Joint-utilization Bootstrapping Among a Portfolio of Early-stage Start-ups

2020 ◽  
Author(s):  
Vahid Behroozabadi
Keyword(s):  
Early Stage ◽  
Start Ups

Three Views of a Train Wreck

2016 ◽  
Author(s):  
Michael Kinch
Keyword(s):  
Public Health ◽  
Research And Development ◽  
Venture Capital ◽  
Food Chain ◽  
Early Stage ◽  
Health Benefits ◽  
Federal Spending ◽  
Moore’S Law ◽  
Government Grants ◽  
Start Ups

Despite and arguably because of the enormous public health benefits arising from the introduction of new medicines, the industry is in the midst of crisis. We detail in this chapter the decline in research and development efficiency, which has been termed “Eroom's Law,” a playful inversion of the bettern known Moore's Law of Computing. An explanation of declining efficiency follows as is a brief summary of some remedies taken by many biopharmaceutical entities, including the abandonment of therapeutics targeting particularly difficult indications such as Alzheimer's disease and antibiotics. We also convey how the industry has developed into a sort of food chain, with smaller companies and government grants supporting the earliest stages of research, which are then acquired by medium-sized companies, which in turn are consolidated into large companies. This food chain is fundamentally in doubt based on shrinking Federal spending on research combined with a decline in venture capital support for early-stage start-ups.

Start-Ups and Spin-Offs in Biotechnology Sector in Poland

Biotechnology ◽  
2019 ◽  
pp. 1293-1321
Author(s):  
Anna Białek-Jaworska ◽  
Renata Gabryelczyk
Keyword(s):  
Business Models ◽  
Stock Exchange ◽  
Early Stage ◽  
Global Strategy ◽  
Third Party ◽  
Start Up ◽  
Warsaw Stock Exchange ◽  
Business Line ◽  
Definition Of ◽  
Start Ups

This chapter concerns the subject of research-developmental activity of biotech spin-offs in Poland with particular reference to their strategy, determinants of their development and determinants of their financial standing. In the chapter, the authors analyse the determinants of biotech spin-offs and start-ups development in Poland in the light of the research commercialisation cooperation on the universities-business line. The literature overview contains the definition of a process for the commercialisation of the results of research and development (R&D) activity and components of companies' business models. The chapter defines key activities in the development of business models in the context of the commercialisation process and the life cycle of the company, especially at the start up and early stage. Quality-quantitative analysis includes the business models of seven biotechnology spin-offs traded on the alternative market of the Warsaw Stock Exchange, especially the structure of their intellectual capital, R&D expenses in relation to received subsides and grants, third-party shares in start up equity, and the ability to realise the “Go Global” strategy.

scholarly journals The early growth of start-ups: innovation matters. Evidence from Italy

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Raffaele Fiorentino ◽  
Sergio Longobardi ◽  
Alessandro Scaletti
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Firm Growth ◽  
Ad Hoc ◽  
Early Stage ◽  
New Ventures ◽  
Objective Measure ◽  
Content Type ◽  
Start Up ◽  
Start Ups

PurposeDespite the relevance of innovation in entrepreneurship literature, empirical research on the innovation-performance relationship in start-ups is underdeveloped and shows controversial results. To bridge this gap, the aim of this paper is to investigate the role of innovativeness on new venture performance in the early stage of the life cycle.Design/methodology/approachRegression modelling and propensity score matching are used to reveal systematic differences in growth between innovative start-ups (ISUPs) and non-innovative start-ups. We use an ad hoc dataset obtained through merging the financial database AIDA with data from administrative sources (Italian Chambers of Commerce and the Italian Ministry for Economic Development).FindingsThe results show that differences in growth can be explained by the different levels of innovativeness in new ventures. Moreover, unlike in prior studies, the innovation inputs matter more than innovation outputs. Indeed, the results support the idea that innovation policies can contribute to maximising the potential of start-ups.Practical implicationsThe findings provide suggestions for policy makers and entrepreneurs to help firms configure ex ante appropriate actions to support the growth of new ventures in the start-up stage.Originality/valueThis study is the first to use the new objective measure of start-up innovation, available from the Italian LD 221 register. Second, different types of innovation are investigated as antecedents of firm growth. Third, we employ propensity score matching, which favours revealing systematic differences in growth between ISUPs and non-innovative start-ups. Fourth, the results of our study are the first to offer evidence on the effectiveness of the new Italian sustaining ISUPs policy.

scholarly journals What do growing early-stage digital start-ups look like? A mixed-methods approach

