scholarly journals A Framework for Separating Individual Treatment Effects from Spillover, Interaction, and General Equilibrium Effects

2017 ◽  
Author(s):  
Martin Huber ◽  
Andreas Steinmayr
Keyword(s):  
General Equilibrium ◽  
Treatment Effects ◽  
Individual Treatment

scholarly journals General Equilibrium Treatment Effects: A Study of Tuition Policy

10.3386/w6426 ◽  
1998 ◽  
Author(s):  
James Heckman ◽  
Lance Lochner ◽  
Christopher Taber
Keyword(s):  
General Equilibrium ◽  
Treatment Effects ◽  
Tuition Policy

An evaluation of estimating and indexing methods to simplify the determination of management treatment effects on raspberry yields

2003 ◽  
Vol 83 (1) ◽  
pp. 141-147 ◽  
Author(s):  
C. G. Kowalenko
Keyword(s):  
Treatment Effects ◽  
Correlation Coefficients ◽  
Crop Management ◽  
Rubus Idaeus ◽  
Individual Treatment ◽  
Index Method ◽  
Significant Treatment ◽  
Nutrient Effects ◽  
Biomass N ◽  
Index Methods

The effectiveness of using several proposals to estimate or index yield and size of raspberries as an alternative to picking berries as they ripen was examined in two field plot trials over two seasons at two locations in south coast British Columbia. The evaluation included examination of general correlations of the proposed estimate and index values with fresh picked yield, comparison of the significant nutrient and inter-row management treatment effects on proposed method values with effects on fresh picked yield values, influence of individual cane variability to distinguish significant treatment effects, and the effect of N on plant components used to derive the estimate and index method. Correlation coefficients for all yield estimate and index method values with fresh picked yields were generally good. Crop management treatment effects determined by the estimate and index values, however, were not the same as determined by harvesting the berries as they ripened. This showed that the estimate and index method values were biased relative to picked yield. Cane-to-cane variability within individual treatment plots was sufficiently large that differences between treatments had to be greater than 10 to 15% to be significant at P < 0.05 when five canes were randomly sampled for index component measurements to represent the plants in the plot. The five canes sampled for each plot were 5 to 10% of all the floricanes in the plots of this study. The concentration and biomass N measurements that were possible on the floricane components that were sampled for the index methods showed that management treatments of the two trials of the study could have influenced berry development, and hence contributed to the bias of the estimate and index method values relative to fresh picked yield. Although the estimate and index methods were generally quite well correlated with fresh picked yield, caution is advised when they are used directly as alternatives to fresh picking to evaluate crop management treatment effects on berry yield. Further knowledge about the physiological changes that occur during berry ripening may provide opportunities to improve the estimate and index measurements. Key words: Raspberry, Rubus idaeus L., yield estimate, yield index, nutrient effects, nitrogen effects

scholarly journals Individual Treatment Effects of Budget Balance Rules

2020 ◽  
Vol 20 (274) ◽  
Author(s):  
Francesca Caselli ◽  
Daniel Stoehlker ◽  
Philippe Wingender
Keyword(s):  
Treatment Effects ◽  
National Level ◽  
Specific Treatment ◽  
Average Treatment Effect ◽  
Fiscal Rules ◽  
Individual Treatment ◽  
Significant Heterogeneity ◽  
Budget Balance ◽  
The Government ◽  
Country Specific

This paper investigates the heterogenous effects of budget balance rules on fiscal policy in a large sample of countries. To derive country-specific treatment effects of fiscal rules and conduct inference, we use a Synthetic Difference-in-Differences Method. Our results indicate that countries with a budget balance rule improve their fiscal balance on average by around 3 percent after its introduction. However, our results also illustrate the importance of going beyond the average treatment effect, as it masks significant heterogeneity in the country-specific impact of the rule. We find that countries that would have had large deficits in the absence of the fiscal rule exhibit positive treatment effects, thus reducing their budget deficits. On the other hand, countries with budget surpluses respond to fiscal rules by reducing their budget surplus and moving closer to the numerical target of the rule. Our results also suggest that rules’ design matters: a small overall number of fiscal rules, and the presence of a monitoring process outside the government, especially at the supra-national level, improve significantly the effectiveness of the rules.

scholarly journals A permutation test for assessing the presence of individual differences in treatment effects

2021 ◽  
pp. 096228022110336
Author(s):  
Chi Chang ◽  
Thomas Jaki ◽  
Muhammad Saad Sadiq ◽  
Alena Kuhlemeier ◽  
Daniel Feaster ◽  
...  
Keyword(s):  
Random Forests ◽  
Error Control ◽  
Treatment Effects ◽  
Type I Error ◽  
Permutation Test ◽  
Individual Treatment ◽  
Significant Heterogeneity ◽  
Type I ◽  
Data Set ◽  
Show Evidence

