Inhibitory Effect of Canstatin in Alkali Burn-Induced Corneal Neovascularization

2011 ◽  
Vol 46 (2) ◽  
pp. 66-72 ◽  
Author(s):  
Ye Wang ◽  
Hongmei Yin ◽  
Peng Chen ◽  
Lixin Xie ◽  
Yiqiang Wang
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Alkali Burn

Inhibitory Effect of Sub-conjunctival Tocilizumab on Alkali Burn Induced Corneal Neovascularization in Rats

2014 ◽  
Vol 40 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Esin Sogutlu Sari ◽  
Alper Yazıcı ◽  
Hasan Aksit ◽  
Arzu Yay ◽  
Gözde Sahin ◽  
...  
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Alkali Burn

scholarly journals Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization

2018 ◽  
Vol 59 (5) ◽  
pp. 2133 ◽  
Author(s):  
Mingjun Tang ◽  
Ying Yang ◽  
Jingzhi Yu ◽  
Jin Qiu ◽  
Pei Chen ◽  
...  
Keyword(s):  
Corneal Neovascularization ◽  
Cxcr4 Signaling ◽  
Alkali Burn

Inhibitory Effect of Curcumin on Corneal Neovascularization in vitro and in vivo

2008 ◽  
Vol 222 (3) ◽  
pp. 178-186 ◽  
Author(s):  
Fang Bian ◽  
Ming-Chang Zhang ◽  
Yun Zhu
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect

Inhibitory Effect of Oral Doxycycline on Neovascularization in a Rat Corneal Alkali Burn Model of Angiogenesis

2008 ◽  
Vol 33 (8) ◽  
pp. 653-660 ◽  
Author(s):  
Liang Dan ◽  
Yan Shi-long ◽  
Lin Miao-li ◽  
Li Yong-ping ◽  
Ma Hong-jie ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Alkali Burn ◽  
Oral Doxycycline

scholarly journals RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization

2019 ◽  
Vol 116 (47) ◽  
pp. 23705-23713 ◽  
Author(s):  
Takashi Ueta ◽  
Kenji Ishihara ◽  
Shoji Notomi ◽  
Jong-Jer Lee ◽  
Daniel E. Maidana ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Inflammatory Cells ◽  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Interleukin 4 ◽  
Caspase Activation ◽  
Interacting Protein ◽  
Pathological Angiogenesis ◽  
Caspase Inhibition

Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remains elusive. Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using kinase-inactive RIP1K45A/K45A mice or necrostatin-1 attenuates angiogenesis in laser-induced choroidal neovascularization, Matrigel plug angiogenesis, and alkali injury-induced corneal neovascularization in mice. The inhibitory effect on angiogenesis is mediated by caspase activation through a kinase-independent function of RIP1 and RIP3. Mechanistically, infiltrating macrophages are the key target of RIP1 kinase inhibition to attenuate pathological angiogenesis. Inhibition of RIP1 kinase activity is associated with caspase activation in infiltrating macrophages and decreased expression of proangiogenic M2-like markers but not M1-like markers. Similarly, in vitro, catalytic inhibition of RIP1 down-regulates the expression of M2-like markers in interleukin-4–activated bone marrow-derived macrophages, and this effect is blocked by simultaneous caspase inhibition. Collectively, these results demonstrate a nonnecrotic function of RIP1 kinase activity and suggest that RIP1-mediated modulation of macrophage activation may be a therapeutic target of pathological angiogenesis.

Inhibitory Effect of Tumstatin on Corneal Neovascularization Both In-vitro and In-vivo

2011 ◽  
Vol 02 (02) ◽  
Author(s):  
Venugopal Gunda ◽  
Shoujian Wang ◽  
Nader Sheibani ◽  
Akulapalli Sudhakar
Keyword(s):  
Corneal Neovascularization ◽  
Inhibitory Effect

MSCs inhibits the angiogenesis of HUVECs through the miR-211/Prox1 pathway

2019 ◽  
Vol 166 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Jian Pan ◽  
Xianglong Wang ◽  
Dequan Li ◽  
Jianmin Li ◽  
Zipei Jiang
Keyword(s):  
Umbilical Vein ◽  
Critical Role ◽  
Corneal Opacity ◽  
Corneal Neovascularization ◽  
Inhibitory Effect ◽  
Tube Formation ◽  
Prox1 Expression ◽  
Umbilical Vein Endothelial Cells

Abstract The aim of this study was to investigate the effect of mesenchymal stem cells (MSCs) on the angiogenesis of human umbilical vein endothelial cells (HUVECs). MSCs were subconjunctival injected into rat corneal alkali burn models. Their impacts on the degree of corneal neovascularization (CNV) and corneal opacity were evaluated at 3, 6, 9 and 12 days after injection. An in vitro experiment of MSCs affecting HUVECs angiogenesis was performed and evaluated using the tube formation assay. The results showed that both CNV and corneal opacity were decreased in rats after MSCs injection. In HUVECs, angiogenesis of cells was inhibited by miR-211 overexpression. miR-211 negatively regulated Prox1 expression. Knockdown of miR-211 blocked the decrease of Prox1 expression induced by MSCs and the inhibitory effect of MSCs on the angiogenesis of HUVECs. The critical role of miR-211 in MSCs inhibition of corneal angiogenesis was confirmed in rat experiments. We concluded that MSCs inhibited the angiogenesis of HUVEC through miR-211 mediating the down-regulation of Prox1.

Suppression of Alkali Burn-Induced Corneal Neovascularization by Dendritic Cell Vaccination Targeting VEGF Receptor 2

2008 ◽  
Vol 49 (5) ◽  
pp. 2172 ◽  
Author(s):  
Hiroshi Mochimaru ◽  
Tomohiko Usui ◽  
Tomonori Yaguchi ◽  
Yasuharu Nagahama ◽  
Go Hasegawa ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Corneal Neovascularization ◽  
Dendritic Cell Vaccination ◽  
Vegf Receptor ◽  
Alkali Burn
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