2021 ◽  
pp. 102427
Author(s):  
Anastasia Griva ◽  
Dimosthenis Kotsopoulos ◽  
Angeliki Karagiannaki ◽  
Efpraxia D. Zamani
Keyword(s):  
Mixed Methods ◽  
Early Stage ◽  
Mixed Methods Approach ◽  
Start Ups

scholarly journals Design practices for strategic innovation in start-ups

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Daphna GLAUBERT ◽  
Zarina CHARLESWORTH ◽  
Nathalie NYFFELER ◽  
Luc BERGERON ◽  
Luc BERGERON
Keyword(s):  
Early Stage ◽  
Self Report ◽  
Initial Development ◽  
Design Practices ◽  
Strategic Innovation ◽  
Stage Of Development ◽  
Start Up ◽  
Product Service ◽  
Working Together ◽  
Start Ups

This paper looks at the use of design practices in start-up firms for the creation of strategic advantage through product/service innovation. Start-ups face non-negligible challenges during the early-stage of development. The research questions examined to what extent design practices can provide the leverage needed to face these challenges. A 4-day Innovation by Design Challenge workshop provided the field for the research carried out. Participants were start-up firms each working together with two designers to form six teams. Methods used included: observation for the mapping of team activities; a short self-report questionnaire and; pre- and post-workshop semi-directed interviews with the start-ups. The findings support the idea that design practice integration into the initial development of a start-up can indeed provide a lever for success and provide the start-up with the strategic vision needed to go through the early-stage and bring their products/services to market successfully.

scholarly journals Health Software Product or Software as Medical Device

2021 ◽  
Vol 7 (2) ◽  
pp. 644-647
Author(s):  
Tabea Lukas ◽  
Keywan Sohrabi ◽  
Volker Gross ◽  
Michael Scholtes
Keyword(s):  
Medical Device ◽  
Early Stage ◽  
Medical Product ◽  
Physiological Data ◽  
Software Products ◽  
Regulatory Affairs ◽  
The Right ◽  
Start Ups ◽  
Medical Device Regulation ◽  
Young Entrepreneurs

Abstract The number of software products in the field of health and medicine increases excessively. Self-tracking, fitness, health advice, dose calculation, and analysis of physiological data - apps are popular and commonly used. Some of the products are affected by the medical device regulation, consciously or unconsciously. For young entrepreneurs, it is difficult to recognize and understand the distinction between software as medical product and health software products. A product-related orientation guide could help start-ups to understand the difference and to find the right strategy for placing their product on the market. All relevant information were collected and analyzed. Input came from a systematic literature research, an evaluation of the CHARISMHA study and a consideration of the medical device regulation as well as the relevant standards (e.g. IEC 62304 and IEC 82304). The guide was adapted to the particular situation of start-ups and microenterprises, inter alia having regard to missing regulatory affairs competences. A product-related orientation guide for young entrepreneurs was developed, which helps to identify whether products are affected by the medical device regulation or not. The guide uses a few simple questions, and it allows the entrepreneurs to estimate the related effort. Furthermore, it provides an overview of relevant standards and needed competences for the chosen path. The guide brings certainty and can help young entrepreneurs to identify the upcoming workload at an early stage. Due to the decision tree concept, it is easy to adapt the product-related strategy and see the consequences. This might help entrepreneurs to find the right strategy for placing their product on the market. Nevertheless, field testing with the guide is necessary to validate its benefit.

Money for female entrepreneurs does not grow on trees: start-ups’ financing implications in times of COVID-19

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
David Villaseca ◽  
Julio Navío-Marco ◽  
Ricardo Gimeno
Keyword(s):  
Gender Gap ◽  
Early Stage ◽  
Supply And Demand ◽  
Entrepreneurial Activity ◽  
Extensive Literature ◽  
Negative Effects ◽  
Female Entrepreneurs ◽  
Content Type ◽  
Public Organisations ◽  
Start Ups

Purpose The purpose of this paper is to understand women’s approaches to acquiring financial and other resources is essential for closing the entrepreneurship gender gap. In nearly 40% of economies, women’s early-stage entrepreneurial activity is half or less than half of that of men’s. Design/methodology/approach Even when there is extensive literature on female entrepreneurs, the authors review the findings through a Coronavirus Disease 2019 (COVID-1)9 crisis lens, trying to find new perspectives and solutions. With the approach of a systematic review of 4,520 publications on financing topics related to female entrepreneurs, various sources of financing available to female entrepreneurs are considered: bootstrapping, banks, business angels, venture capital and crowdfunding. Findings Identifying potential gender bias both on the supply and the demand side of financing, this research highlights new directions in encouraging female entrepreneurship and gives guidelines to public organisations on how to foster advanced forms of financing for female entrepreneurs in COVID-19 times. Social implications The COVID-19 pandemic has posed an unprecedented challenge for economies and companies. Female entrepreneurs are the ones who have been hit harder, as they overcome pre-existing barriers, such as lack of access to finance, lack of networks and mentors and gendered priorities, among others. Without ensuring gender policies to counter these incremental negative effects, the authors face the risk of widening the gender gap. Originality/value Regarding previous systematic reviews of literature, this paper focusses on a specific challenge, how women entrepreneurs finance their activity, with a double vision: supply and demand of money.

