scholarly journals Farnesoid X receptor and liver X receptors regulate Oct3/4 expression by multiple feedback regulating system in normal renal-derived cells and renal adenocarcinoma cells

2020 ◽  
Vol 45 (1) ◽  
pp. 25-35
Author(s):  
Tomofumi Fujino ◽  
Kouta Sugizaki ◽  
Rei Kato ◽  
Masaki Beppu ◽  
Satoshi Murakami ◽  
...  
Keyword(s):  
Farnesoid X Receptor ◽  
Liver X Receptors ◽  
Renal Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
X Receptors

scholarly journals Natural Products Targeting Liver X Receptors or Farnesoid X Receptor

2022 ◽  
Vol 12 ◽  
Author(s):  
Jianglian She ◽  
Tanwei Gu ◽  
Xiaoyan Pang ◽  
Yonghong Liu ◽  
Lan Tang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Natural Products ◽  
Nuclear Receptors ◽  
Farnesoid X Receptor ◽  
Liver X Receptors ◽  
Terrestrial Plants ◽  
Comprehensive Overview ◽  
Chemical Structures ◽  
Bioactive Properties ◽  
X Receptors

Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals. Among NRs, the liver X receptors (LXRs) and farnesoid X receptor (FXR) have been of significance as targets for the treatment of metabolic syndrome-related diseases. In recent years, natural products targeting LXRs and FXR have received remarkable interests as a valuable source of novel ligands encompassing diverse chemical structures and bioactive properties. This review aims to survey natural products, originating from terrestrial plants and microorganisms, marine organisms, and marine-derived microorganisms, which could influence LXRs and FXR. In the recent two decades (2000–2020), 261 natural products were discovered from natural resources such as LXRs/FXR modulators, 109 agonists and 38 antagonists targeting LXRs, and 72 agonists and 55 antagonists targeting FXR. The docking evaluation of desired natural products targeted LXRs/FXR is finally discussed. This comprehensive overview will provide a reference for future study of novel LXRs and FXR agonists and antagonists to target human diseases, and attract an increasing number of professional scholars majoring in pharmacy and biology with more in-depth discussion.

scholarly journals LXRs, SHP, and FXR in Prostate Cancer: Enemies or Ménage à Quatre With AR?

2018 ◽  
Vol 15 ◽  
pp. 155076291880107 ◽  
Author(s):  
Marica Cariello ◽  
Simon Ducheix ◽  
Salwan Maqdasy ◽  
Silvère Baron ◽  
Antonio Moschetta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nuclear Receptors ◽  
Cancer Progression ◽  
Prostate Cancer Cell ◽  
Farnesoid X Receptor ◽  
New Drugs ◽  
Liver X Receptors ◽  
Castration Resistance ◽  
Orphan Nuclear Receptors ◽  
X Receptors

Androgens and androgen receptor (AR, NR3C4) clearly play a crucial role in prostate cancer progression. Besides, the link between metabolic disorders and the risk of developing a prostate cancer has been emerging these last years. Interestingly, “lipid” nuclear receptors such as LXRα/NR1H3 and LXRβ/NR1H2 (as well as FXRα/NR1H4 and SHP/NR0B2) have been described to decrease the lipid metabolism, while AR increases it. Moreover, these former orphan nuclear receptors can regulate androgen levels and modulate AR activity. Thus, it is not surprising to find such receptors involved in the physiology of prostate. This review is focused on the roles of liver X receptors (LXRs), farnesoid X receptor (FXR), and small heterodimeric partner (SHP) in prostate physiology and their capabilities to interfere with the androgen-regulated pathways by modulating the levels of active androgen within the prostate. By the use of prostate cancer cell lines, mice deficient for these nuclear receptors and human tissue libraries, several authors have pointed out the putative possibility to pharmacologically target these receptors. These data open a new field of research for the development of new drugs that could overcome the castration resistance in prostate cancer, a usual phenomenon in patients.

scholarly journals Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line

2017 ◽  
Vol 42 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Tomofumi Fujino ◽  
Ryosuke Sakamaki ◽  
Haruka Ito ◽  
Yumiko Furusato ◽  
Nami Sakamoto ◽  
...  
Keyword(s):  
Cell Line ◽  
Renal Cell ◽  
Farnesoid X Receptor ◽  
Renal Adenocarcinoma ◽  
Adenocarcinoma Cells

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus

2021 ◽  
pp. 104927
Author(s):  
Zhi Liang ◽  
Tanwei Gu ◽  
Jianjiao Wang ◽  
Jianglian She ◽  
Yuxiu Ye ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
Chromone Derivatives ◽  
X Receptors ◽  
Pestalotiopsis Neglecta

scholarly journals Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer

2021 ◽  
Author(s):  
Wanting Shao ◽  
Christina Kuhn ◽  
Doris Mayr ◽  
Nina Ditsch ◽  
Magdalena Kailuwait ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Poor Prognosis ◽  
Early Stage ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Parameters ◽  
Liver X Receptors ◽  
X Receptors ◽  
Independent Marker ◽  
Overall Survival Analysis

Abstract Purpose The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. Methods In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. Results LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II–III tumors Conclusion Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.

scholarly journals Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

2013 ◽  
Vol 18 (1) ◽  
pp. 106-117 ◽  
Author(s):  
Simon W. Beaven ◽  
Aleksey Matveyenko ◽  
Kevin Wroblewski ◽  
Lily Chao ◽  
Damien Wilpitz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver X Receptors ◽  
Reciprocal Regulation ◽  
X Receptors

scholarly journals Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 615-626 ◽  
Author(s):  
Fiona O'Mahony ◽  
Kevin Wroblewski ◽  
Sheila M. O'Byrne ◽  
Hongfeng Jiang ◽  
Kara Clerkin ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Liver X Receptors ◽  
X Receptors ◽  
Lipid Stores ◽  
Lipid Droplet Protein
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