved in immunomodulatory myocarditis processes. Heart rate reduction treatment is recommended in myocarditis based on a number of animal experiments and clinical trials. It is possible that heart rate-lowering treatments can help to attenuate the inflammatory response and myocyte injury and reverse ventricular remodeling. However, how to execute the protective effects of heart rate reduction on myocarditis is still not clear. In this review, we discuss the pathogenesis and pathophysiological process of viral myocarditis and propose heart rate lowering as a therapeutic target for myocarditis, especially in light of the third-generation β-blockade carvedilol and funny channel blocker ivabradine. We also highlight some additional beneficial effects of such heart rate reduction agents, including anti-inflammatory, antioxidation, anti-nitrosative stress, anti-fibrosis and antiapoptosis properties.

scholarly journals Heart Rate Reduction Strategy Improves Survival in Children with Severe Dilated Cardiomyopathy

2021 ◽  
Vol 40 (4) ◽  
pp. S122
Author(s):  
R. Adorisio ◽  
E. Mencarelli ◽  
N. Cantarutti ◽  
L. Amato ◽  
M. Ciabattini ◽  
...  
Keyword(s):  
Heart Rate ◽  
Dilated Cardiomyopathy ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Reduction Strategy

Heart rate reduction via selective ‘funny’ channel blockers

2007 ◽  
Vol 7 (2) ◽  
pp. 208-213 ◽  
Author(s):  
A BUCCHI ◽  
A BARBUTI ◽  
M BARUSCOTTI ◽  
D DIFRANCESCO
Keyword(s):  
Heart Rate ◽  
Channel Blockers ◽  
Heart Rate Reduction ◽  
Rate Reduction

scholarly journals Heart rate reduction and exercise performance in recent onset heart failure with reduced ejection fraction: arguments for beta-blocker hypo-response

2015 ◽  
Vol 70 (5) ◽  
pp. 565-572
Author(s):  
Frederik H. Verbrugge ◽  
Jeroen Vrijsen ◽  
Jan Vercammen ◽  
Lars Grieten ◽  
Matthias Dupont ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Ejection Fraction ◽  
Beta Blocker ◽  
Exercise Performance ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Reduced Ejection Fraction ◽  
Recent Onset

Pharmacologic Heart Rate Reduction: Effect of a Novel, Specific Bradycardic Agent on the Heart

1998 ◽  
Vol 46 (02) ◽  
pp. 63-69 ◽  
Author(s):  
A. Granetzny ◽  
U. Schwanke ◽  
C. Schmitz ◽  
G. Arnold ◽  
D. Schäfer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Bradycardic Agent ◽  
Reduction Effect
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