An important goal of personalized medicine is to identify heterogeneity in treatment effects and then use that heterogeneity to target the intervention to those most likely to benefit. Heterogeneity is assessed using the predicted individual treatment effects framework, and a permutation test is proposed to establish if significant heterogeneity is present given the covariates and predictive model or algorithm used for predicted individual treatment effects. We first show evidence for heterogeneity in the effects of treatment across an illustrative example data set. We then use simulations with two different predictive methods (linear regression model and Random Forests) to show that the permutation test has adequate type-I error control. Next, we use an example dataset as the basis for simulations to demonstrate the ability of the permutation test to find heterogeneity in treatment effects for a predicted individual treatment effects estimate as a function of both effect size and sample size. We find that the proposed test has good power for detecting heterogeneity in treatment effects when the heterogeneity was due primarily to a single predictor, or when it was spread across the predictors. Power was found to be greater for predictions from a linear model than from random forests. This non-parametric permutation test can be used to test for significant differences across individuals in predicted individual treatment effects obtained with a given set of covariates using any predictive method with no additional assumptions.

scholarly journals Individualized treatment effects with censored data via fully nonparametric Bayesian accelerated failure time models

Biostatistics ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 50-68 ◽  
Author(s):  
Nicholas C Henderson ◽  
Thomas A Louis ◽  
Gary L Rosner ◽  
Ravi Varadhan
Keyword(s):  
Treatment Effect ◽  
Treatment Effects ◽  
Failure Time ◽  
Enzyme Inhibitor ◽  
Model Specification ◽  
Accelerated Failure Time Model ◽  
Tuning Parameter ◽  
Individual Treatment ◽  
Accelerated Failure Time ◽  
Accelerated Failure

Summary Individuals often respond differently to identical treatments, and characterizing such variability in treatment response is an important aim in the practice of personalized medicine. In this article, we describe a nonparametric accelerated failure time model that can be used to analyze heterogeneous treatment effects (HTE) when patient outcomes are time-to-event. By utilizing Bayesian additive regression trees and a mean-constrained Dirichlet process mixture model, our approach offers a flexible model for the regression function while placing few restrictions on the baseline hazard. Our nonparametric method leads to natural estimates of individual treatment effect and has the flexibility to address many major goals of HTE assessment. Moreover, our method requires little user input in terms of model specification for treatment covariate interactions or for tuning parameter selection. Our procedure shows strong predictive performance while also exhibiting good frequentist properties in terms of parameter coverage and mitigation of spurious findings of HTE. We illustrate the merits of our proposed approach with a detailed analysis of two large clinical trials (N = 6769) for the prevention and treatment of congestive heart failure using an angiotensin-converting enzyme inhibitor. The analysis revealed considerable evidence for the presence of HTE in both trials as demonstrated by substantial estimated variation in treatment effect and by high proportions of patients exhibiting strong evidence of having treatment effects which differ from the overall treatment effect.

scholarly journals Higher treatment effect after total knee arthroplasty is associated with higher patient satisfaction

2020 ◽  
Author(s):  
Jörg Lützner ◽  
Franziska Beyer ◽  
Klaus-Peter Günther ◽  
Jörg Huber
Keyword(s):  
Total Knee Arthroplasty ◽  
Patient Satisfaction ◽  
Knee Arthroplasty ◽  
Treatment Effect ◽  
Treatment Effects ◽  
Oxford Knee Score ◽  
Individual Treatment ◽  
Total Knee ◽  
The Mean ◽  
One Year

Abstract Purpose The aim of this study was to investigate what influence the treatment effect after total knee arthroplasty (TKA) had on patient satisfaction. Methods Prospective registry data of a University-based arthroplasty centre were used. 582 patients with unilateral bicondylar TKA were analyzed. Treatment effect (TE) was deduced from Oxford Knee Score (OKS) before and one year after surgery. Positive values correspond to improved symptoms (maximum 1.0 reflect no symptoms at all) and negative values correspond to deterioration of symptoms. Satisfaction on a visual-analogue scale from 0 to 10 and the willingness to undergo TKA surgery again was assessed one year after surgery. Results The mean OKS improved from 22.1 before to 36.7 one year after TKA. Treatment effects ranged from 1.0 to –0.62 with a mean TE of 0.56. Taking an individual treatment effect of 0.2 as a cut-off between responder and non-responder, a total of 85.8% would be classified as responder after TKA. The mean satisfaction score with the TKA was 8.1. There was a significant correlation between the individual treatment effect and satisfaction after TKA (p < 0.001). The majority of patients (84.5%) would undergo surgery again. Patients not willing to undergo surgery again or those uncertain about this had lower satisfaction scores, a lower treatment effect and were more often female compared to patients who would undergo surgery again. Conclusion Higher individual treatment effects resulted in higher patient satisfaction and willingness to undergo surgery again. However, some patients with a relatively low treatment effect were highly satisfied, which indicates the need for both information. Level of evidence II.

scholarly journals Estimating individual treatment effects by gradient boosting trees

2019 ◽  
Vol 38 (26) ◽  
pp. 5146-5159 ◽  
Author(s):  
Shonosuke Sugasawa ◽  
Hisashi Noma
Keyword(s):  
Treatment Effects ◽  
Gradient Boosting ◽  
Individual Treatment
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