Motor planning for what matters: Pursuing a quantitative model of effort

2009 ◽  
Author(s):  
Chase J. Coelho ◽  
David A. Rosenbaum
Keyword(s):  
Motor Planning ◽  
Quantitative Model ◽  
What Matters

Quantitative Model-Based Image Analysis of NuMa Distribution Links Nuclear Organization with Cell Phenotype

2001 ◽  
Vol 7 (S2) ◽  
pp. 578-579
Author(s):  
David W. Knowles ◽  
Sophie A. Lelièvre ◽  
Carlos Ortiz de Solόrzano ◽  
Stephen J. Lockett ◽  
Mina J. Bissell ◽  
...  
Keyword(s):  
Image Analysis ◽  
Mammary Epithelial Cells ◽  
Nuclear Organization ◽  
Critical Role ◽  
Quantitative Model ◽  
Mammary Epithelial ◽  
Cell Phenotype ◽  
Proliferating Cells ◽  
Mitotic Apparatus ◽  
Model Based

The extracellular matrix (ECM) plays a critical role in directing cell behaviour and morphogenesis by regulating gene expression and nuclear organization. Using non-malignant (S1) human mammary epithelial cells (HMECs), it was previously shown that ECM-induced morphogenesis is accompanied by the redistribution of nuclear mitotic apparatus (NuMA) protein from a diffuse pattern in proliferating cells, to a multi-focal pattern as HMECs growth arrested and completed morphogenesis . A process taking 10 to 14 days.To further investigate the link between NuMA distribution and the growth stage of HMECs, we have investigated the distribution of NuMA in non-malignant S1 cells and their malignant, T4, counter-part using a novel model-based image analysis technique. This technique, based on a multi-scale Gaussian blur analysis (Figure 1), quantifies the size of punctate features in an image. Cells were cultured in the presence and absence of a reconstituted basement membrane (rBM) and imaged in 3D using confocal microscopy, for fluorescently labeled monoclonal antibodies to NuMA (fαNuMA) and fluorescently labeled total DNA.

A Phonomotor Approach to Apraxia of Speech Treatment

2020 ◽  
Vol 29 (4) ◽  
pp. 2109-2130
Author(s):  
Lauren Bislick
Keyword(s):  
Phase I ◽  
Treatment Effects ◽  
Single Case ◽  
Motor Planning ◽  
The Other ◽  
Multimodal Approach ◽  
Apraxia Of Speech ◽  
Duration Of Treatment ◽  
Treatment Gains ◽  
Future Work

Purpose This study continued Phase I investigation of a modified Phonomotor Treatment (PMT) Program on motor planning in two individuals with apraxia of speech (AOS) and aphasia and, with support from prior work, refined Phase I methodology for treatment intensity and duration, a measure of communicative participation, and the use of effect size benchmarks specific to AOS. Method A single-case experimental design with multiple baselines across behaviors and participants was used to examine acquisition, generalization, and maintenance of treatment effects 8–10 weeks posttreatment. Treatment was distributed 3 days a week, and duration of treatment was specific to each participant (criterion based). Experimental stimuli consisted of target sounds or clusters embedded nonwords and real words, specific to each participants' deficit. Results Findings show improved repetition accuracy for targets in trained nonwords, generalization to targets in untrained nonwords and real words, and maintenance of treatment effects at 10 weeks posttreatment for one participant and more variable outcomes for the other participant. Conclusions Results indicate that a modified version of PMT can promote generalization and maintenance of treatment gains for trained speech targets via a multimodal approach emphasizing repeated exposure and practice. While these results are promising, the frequent co-occurrence of AOS and aphasia warrants a treatment that addresses both motor planning and linguistic deficits. Thus, the application of traditional PMT with participant-specific modifications for AOS embedded into the treatment program may be a more effective approach. Future work will continue to examine and maximize improvements in motor planning, while also treating anomia in aphasia.

What Matters To You Is What Makes You

ASHA Leader ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 42-46
Author(s):  
Bridget Murray Law
Keyword(s):  
What Matters

What Matters Most

2001 ◽  
Vol 2 (1) ◽  
pp. 21-21
Author(s):  
Mary Ann Lyon Knittel
Keyword(s):  
What Matters

Welcome to the Blog on What Matters Most

2011 ◽  
Vol 44 (5) ◽  
pp. 7
Author(s):  
WILLIAM E. GOLDEN
Keyword(s):  
What Matters

The Influences of Goal and Laterality of a Prepared Hand Response on a Co-Occurring Visual Search

2015 ◽  
Vol 74 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Alexandre Coutté ◽  
Gérard Olivier ◽  
Sylvane Faure
Keyword(s):  
Visual Search ◽  
Visual Target ◽  
Motor Planning ◽  
Search Performance ◽  
Response Preparation ◽  
Manual Response ◽  
Response Hand ◽  
Computer Screen ◽  
Left Hand ◽  
Manual Interaction

Computer use generally requires manual interaction with human-computer interfaces. In this experiment, we studied the influence of manual response preparation on co-occurring shifts of attention to information on a computer screen. The participants were to carry out a visual search task on a computer screen while simultaneously preparing to reach for either a proximal or distal switch on a horizontal device, with either their right or left hand. The response properties were not predictive of the target’s spatial position. The results mainly showed that the preparation of a manual response influenced visual search: (1) The visual target whose location was congruent with the goal of the prepared response was found faster; (2) the visual target whose location was congruent with the laterality of the response hand was found faster; (3) these effects have a cumulative influence on visual search performance; (4) the magnitude of the influence of the response goal on visual search is marginally negatively correlated with the rapidity of response execution. These results are discussed in the general framework of structural coupling between perception and motor planning.

The Impact of Visual Feedback Type on the Mastery of Visuo-Motor Transformations

2012 ◽  
Vol 220 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Sandra Sülzenbrück
Keyword(s):  
Empirical Research ◽  
Visual Feedback ◽  
Closed Loop ◽  
Motor Planning ◽  
Visual Input ◽  
Closed Loop Control ◽  
Loop Control ◽  
Feedback Type ◽  
Effective Use ◽  
The Impact

For the effective use of modern tools, the inherent visuo-motor transformation needs to be mastered. The successful adjustment to and learning of these transformations crucially depends on practice conditions, particularly on the type of visual feedback during practice. Here, a review about empirical research exploring the influence of continuous and terminal visual feedback during practice on the mastery of visuo-motor transformations is provided. Two studies investigating the impact of the type of visual feedback on either direction-dependent visuo-motor gains or the complex visuo-motor transformation of a virtual two-sided lever are presented in more detail. The findings of these studies indicate that the continuous availability of visual feedback supports performance when closed-loop control is possible, but impairs performance when visual input is no longer available. Different approaches to explain these performance differences due to the type of visual feedback during practice are considered. For example, these differences could reflect a process of re-optimization of motor planning in a novel environment or represent effects of the specificity of practice. Furthermore, differences in the allocation of attention during movements with terminal and continuous visual feedback could account for the observed differences.

Cooperative selection of action in tapping: A quantitative model

1991 ◽  
Author(s):  
Jonathan Vaughan ◽  
David A. Rosenbaum ◽  
Cathleen Moore
Keyword(s):  
Quantitative Model ◽  
Selection Of
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