Multi-Sided Platform Strategy, Taxation, and Regulation: A Quantitative Model and Application to Facebook

2020 ◽  
Author(s):  
Seth Benzell ◽  
Avinash Collis
Keyword(s):  
Quantitative Model

Quantitative Model-Based Image Analysis of NuMa Distribution Links Nuclear Organization with Cell Phenotype

2001 ◽  
Vol 7 (S2) ◽  
pp. 578-579
Author(s):  
David W. Knowles ◽  
Sophie A. Lelièvre ◽  
Carlos Ortiz de Solόrzano ◽  
Stephen J. Lockett ◽  
Mina J. Bissell ◽  
...  
Keyword(s):  
Image Analysis ◽  
Mammary Epithelial Cells ◽  
Nuclear Organization ◽  
Critical Role ◽  
Quantitative Model ◽  
Mammary Epithelial ◽  
Cell Phenotype ◽  
Proliferating Cells ◽  
Mitotic Apparatus ◽  
Model Based

The extracellular matrix (ECM) plays a critical role in directing cell behaviour and morphogenesis by regulating gene expression and nuclear organization. Using non-malignant (S1) human mammary epithelial cells (HMECs), it was previously shown that ECM-induced morphogenesis is accompanied by the redistribution of nuclear mitotic apparatus (NuMA) protein from a diffuse pattern in proliferating cells, to a multi-focal pattern as HMECs growth arrested and completed morphogenesis . A process taking 10 to 14 days.To further investigate the link between NuMA distribution and the growth stage of HMECs, we have investigated the distribution of NuMA in non-malignant S1 cells and their malignant, T4, counter-part using a novel model-based image analysis technique. This technique, based on a multi-scale Gaussian blur analysis (Figure 1), quantifies the size of punctate features in an image. Cells were cultured in the presence and absence of a reconstituted basement membrane (rBM) and imaged in 3D using confocal microscopy, for fluorescently labeled monoclonal antibodies to NuMA (fαNuMA) and fluorescently labeled total DNA.

Cooperative selection of action in tapping: A quantitative model

1991 ◽  
Author(s):  
Jonathan Vaughan ◽  
David A. Rosenbaum ◽  
Cathleen Moore
Keyword(s):  
Quantitative Model ◽  
Selection Of

Acyl-Enzymes as Thrombolytic Agents in Dog Models of Venous Thrombosis and Pulmonary Embolism

1984 ◽  
Vol 51 (02) ◽  
pp. 248-253 ◽  
Author(s):  
R J Dupe ◽  
P D English ◽  
R A G Smith ◽  
J Green
Keyword(s):  
Pulmonary Embolism ◽  
Side Effects ◽  
Venous Thrombosis ◽  
Active Site ◽  
Acute Pulmonary Embolism ◽  
Quantitative Model ◽  
Beagle Dog ◽  
Thrombosis Model ◽  
Derivatives Of

SummaryA quantitative model of venous thrombosis in the beagle dog is described. The model was adapted to permit ageing of isolated experimental clots in vivo. A model of acute pulmonary embolism in this species is also described. In the venous thrombosis model, infusion of streptokinase (SK) or SK-activated human plasmin gave significant lysis but bolus doses of SK. plasmin complex were ineffective. Active site anisoylated derivatives of SK. plasminogen complex, SK-activated plasmin and activator-free plasmin were all active when given as bolus doses in both models. At lytic doses, the acyl-enzymes caused fewer side-effects attributable to plasminaemia than the corresponding unmodified enzymes.

Service Quality Of Industrial Parks In The View Of Foreign Direct Investment Firms

2019 ◽  
Vol 118 (11) ◽  
pp. 552-562
Author(s):  
Nguyen Thi Ngan ◽  
Bui Huy Khoi
Keyword(s):  
Foreign Direct Investment ◽  
Service Quality ◽  
Direct Investment ◽  
Reliability And Validity ◽  
Quantitative Model ◽  
Industrial Park ◽  
Industrial Parks ◽  
Average Variance ◽  
Composite Reliability

This research aims to assess the service quality of industrial parks (IP) in the view of FDI (foreign direct investment) firms in Vietnam. Data was collected from 270 FDI firms in Vietnam - Singapore Industrial Parks (VSIP) in Vietnam. The proposed research model was based on researches on service quality. Cronbach's Alpha Average Variance Extracted (Pvc),rho (ρA), and Composite Reliability (Pc) tested the reliability and validity of the scale. The analysis results showed that four factors were affecting the servicequality of industrial park in Vietnam being tangibleof VSIP, reliability of VSIP, the empathyof FDI investors, and their assurance. The responsivenessof VSIP did not affect the servicequality of the industrial park. Contents of the article focus on two main issues: the analysis framework of the quantitative model and implicating results todevelop the industrial park services. The limitation of the research was only in VSIP in Vietnam.