The Corporate Social Network (CSN) in SME's

2017 ◽  
pp. 33-52
Author(s):  
Isabelle Choquet ◽  
Jacques Folon
Keyword(s):  
Social Networks ◽  
Social Network ◽  
Knowledge Sharing ◽  
Collective Intelligence ◽  
Early Stage ◽  
Efficient Tool ◽  
Start Up ◽  
The Creation ◽  
Corporate Social ◽  
Start Ups

The authors intend to demonstrate that corporate social networks (CSN) are a very efficient tool for SME's and start-ups, since their early launch. They will immediately create an interactive structure and a culture of collective intelligence. The chapter aims at revealing how SMEs or start-ups are able to capture the opportunities provided by CSNs, perceived as proximity social networks. The research investigates if the use of CSN at the launch of the SME promotes the development of a collective intelligence culture, but also if several CSN may coexist within the same structure according to the needs encountered: “above-the-flow” approach (dialogue, exchanges) or “in the flow” approach (integration of workflow and document). The authors strongly believe that CSN has to be introduced by a web entrepreneur at the early stage of creation of his start-up, because it supports the scaling of the business, allowing the creation of a knowledge sharing culture, making the knowledge available inside the company.

Journey's end: a dynamic framework of entrepreneurial processes and capitals relating to early stage business exit

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Richard Hanage ◽  
Pekka Stenholm ◽  
Jonathan M. Scott ◽  
Mark A.P. Davies
Keyword(s):  
Case Studies ◽  
Early Stage ◽  
Theory Building ◽  
Cross Sectional ◽  
Content Type ◽  
Dynamic Framework ◽  
Longitudinal Dynamic ◽  
Start Up ◽  
New Business ◽  
Start Ups

PurposeThe purpose of this paper is to respond to the call by McMullen and Dimov (2013) for a clearer understanding of entrepreneurial journeys by investigating the entrepreneurial capitals and micro-processes of seven young early stage entrepreneurs who all exited their businesses within 3 years of start-up.Design/methodology/approachThe authors analysed empirical data from concurrent in-depth interviews which generated rich longitudinal case studies. Theory-building then led to a proposed “Longitudinal Dynamic Process Framework” of entrepreneurial goals, processes and capitals.FindingsThe framework builds on prior studies by integrating entrepreneurial processes and decisions into two feedback loops based on continuous review and learning. It thereby enhances understanding of the dynamics of new business development and unfolds the early stage ventures entrepreneurs' business exits.Research limitations/implicationsThe findings are based on a small purposive sample. However, the main implication for research and theory is showing how the entrepreneurial capitals are dynamic and influenced by entrepreneurs' environment, and also separating entrepreneurs' personal issues from their business issues.Practical implicationsThe findings challenge some assumptions of policymakers and offer new insights for practitioners and early stage entrepreneurs. These include having more realistic case-studies of the entrepreneurial journey, recognizing the need to be agile and tenacious to cope with challenges, understanding how capitals can interact in complementary ways and that entrepreneurial processes can be used to leverage them at appropriate stages of the start-ups.Originality/valueThe concurrent longitudinal analysis and theory-building complements extant cross-sectional studies by identifying and analysing the detailed processes of actual business start-ups and exits. The proposed framework thereby adds coherence to earlier studies and helps to explain early stage entrepreneurial development, transformation of capitals and business exit.

Performance Drivers of Digital Ventures

2021 ◽  
Author(s):  
Timo B. Johnson
Keyword(s):  
Early Stage ◽  
Added Value ◽  
Performance Impact ◽  
Digital Platforms ◽  
Empirical Basis ◽  
Alternative Technologies ◽  
Significant Performance ◽  
Performance Drivers ◽  
Start Ups

Entrepreneurs and investors face crucial decisions to positively influence the financing and exit success of digital start-ups. This book analyses the most significant performance drivers of digital ventures. The author assesses, first, the early-stage financing method, second, the choice of business focus and, third, the motives for syndication. In three studies, he thereby identifies the performance impact of practitioners’ fundamental decisions on a broad empirical basis, thus integrating research from finance and entrepreneurship. He provides insights into the effects of experience and the added value of all common investor types, compares digital platforms to alternative technologies and examines the influence of investor syndicates.

Sign in / Sign up

Export Citation Format

Share Document