scholarly journals Effects of VEGF Inhibitor Conbercept on Corneal Neovascularization Following Penetrating Keratoplasty in Rabbit Model

2020 ◽  
Vol Volume 14 ◽  
pp. 2185-2193
Author(s):  
Huan Liu ◽  
Xiao-Rong Zhang ◽  
Hong-Chang Xu ◽  
Yue Ma ◽  
Li-Ying Huang ◽  
...  
Keyword(s):  
Penetrating Keratoplasty ◽  
Rabbit Model ◽  
Corneal Neovascularization ◽  
Vegf Inhibitor

scholarly journals Corneal Neovascularization and Lipid Keratopathy after Intacs SK in Keratoconus

2013 ◽  
Vol 2 (3) ◽  
pp. 133-138
Author(s):  
Ramez Barbara ◽  
David Zadok ◽  
Adel Barbara ◽  
Shay Gutfreund
Keyword(s):  
Visual Acuity ◽  
Penetrating Keratoplasty ◽  
Corneal Neovascularization ◽  
Young Female ◽  
Spherical Equivalent ◽  
Corrected Visual Acuity ◽  
Optical Zone ◽  
Positive Results ◽  
Oval Shape ◽  
Best Corrected Visual Acuity

ABSTRACT Intacs have yielded positive results for the treatment of keratoconus in terms of reducing the keratometry readings astigmatism and spherical equivalent and consequently improving the uncorrected and best corrected visual acuity. Intacs severe keratoconus (SK) are new design of Intacs with a smaller optical zone (6 mm) and oval shape, they are indicated for severe keratocnus. Pannus is one of the complications of Intacs, as it has never been reported after Intacs SK. We report on corneal neovascularization in the corneal periphery which developed few months after Intacs SK implantation in the cornea of a young female who suffered from advanced keratoconus. The uncorrected visual (UCVA) acuity was satisfactory and the Intacs SK where not removed. Four years after the implantation she presented to our clinic complaining about eye irritation and photophobia, lipid keratopathy was observed. We gave here the choice of explanting the Intacs SK or to try to treat the neovascularization by subconjunctival Avastin, she preferred the second option because of a satisfactory UCVA (0.9). Avastin was injected in the subconjunctival, 10 weeks later Avastin and Kenelog were injected in the subconjunctival, few days after the second injection perforation and melting developed in the cornea, the patient underwent a tectonic graft and few months later penetrating keratoplasty with no intraoperative or postoperative complications. How to cite this article Barbara A, Zadok D, Gutfreund S, Barbara R. Corneal Neovascularization and Lipid Keratopathy after Intacs SK in Keratoconus. J Kerat Ect Cor Dis 2013;2(3):133-138.

Immunosuppression by a subconjunctival implant releasing dexamethasone in a rabbit model of penetrating keratoplasty

2018 ◽  
Vol 102 (5) ◽  
pp. 692-699
Author(s):  
Emmanuel Crouzet ◽  
Thibaud Garcin ◽  
Anne-Sophie Gauthier ◽  
Zhiguo He ◽  
Chantal Perrache ◽  
...  
Keyword(s):  
Penetrating Keratoplasty ◽  
Corneal Thickness ◽  
Rabbit Model ◽  
Rejection Rate ◽  
Ultra Performance Liquid Chromatography ◽  
Dexamethasone Implant ◽  
Ocular Tissues ◽  
Liquid Chromatography Tandem Mass ◽  
High Rejection Rate ◽  
Local Side

AimsTo evaluate the efficacy of a subconjunctival dexamethasone-releasing implant in preventing rejection of penetrating keratoplasty (PK) in an animal model.MethodsTwenty-two rabbits underwent allogenic PK. After randomisation, they received either a 700 µg dexamethasone implant under the conjunctiva at the end of surgery (n=10), one dexamethasone 1 mg/mL eye-drop thrice daily (n=6) or a placebo thrice daily (n=6). The suture was left in place. Animals were observed weekly by slit-lamp and optical coherence tomography with quantification of transparency, neovascularisation and central corneal thickness (CCT). At 5–6 weeks, they were euthanised for histology. The residual dexamethasone concentration in ocular tissues was measured with an ultra-performance liquid chromatography-tandem mass spectrometer.ResultsPlacebo group: early neovascularisation was systematic, penetrating the graft by 270–360° at 5–6 weeks. Rejection occurred in 50% of cases. Eye-drop and implant groups: similar course without rejection at 6 weeks and normal CCT. Neovascularisation was observed in 5/6 rabbits in the eye-drop group and in 6/8 in the implant group, with two cases of new vessels penetrating the graft from week 3. Neovascularisation scores did not differ significantly between the two treatments and were significantly lower than for the placebo. Histology was in agreement in all cases. Implants disappeared after 3–5 weeks. No local side effect was observed. Tissue concentrations were all higher at day 8 (n=2) in the implant group than in the eye drop group and lower at 6 weeks (n=8).ConclusionsIn this PK model characterised by a high rejection rate, a subconjunctival dexamethasone implant was for 6 weeks as effective as the topical form in preventing allograft rejection.

