scholarly journals Pharmacokinetic studies of trimoprostil in rats. (I). Blood level profile, tissue distribution and excretion after a single oral administration of trimoprostil.

1986 ◽  
Vol 1 (1) ◽  
pp. 43-53
Author(s):  
Hiroki TOMISAWA ◽  
Noriko ICHIMOTO ◽  
Shigeyasu ICHIHARA ◽  
Hideo FUKAZAWA ◽  
Mitsuru TATEISHI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Tissue Distribution ◽  
Blood Level ◽  
Pharmacokinetic Studies ◽  
Single Oral Administration ◽  
Level Profile

scholarly journals Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1816 ◽  
Author(s):  
You Jin Han ◽  
Bitna Kang ◽  
Eun-Ju Yang ◽  
Min-Koo Choi ◽  
Im-Sook Song
Keyword(s):  
Oral Administration ◽  
Analytical Method ◽  
Plasma Concentrations ◽  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Elution Time ◽  
Glycyrrhizae Radix ◽  
Single Oral Administration ◽  
Limit Of Quantitation ◽  
Liquid Chromatography Tandem Mass

Glycyrrhizae Radix is widely used as herbal medicine and is effective against inflammation, various cancers, and digestive disorders. We aimed to develop a sensitive and simultaneous analytical method for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin, the four marker components of Glycyrrhizae Radix extract (GRE), in rat plasma using liquid chromatography-tandem mass spectrometry and to apply this analytical method to pharmacokinetic studies. Retention times for glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were 7.8 min, 4.1 min, 3.1 min, and 2.0 min, respectively, suggesting that the four analytes were well separated without any interfering peaks around the peak elution time. The lower limit of quantitation was 2 ng/mL for glycyrrhizin and 0.2 ng/mL for isoliquiritigenin, liquiritigenin, and liquiritin; the inter- and intra-day accuracy, precision, and stability were less than 15%. Plasma concentrations of glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin were quantified for 24 h after a single oral administration of 1 g/kg GRE to four rats. Among the four components, plasma concentration of glycyrrhizin was the highest and exhibited a long half-life (23.1 ± 15.5 h). Interestingly, plasma concentrations of isoliquiritigenin and liquiritigenin were restored to the initial concentration at 4–10 h after the GRE administration, as evidenced by liquiritin biotransformation into isoliquiritigenin and liquiritigenin, catalyzed by fecal lysate and gut wall enzymes. In conclusion, our analytical method developed for detecting glycyrrhizin, isoliquiritigenin, liquiritigenin, and liquiritin could be successfully applied to investigate their pharmacokinetic properties in rats and would be useful for conducting further studies on the efficacy, toxicity, and biopharmaceutics of GREs and their marker components.

scholarly journals Studies on the Pharmacokinetics of Perindopril Erbumine in Rats. (2): Blood Level Profile, Distribution, Metabolism and Excretion after Repeated Oral Administration.

1994 ◽  
Vol 9 (2) ◽  
pp. 247-257
Author(s):  
Minoru NAKAOKA ◽  
Hideo HAKUSUI ◽  
Yoshitaka JIN ◽  
Syuichirou TUTUMI ◽  
Akiko HIRONAKA ◽  
...  
Keyword(s):  
Oral Administration ◽  
Blood Level ◽  
Perindopril Erbumine ◽  
Profile Distribution ◽  
Level Profile

Blood Level Profile in Man following Chronic Oral Administration of Flurazepam Hydrochloride

1973 ◽  
Vol 62 (12) ◽  
pp. 1932-1935 ◽  
Author(s):  
S.A. Kaplan ◽  
J.A.F. de Silva ◽  
M.L. Jack ◽  
K. Alexander ◽  
N. Strojny ◽  
...  
Keyword(s):  
Oral Administration ◽  
Blood Level ◽  
Level Profile

scholarly journals Pharmacokinetic Studies of [14C]Urea. (3); Feto-placental Transfer and Excretion into Milk after Single Oral Administration of [14C] Urea in Rats.

2001 ◽  
Vol 16 (6) ◽  
pp. 521-527
Author(s):  
Naruaki NOMURA ◽  
Satoshi MATSUMOTO ◽  
Yuka NISHIMURA ◽  
Yoshiaki TERAUCHI ◽  
Toshihiko FUJII ◽  
...  
Keyword(s):  
Oral Administration ◽  
Placental Transfer ◽  
Pharmacokinetic Studies ◽  
Single Oral Administration
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