A Practical Approach to Quantitative Model Risk Assessment

2020 ◽  
Author(s):  
Carole Bernard ◽  
Rodrigue Kazzi ◽  
Steven Vanduffel
Keyword(s):  
Risk Assessment ◽  
Quantitative Model ◽  
Practical Approach ◽  
Model Risk

Quantitative Model of FIB Deposition

2007 ◽  
Vol 9 (8) ◽  
pp. 708-711 ◽  
Author(s):  
F. Rüdenauer ◽  
G. Mozdzen ◽  
W. Costin ◽  
E. Semerad
Keyword(s):  
Quantitative Model

Electron transfer sensitized photolysis of 'onium salts

1988 ◽  
Vol 66 (2) ◽  
pp. 319-324 ◽  
Author(s):  
R. J. DeVoe ◽  
M. R. V. Sahyun ◽  
Einhard Schmidt ◽  
N. Serpone ◽  
D. K. Sharma
Keyword(s):  
Electron Transfer ◽  
Flash Photolysis ◽  
Laser Flash Photolysis ◽  
Laser Flash ◽  
Quantitative Model ◽  
Intersystem Crossing ◽  
Single Electron Transfer ◽  
Onium Salts ◽  
Encounter Complex ◽  
Back Electron Transfer

We have studied the anthracene-sensitized photolyses of both diphenyliodonium and triphenylsulphonium salts in solution using both steady-state and laser flash photolysis techniques. Photoproducts, namely, phenylated anthracenes along with iodobenzene or diphenylsulphide, respectively, are obtained from both salts with quantum efficiencies of ca. 0.1 at 375 nm. We infer the intermediacy of diphenyliodo and triphenylsulphur radicals formed by single electron transfer from the singlet-excited anthracene. We have developed a quantitative model of this chemistry, and identify the principal sources of inefficiency as back electron transfer, which occurs at nearly the theoretically limiting rate, intersystem crossing from the initially formed sensitizer–'onium salt encounter complex, and in-cage radical recombination.

scholarly journals Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations.

Genetics ◽  
1989 ◽  
Vol 121 (1) ◽  
pp. 139-151
Author(s):  
M K Uyenoyama
Keyword(s):  
Major Histocompatibility Complex ◽  
Quantitative Model ◽  
Major Histocompatibility ◽  
Single Population ◽  
T Complex ◽  
Histocompatibility Complex ◽  
Single Antigen ◽  
Complete Independence ◽  
Specific Antigens ◽  
T Haplotype

Abstract A quantitative model is developed to explore the effects of prezygotic and postzygotic incompatibility on the origin and maintenance of associations between the major histocompatibility complex (MHC) and the t-complex in the mouse. Incompatibility is represented by a reduction in the rate of conception or gestation of offspring derived from sperm bearing MHC antigens in common with the mother. Incompatibility encourages the evolution of associations from a state of complete independence between the two complexes by promoting the invasion of all novel antigens, including those that exhibit associations with the t-complex. Incompatibility can modify the relative numbers of antigens associated with each haplotype by actively promoting the exclusion or invasion of recombinants that bear formerly +-specific or t-specific antigens on the alternative haplotype. The results of the analysis indicate that the state of complete independence between the MHC and the t-complex is not preserved over evolutionary time in the presence of incompatibility. Further, the expression of incompatibility maintains fully associated states that include a single antigen associated with the t-haplotype and up to three to five antigens associated with the +-haplotype within a single population.

scholarly journals A quantitative model for a nanoscale switch accurately predicts thermal actuation behavior

Nanoscale ◽  
2021 ◽  
Author(s):  
Kyle Crocker ◽  
Joshua Johnson ◽  
Wolfgang Pfeifer ◽  
Carlos Ernesto Castro ◽  
Ralf Bundschuh
Keyword(s):  
Gold Nanoparticles ◽  
Partition Function ◽  
Physical Model ◽  
Function Analysis ◽  
Quantitative Model ◽  
Dna Origami ◽  
Thermal Actuation

Manipulation of temperature can be used to actuate DNA origami nano-hinges containing gold nanoparticles. We develop a physical model of this system that uses partition function analysis of the interaction...

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