scholarly journals Pharmacokinetic Studies of Betotastine Besilate (TAU-284). (I): Absorption, Distribution, Metabolism and Excretion after a Single Oral Administration.

1997 ◽  
Vol 12 (5) ◽  
pp. 417-438
Author(s):  
Rikiya OHASHI ◽  
Mikiko TSUKIMOTO ◽  
Susumu NAKAMURA ◽  
Minezo OHTSUKA ◽  
Kazushi HAYASHI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Studies ◽  
Single Oral Administration

scholarly journals Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1816 ◽  
Author(s):  
You Jin Han ◽  
Bitna Kang ◽  
Eun-Ju Yang ◽  
Min-Koo Choi ◽  
Im-Sook Song
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Plasma Concentrations ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Elution Time ◽  
Glycyrrhizae Radix ◽  
Single Oral Administration ◽  
Limit Of Quantitation ◽  
Liquid Chromatography Tandem Mass

Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin, the four marker components of Glycyrrhizae Radix extract (GRE), in rat plasma using liquid chromatography-tandem mass spectrometry and to apply this analytical method to pharmacokinetic studies. Retention times for glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were 7.8 min, 4.1 min, 3.1 min, and 2.0 min, respectively, suggesting that the four analytes were well separated without any interfering peaks around the peak elution time. The lower limit of quantitation was 2 ng/mL for glycyrrhizin and 0.2 ng/mL for isoliquiritigenin, liquiritigenin, and liquiritin; the inter- and intra-day accuracy, precision, and stability were less than 15%. Plasma concentrations of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were quantified for 24 h after a single oral administration of 1 g/kg GRE to four rats. Among the four components, plasma concentration of glycyrrhizin was the highest and exhibited a long half-life (23.1 ± 15.5 h). Interestingly, plasma concentrations of isoliquiritigenin and liquiritigenin were restored to the initial concentration at 4–10 h after the GRE administration, as evidenced by liquiritin biotransformation into isoliquiritigenin and liquiritigenin, catalyzed by fecal lysate and gut wall enzymes. In conclusion, our analytical method developed for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.

scholarly journals Pharmacokinetic Studies of [14C]Urea. (3); Feto-placental Transfer and Excretion into Milk after Single Oral Administration of [14C] Urea in Rats.

2001 ◽  
Vol 16 (6) ◽  
pp. 521-527
Author(s):  
Naruaki NOMURA ◽  
Satoshi MATSUMOTO ◽  
Yuka NISHIMURA ◽  
Yoshiaki TERAUCHI ◽  
Toshihiko FUJII ◽  
...  
Keyword(s):  
Oral Administration ◽  
Placental Transfer ◽  
Pharmacokinetic Studies ◽  
Single Oral Administration

scholarly journals Pharmacokinetic studies of propiverine hydrochloride (2). Metabolism in rats after single oral administration of P-4.

1989 ◽  
Vol 4 (5) ◽  
pp. 553-561 ◽  
Author(s):  
Yoshio YAMAMOTO ◽  
Yoshinori MINAMI ◽  
Masahiko YOSHIDA ◽  
Masuhiro TSUDA ◽  
Kazuhiko UDA ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Studies ◽  
Single Oral Administration

Josamycin concentrations in radicular cysts following a single oral administration

1993 ◽  
Vol 24 (1) ◽  
pp. 143-145 ◽  
Author(s):  
Yoshiaki Akimoto ◽  
Yoshiko Mochizuki ◽  
Akio Uda ◽  
Hiroaki Omata ◽  
Sumio Saito ◽  
...  
Keyword(s):  
Oral Administration ◽  
Single Oral Administration

Pharmacokinetics and tolerance of the hypolipidaemic RP 54275 following single oral administration to male volunteers

1990 ◽  
Vol 183 (5) ◽  
pp. 1846-1847
Author(s):  
C.D. Evans ◽  
G.D. Jones ◽  
V. Facchini ◽  
J. McEwen ◽  
Y. Yeang
Keyword(s):  
Oral Administration ◽  
Male Volunteers ◽  
Single Oral Administration
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