Molecular Modelling Based Design and Synthesis of Donepezil Like Derivatives As Acetylcholinesterase Inhibitors

2020 ◽  
Author(s):  
Nitish Kumar ◽  
Preet Mohinder Singh Bedi
Keyword(s):  
Molecular Modelling ◽  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis

scholarly journals Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 955 ◽  
Author(s):  
Sri Sukumaran ◽  
Chin Chee ◽  
Geetha Viswanathan ◽  
Michael Buckle ◽  
Rozana Othman ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation

scholarly journals Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors

2017 ◽  
Vol 27 (2) ◽  
pp. 228-231 ◽  
Author(s):  
Alireza Basiri ◽  
Michelle Xiao ◽  
Alec McCarthy ◽  
Debashis Dutta ◽  
Siddappa N. Byrareddy ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis

Drugs Against Neurodegenerative Diseases: Design and Synthesis of 6-Amino-substituted Imidazo[1,2-b]pyridazines as Acetylcholinesterase Inhibitors

2017 ◽  
Vol 2 (2) ◽  
pp. 842-847 ◽  
Author(s):  
P. Sridhar ◽  
Manikandan Alagumuthu ◽  
B. Ram ◽  
Sivakumar Arumugam ◽  
Sabbasani Rajasekhara Reddy
Keyword(s):  
Neurodegenerative Diseases ◽  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis

Synthesis, preclinical evaluation and molecular modelling of macrocyclic appended 1-(2-methoxyphenyl)piperazine for 5-HT1A neuroreceptor imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7288-7301 ◽  
Author(s):  
Puja Panwar Hazari ◽  
Surbhi Prakash ◽  
Virendra Kumar Meena ◽  
Niraj Singh ◽  
Krishna Chuttani ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Chelating Agent ◽  
Agent Based ◽  
Preclinical Evaluation ◽  
Efficient Approach ◽  
Design And Synthesis ◽  
Neuroreceptor Imaging

An efficient approach in the design and synthesis of a multi-functional chelating agent based on 1-(2-methoxyphenyl)piperazine for targeting 5-HT1A receptors in brain was envisaged.

Design and synthesis of thienopyridines as novel templates for acetylcholinesterase inhibitors

2012 ◽  
Vol 22 (9) ◽  
pp. 4087-4095 ◽  
Author(s):  
Mohga M. Badran ◽  
Maha Abdel Hakeem ◽  
Suzan M. Abuel-Maaty ◽  
Afaf El-Malah ◽  
Rania M. Abdel Salam
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis

Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors

2016 ◽  
Vol 69 ◽  
pp. 91-101 ◽  
Author(s):  
Sufyan Ahmad ◽  
Fatima Iftikhar ◽  
Farhat Ullah ◽  
Abdul Sadiq ◽  
Umer Rashid
Keyword(s):  
Binding Site ◽  
Rational Design ◽  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis

Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents

2019 ◽  
Vol 19 (19) ◽  
pp. 1577-1598 ◽  
Author(s):  
Yaghoub Pourshojaei ◽  
Khalil Eskandari ◽  
Ali Asadipour
Keyword(s):  
Cognitive Abilities ◽  
Memory Loss ◽  
Acetylcholinesterase Inhibitors ◽  
Crystallographic Structure ◽  
Design And Synthesis ◽  
Cortex Area ◽  
Wide Range ◽  
Common Term ◽  
The Brain

: Alzheimer, a progressive disease, is a common term for memory loss which interferes with daily life through severe influence on cognitive abilities. Based on the cholinergic hypothesis, and Xray crystallographic determination of the structure of acetylcholinesterase (AChE) enzyme, the level of acetylcholine (ACh, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on Alzheimer. This fact encourages scientists to design and synthesize a wide range of acetylcholinesterase inhibitors (AChEIs) to control the level of ACh in the brain, keeping in view the crystallographic structure of AChE enzyme and drugs approved by the Food and Drug Administration (FDA). : AChEIs have slightly diverse pharmacological properties, but all of them work by inhibiting the segregation of ACh by blocking AChE. We reviewed significant scaffolds introduced as AChEIs. In some studies, the activity against butyrylcholinesterase (BuChE) has been evaluated as well because BuChE is a similar enzyme to neuronal acetylcholinesterase and is capable of hydrolyzing ACh. In order to study AChEIs effectively, we divided them structurally into 12 classes and briefly explained effective AChEIs and compared their activities against AChE enzyme.

Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors

2020 ◽  
pp. 1-11
Author(s):  
Zafer Sahin ◽  
Sevde Nur Biltekin ◽  
Emre Fatih Bülbül ◽  
Leyla Yurttas ◽  
Barkin Berk ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Design And Synthesis
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