Analysis of the Effect of the “Back to Sleep” Campaign on Sudden Unexpected Death in One Year Olds

2021 ◽  
Author(s):  
Toshimasa Obonai ◽  
Masayuki Itoh ◽  
Kazuhiko Morikawa ◽  
Hiroshi Nishida
Keyword(s):  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
One Year ◽  
Back To Sleep

scholarly journals Post-Mortem Echocardiography as a Guide to Cardiac Autopsy—A Worthwhile Concept?

2010 ◽  
Vol 4 ◽  
pp. CMC.S5676
Author(s):  
J. Ker ◽  
L. Du Toit-Prinsloo ◽  
WFP. Van Heerden ◽  
G Saayman
Keyword(s):  
Case Report ◽  
Cause Of Death ◽  
Diagnostic Yield ◽  
Sudden Unexpected Death ◽  
Post Mortem ◽  
Unexpected Death ◽  
Diagnostic Modality ◽  
One Year

Sudden and unexpected death in the young is a common and worldwide problem. Sudden, unexpected death in infancy (SUDI), clinically unexpected death in an infant between one week and one year of age, affects around 1 in 1000 infants. Autopsy will reveal a specific cause of death in only one third of cases. This has led to various ancillary examinations in an effort to increase the diagnostic yield of the autopsy. In this case report it is suggested that another diagnostic modality, that of the post-mortem echocardiogram might be a worthwhile concept to explore.

ECG-Patterns of Focal Epileptic Seizures, the Role in Sudden Unexpected Death in Epilepsy: A Prospective Long-Term Study

2019 ◽  
Author(s):  
Svetlana Serdyuk ◽  
Karapet V. Davtyan ◽  
Sergey G. Burd ◽  
Oksana M. Drapkina ◽  
Sergey A. Boytsov ◽  
...  
Keyword(s):  
Epileptic Seizures ◽  
Sudden Unexpected Death ◽  
Unexpected Death ◽  
Term Study ◽  
Long Term Study

A forensic autopsy case: sudden unexpected death due to cardiac inflammatory myofibroblastic tumor

2021 ◽  
pp. 101931
Author(s):  
Shoken Suzuki ◽  
Maki Ohtani ◽  
Yuhei Matsuo ◽  
Makoto Yoshida ◽  
Akiteru Goto ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Forensic Autopsy ◽  
Sudden Unexpected Death ◽  
Autopsy Case ◽  
Unexpected Death

scholarly journals Differential Methylation in the GSTT1 Regulatory Region in Sudden Unexplained Death and Sudden Unexpected Death in Epilepsy

2021 ◽  
Vol 22 (6) ◽  
pp. 2790
Author(s):  
Steffan Noe Christiansen ◽  
Stine Bøttcher Jacobsen ◽  
Jeppe Dyrberg Andersen ◽  
Marie-Louise Kampmann ◽  
Linea Christine Trudsø ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cardiac Tissue ◽  
Heart Diseases ◽  
Regulatory Region ◽  
Differential Methylation ◽  
Sudden Unexpected Death ◽  
Diagnostic Challenge ◽  
Unexpected Death ◽  
Sudden Unexplained Death ◽  
Unexplained Death

Sudden cardiac death (SCD) is a diagnostic challenge in forensic medicine. In a relatively large proportion of the SCDs, the deaths remain unexplained after autopsy. This challenge is likely caused by unknown disease mechanisms. Changes in DNA methylation have been associated with several heart diseases, but the role of DNA methylation in SCD is unknown. In this study, we investigated DNA methylation in two SCD subtypes, sudden unexplained death (SUD) and sudden unexpected death in epilepsy (SUDEP). We assessed DNA methylation of more than 850,000 positions in cardiac tissue from nine SUD and 14 SUDEP cases using the Illumina Infinium MethylationEPIC BeadChip. In total, six differently methylated regions (DMRs) between the SUD and SUDEP cases were identified. The DMRs were located in proximity to or overlapping genes encoding proteins that are a part of the glutathione S-transferase (GST) superfamily. Whole genome sequencing (WGS) showed that the DNA methylation alterations were not caused by genetic changes, while whole transcriptome sequencing (WTS) showed that DNA methylation was associated with expression levels of the GSTT1 gene. In conclusion, our results indicate that cardiac DNA methylation is similar in SUD and SUDEP, but with regional differential methylation in proximity to GST genes.

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