Inhibitory Effect of Digested-Cartilage Acellular Matrix on Corneal Neovascularization in a Rabbit Model

2020 ◽  
Author(s):  
Hee-Woong Yun ◽  
Byung Hyune Choi ◽  
Do Young Park ◽  
Byoung-Hyun Min
Keyword(s):  
Rabbit Model ◽  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Acellular Matrix

The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model

2007 ◽  
Vol 7 (6) ◽  
pp. 631-636 ◽  
Author(s):  
Julio Urrutia ◽  
Rodrigo Mardones ◽  
Felipe Quezada
Keyword(s):  
Spinal Fusion ◽  
Rabbit Model ◽  
Fusion Rate ◽  
Autologous Bone Graft ◽  
Inhibitory Effect ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs ◽  
Single Level ◽  
Solid Fusion ◽  
Lumbar Spinal

Object Several reports have shown that nonsteroidal antiinflammatory drugs (NSAIDs) have an inhibitory effect in osteogenesis and reduce heterotopic ossification in humans. A deleterious effect of NSAIDs in posterolateral intertransverse process fusion has also been suggested. The authors used a validated rabbit model to try to determine the influence of the NSAID ketoprophen on the fusion rate in lumbar spinal arthrodesis. Methods Thirty New Zealand male rabbits underwent posterolateral (intertransverse process) bilateral spinal fusions at a single level, using autologous bone graft obtained from both iliac crests. The animals were randomized after the operation, so that 15 rabbits received ketoprophen as a postoperative analgesic and the other 15 received the postoperative analgesic tramadol. The animals were killed 8 weeks after surgery, and fusion status was determined by inspection, palpation, anteroposterior radiographs, and histological analysis. Results A solid fusion was obtained in eight rabbits (53%), and pseudarthrosis in seven rabbits (47%) in each group. Conclusions These findings suggest that the use of ketoprophen after intertransverse spinal fusion at a single level does not decrease the fusion rate, compared with tramadol.

Inhibitory Effect of Curcumin on Corneal Neovascularization in vitro and in vivo

2008 ◽  
Vol 222 (3) ◽  
pp. 178-186 ◽  
Author(s):  
Fang Bian ◽  
Ming-Chang Zhang ◽  
Yun Zhu
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect

Inhibitory Effect of Canstatin in Alkali Burn-Induced Corneal Neovascularization

2011 ◽  
Vol 46 (2) ◽  
pp. 66-72 ◽  
Author(s):  
Ye Wang ◽  
Hongmei Yin ◽  
Peng Chen ◽  
Lixin Xie ◽  
Yiqiang Wang
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Alkali Burn

Reconstruction of Penile Urethra With the 3-Dimensional Porous Bladder Acellular Matrix in a Rabbit Model

Urology ◽  
2014 ◽  
Vol 84 (6) ◽  
pp. 1499-1505 ◽  
Author(s):  
Jian-Wen Huang ◽  
Min-Kai Xie ◽  
Yuanyuan Zhang ◽  
Gai-Jie Wei ◽  
Xiang Li ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Acellular Matrix ◽  
3 Dimensional

scholarly journals Effects of VEGF Inhibitor Conbercept on Corneal Neovascularization Following Penetrating Keratoplasty in Rabbit Model

2020 ◽  
Vol Volume 14 ◽  
pp. 2185-2193
Author(s):  
Huan Liu ◽  
Xiao-Rong Zhang ◽  
Hong-Chang Xu ◽  
Yue Ma ◽  
Li-Ying Huang ◽  
...  
Keyword(s):  
Penetrating Keratoplasty ◽  
Rabbit Model ◽  
Corneal Neovascularization ◽  
Vegf Inhibitor

scholarly journals Inhibitory Effect of Topical Cartilage Acellular Matrix Suspension Treatment on Neovascularization in a Rabbit Corneal Model

2020 ◽  
Vol 17 (5) ◽  
pp. 625-640
Author(s):  
Hee-Woong Yun ◽  
Byung Hyune Choi ◽  
Do Young Park ◽  
Long Hao Jin ◽  
Byoung-Hyun Min
Keyword(s):  
Inhibitory Effect ◽  
Acellular Matrix

scholarly journals RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization

2019 ◽  
Vol 116 (47) ◽  
pp. 23705-23713 ◽  
Author(s):  
Takashi Ueta ◽  
Kenji Ishihara ◽  
Shoji Notomi ◽  
Jong-Jer Lee ◽  
Daniel E. Maidana ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Inflammatory Cells ◽  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Interleukin 4 ◽  
Caspase Activation ◽  
Interacting Protein ◽  
Pathological Angiogenesis ◽  
Caspase Inhibition

Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remains elusive. Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using kinase-inactive RIP1K45A/K45A mice or necrostatin-1 attenuates angiogenesis in laser-induced choroidal neovascularization, Matrigel plug angiogenesis, and alkali injury-induced corneal neovascularization in mice. The inhibitory effect on angiogenesis is mediated by caspase activation through a kinase-independent function of RIP1 and RIP3. Mechanistically, infiltrating macrophages are the key target of RIP1 kinase inhibition to attenuate pathological angiogenesis. Inhibition of RIP1 kinase activity is associated with caspase activation in infiltrating macrophages and decreased expression of proangiogenic M2-like markers but not M1-like markers. Similarly, in vitro, catalytic inhibition of RIP1 down-regulates the expression of M2-like markers in interleukin-4–activated bone marrow-derived macrophages, and this effect is blocked by simultaneous caspase inhibition. Collectively, these results demonstrate a nonnecrotic function of RIP1 kinase activity and suggest that RIP1-mediated modulation of macrophage activation may be a therapeutic target of pathological angiogenesis.

Inhibitory Effect of Tumstatin on Corneal Neovascularization Both In-vitro and In-vivo

2011 ◽  
Vol 02 (02) ◽  
Author(s):  
Venugopal Gunda ◽  
Shoujian Wang ◽  
Nader Sheibani ◽  
Akulapalli Sudhakar
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect
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