Synthesis, preclinical evaluation and molecular modelling of macrocyclic appended 1-(2-methoxyphenyl)piperazine for 5-HT1A neuroreceptor imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7288-7301 ◽  
Author(s):  
Puja Panwar Hazari ◽  
Surbhi Prakash ◽  
Virendra Kumar Meena ◽  
Niraj Singh ◽  
Krishna Chuttani ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Chelating Agent ◽  
Agent Based ◽  
Preclinical Evaluation ◽  
Efficient Approach ◽  
Design And Synthesis ◽  
Neuroreceptor Imaging

An efficient approach in the design and synthesis of a multi-functional chelating agent based on 1-(2-methoxyphenyl)piperazine for targeting 5-HT1A receptors in brain was envisaged.

ChemInform Abstract: Synthesis of a Novel Hexadentate Chelating Agent Based on 8-Hydroxyquinoline.

ChemInform ◽  
1988 ◽  
Vol 19 (32) ◽  
Author(s):  
W. D. SHRADER ◽  
J. CELEBUSKI ◽  
S. J. KLINE ◽  
D. JOHNSON
Keyword(s):  
Chelating Agent ◽  
Agent Based

Stimulation of High-Temperature Sandstone Formations From West Africa With Chelating Agent-Based Fluids

2008 ◽  
Vol 23 (01) ◽  
pp. 32-38 ◽  
Author(s):  
Syed A. Ali ◽  
Emee Ermel ◽  
John Clarke ◽  
Michael J. Fuller ◽  
Zhijun Xiao ◽  
...  
Keyword(s):  
High Temperature ◽  
West Africa ◽  
Chelating Agent ◽  
Agent Based ◽  
Stimulation Of

Stimulation of High-Temperature Sandstone Formations from West Africa with Chelating Agent-Based Fluids

2005 ◽  
Author(s):  
Syed Afaq Ali ◽  
Emee Ermel ◽  
John Clarke ◽  
Michael James Fuller ◽  
Zhijun Xiao ◽  
...  
Keyword(s):  
High Temperature ◽  
West Africa ◽  
Chelating Agent ◽  
Agent Based ◽  
Stimulation Of

Picolinic acid based acyclic bifunctional chelating agent and its methionine conjugate as potential SPECT imaging agents: syntheses and preclinical evaluation

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 33963-33973 ◽  
Author(s):  
K. Ganesh Kadiyala ◽  
Tulika Tyagi ◽  
Dipti Kakkar ◽  
Nidhi Chadha ◽  
Krishna Chuttani ◽  
...  
Keyword(s):  
Picolinic Acid ◽  
Chelating Agent ◽  
Spect Imaging ◽  
Imaging Agents ◽  
Preclinical Evaluation ◽  
Bifunctional Chelating Agent

Syntheses and preclinical evaluation of picolinic acid based acyclic bifunctional chelating agent and its methionine conjugate as SPECT imaging agents.

scholarly journals Synthetic Amphoteric Cryogels as an Antidote against Acute Heavy Metal Poisoning

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7601
Author(s):  
Alzhan Z. Baimenov ◽  
Ildar R. Fakhradiyev ◽  
Dmitriy A. Berillo ◽  
Timur Saliev ◽  
Sergey V. Mikhalovsky ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Morphological Structure ◽  
Chelating Agent ◽  
Acute Poisoning ◽  
Control Group ◽  
High Survival ◽  
Agent Based ◽  
In Vivo Experiments ◽  
Acid Sodium Salt

The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD50 dose of Cd(NO3)2, CsNO3, Sr(NO3)2, or HgCl2 in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals.

The Efficacy of a Chelating Agent-Based Oxide Remover to Clean Corrosion Products from Ferrous Fracture Surfaces

2019 ◽  
Vol 19 (6) ◽  
pp. 1860-1865
Author(s):  
Aphrodite Strifas ◽  
Michael K. Budinski ◽  
Edward Komarnicki ◽  
Nancy B. McAtee ◽  
Matthew Fox ◽  
...  
Keyword(s):  
Chelating Agent ◽  
Corrosion Products ◽  
Agent Based ◽  
Fracture Surfaces

scholarly journals Development of Chelating Agent-Based Polymeric Gel System for Hydraulic Fracturing

Energies ◽  
2018 ◽  
Vol 11 (7) ◽  
pp. 1663 ◽  
Author(s):  
Muhammad Kamal ◽  
Marwan Mohammed ◽  
Mohamed Mahmoud ◽  
Salaheldin Elkatatny
Keyword(s):  
Hydraulic Fracturing ◽  
Sea Water ◽  
Chelating Agent ◽  
Gelling Agent ◽  
Fracturing Fluid ◽  
Fluid System ◽  
Agent Based ◽  
Breaking Time ◽  
Glutamic Acid Diacetic Acid ◽  
High Shearing

Hydraulic Fracturing is considered to be one of the most important stimulation methods. Hydraulic Fracturing is carried out by inducing fractures in the formation to create conductive pathways for the flow of hydrocarbon. The pathways are kept open either by using proppant or by etching the fracture surface using acids. A typical fracturing fluid usually consists of a gelling agent (polymers), cross-linkers, buffers, clay stabilizers, gel stabilizers, biocide, surfactants, and breakers mixed with fresh water. The numerous additives are used to prevent damage resulting from such operations, or better yet, enhancing it beyond just the aim of a fracturing operation. This study introduces a new smart fracturing fluid system that can be either used for proppant fracturing (high pH) or acid fracturing (low pH) operations in sandstone formations. The fluid system consists of glutamic acid diacetic acid (GLDA) that can replace several additives, such as cross-linker, breaker, biocide, and clay stabilizer. GLDA is also a surface-active fluid that will reduce the interfacial tension eliminating the water-blockage effect. GLDA is compatible and stable with sea water, which is advantageous over the typical fracturing fluid. It is also stable in high temperature reservoirs (up to 300 °F) and it is also environmentally friendly and readily biodegradable. The new fracturing fluid formulation can withstand up to 300 °F of formation temperature and is stable for about 6 h under high shearing rates (511 s−1). The new fracturing fluid formulation breaks on its own and the delay time or the breaking time can be controlled with the concentrations of the constituents of the fluid (GLDA or polymer). Coreflooding experiments were conducted using Scioto and Berea sandstone cores to evaluate the effectiveness of the developed fluid. The flooding experiments were in reasonable conformance with the rheological properties of the developed fluid regarding the thickening and breaking time, as well as yielding high return permeability.

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