Immunosuppression with a subconjunctival implant releasing dexamethasone in a rabbit model of penetrating keratoplasty

2016 ◽  
Vol 94 ◽  
Author(s):  
E. Crouzet ◽  
Z. He ◽  
C. Perrache ◽  
T. Basset ◽  
X. Delavenne ◽  
...  
Keyword(s):  
Penetrating Keratoplasty ◽  
Rabbit Model

scholarly journals Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model

2019 ◽  
Vol 62 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Maya Eiger-Moscovich ◽  
Eitan Livny ◽  
Ruti Sella ◽  
Orly Gal-Or ◽  
Yael Nisgav ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Corneal Neovascularization

Inhibition of Corneal Neovascularization by Subconjunctival and Topical Bevacizumab and Sunitinib in a Rabbit Model

Cornea ◽  
2013 ◽  
Vol 32 (5) ◽  
pp. 689-695 ◽  
Author(s):  
Byung-Yi Ko ◽  
Young-sung Kim ◽  
Sung-gook Baek ◽  
Gun-woong Lee ◽  
Jae-Min Kim ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Corneal Neovascularization

scholarly journals Epidemiology of Corneal Neovascularization and Its Impact on Visual Acuity and Sensitivity: A 14-Year Retrospective Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Romina Mayra Lasagni Vitar ◽  
Giacinto Triolo ◽  
Philippe Fonteyne ◽  
Cecilia Acuti Martellucci ◽  
Lamberto Manzoli ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Penetrating Keratoplasty ◽  
Herpes Simplex Virus Infection ◽  
Corneal Neovascularization ◽  
Corneal Sensitivity ◽  
Corneal Dystrophies ◽  
Corrected Visual Acuity ◽  
Herpes Keratitis ◽  
Simplex Virus

Purpose: To quantify the severity and location of corneal neovascularization (cNV) and its impact on the visual acuity and corneal sensitivity in a cohort of the patients referred to a specialist cornea clinic and also to describe the etiology of cNV in the cohort.Methods: We retrospectively evaluated the charts of 13,493 subjects referred to the San Raffaele Cornea Unit between January 2004 and December 2018 to search for cNV diagnosis. The corneal neovascularization severity was measured in the quadrants (range: 1–4) and location was defined as superficial, deep, or both. Best spectacle corrected visual acuity (BSCVA) was measured in logMar. We used the multiple regression analysis to identify the independent predictors of logMAR, after adjusting for age, gender, keratoconus, herpes keratitis, penetrating keratoplasty, trauma, and cataract surgery.Results: Corneal neovascularization was diagnosed in 10.4% of the patients analyzed. The most prevalent etiology of cNV in our population was non-infectious corneal dystrophies/degenerations followed by herpes simplex virus infection. cNV affected OD, OS, or both eyes in 35.6, 40.2, and 24.2 of cases, respectively. Mean BSCVA (SD) was 0.59 (0.76), 0.74 (0.94), and 1.24 (1.08) in cNV one, two, and three or four of the quadrant groups. Superficial, deep, or mixed cNV occurred in 1,029, 348, and 205 eyes. Severe cNV (three or four of the quadrants) was a significant predictor of low visual acuity (p < 0.001) and reduced corneal sensitivity (p < 0.05). cNV location and its severity were associated (p < 0.05). In addition, corneal anesthesia was associated with lower BSCVA (p < 0.001).Conclusion: Severe and deep cNV are associated with the reduced visual acuity and corneal sensitivity. Our data strongly support the relevance of appropriate follow-up as cNV is a major risk factor for graft rejection.

Topical Bevacizumab for Corneal Neovascularization after Penetrating Keratoplasty

2009 ◽  
Vol 19 (5) ◽  
pp. 870-872 ◽  
Author(s):  
Sandeep Saxena ◽  
Poonam Kishore ◽  
Sukant Pandey ◽  
Mohit Khattri ◽  
Dipak Kumar
Keyword(s):  
Penetrating Keratoplasty ◽  
Corneal Neovascularization
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