scholarly journals Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 955 ◽  
Author(s):  
Sri Sukumaran ◽  
Chin Chee ◽  
Geetha Viswanathan ◽  
Michael Buckle ◽  
Rozana Othman ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation

Thiazole-Based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling

2020 ◽  
Vol 21 ◽  
Author(s):  
Michelyn Haroun ◽  
Christopher Tratrat ◽  
Evangelia Tsolaki ◽  
Anthi Petrou ◽  
Antonis Gavalas ◽  
...  
Keyword(s):  
Aromatic Aldehyde ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Chalcone Derivatives ◽  
Treat Ment ◽  
Anti Inflammatory

Background.: Inflammation is a multifactorial process reflecting response of the organismto various stimuli and is associated to a number of disorders such as arthritis, asthma and psoriasis, which require long-lasting or repeated treat-ment. Objective.: The aim of this paper is to evaluate the anti-inflammatory activity of previous synthesized thiazole-based chal-cone derivatives. Method.: Chalcones were synthesized via Cliazen-Schmidt condensation1-(4-methyl-2-alkylamino)thiazol-5-yl) ethanone with corresponding aromatic aldehyde. For the evaluation of possible anti-inflammatory activity carrageneen mouse paw edema was used. Results.: Eight out of thirteen tested chalcones showed anti-inflammatory activity in range of 51-55%. Prediction of toxicity revealed that these compounds are not toxic. Conclusion.: In general, it can be concluded that these compounds can be used for further modifications in order to develop more active and safe agents.

Synthesis and biological evaluation of novel C1-glycosyl thiazole derivatives as acetylcholinesterase inhibitors

2016 ◽  
Vol 40 (9) ◽  
pp. 545-548 ◽  
Author(s):  
Long Yin ◽  
Feng–Chang Cheng ◽  
Qu–Xiang Li ◽  
Wei–Wei Liu ◽  
Xiu–Jian Liu ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Thiazole Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of benzothiazin-4-ones: a possible new class of acetylcholinesterase inhibitors

2018 ◽  
Vol 34 (1) ◽  
pp. 196-202 ◽  
Author(s):  
Gabriele A. Berwaldt ◽  
Daniela P. Gouvêa ◽  
Daniel S. da Silva ◽  
Adriana M. das Neves ◽  
Mayara S. P. Soares ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
New Class ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as novel acetylcholinesterase inhibitors

ARKIVOC ◽  
2009 ◽  
Vol 2009 (10) ◽  
pp. 333-348 ◽  
Author(s):  
Si-jie Liu ◽  
a Liu Yang ◽  
Zhe Jin ◽  
Er-fang Huang ◽  
David Chi Cheong Wan ◽  
...  
Keyword(s):  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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