Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for Liver X receptors Oxysterols modulate glycolysis in human macrophages

2020 ◽  
Author(s):  
Louise Ménégaut ◽  
Antoine Jalil ◽  
Thomas Pilot ◽  
Kevin Dongen ◽  
Valentin Crespy ◽  
...  
Keyword(s):  
Potential Role ◽  
Liver X Receptors ◽  
Human Macrophages ◽  
X Receptors

scholarly journals Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Ana Carolina Mota ◽  
Monica Dominguez ◽  
Andreas Weigert ◽  
Ryan G. Snodgrass ◽  
Dmitry Namgaladze ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Target Genes ◽  
Inflammatory Responses ◽  
Regulatory Element ◽  
Peroxisome Proliferator ◽  
Liver X Receptors ◽  
Human Macrophages ◽  
Sterol Regulatory Element ◽  
Peroxisome Proliferator Activated Receptors ◽  
X Receptors

Efferocytosis is critical for tissue homeostasis, as its deregulation is associated with several autoimmune pathologies. While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR) or liver X receptors (LXR) that orchestrate metabolic, phagocytic, and inflammatory responses towards the ingested material. Coordination of these transcription factors in efferocytotic human macrophages is not fully understood. In this study, we evaluated the transcriptional profile of macrophages following the uptake of apoptotic Jurkat T cells using RNA-seq analysis. Results indicated upregulation of PPAR and LXR pathways but downregulation of sterol regulatory element-binding proteins (SREBP) target genes. Pharmacological inhibition and RNA interference pointed to LXR and PPARδ as relevant transcriptional regulators, while PPARγ did not substantially contribute to gene regulation. Mechanistically, lysosomal digestion and lysosomal acid lipase (LIPA) were required for PPAR and LXR activation, while PPARδ activation also demanded an active lysosomal phospholipase A2 (PLA2G15). Pharmacological interference with LXR signaling attenuated ABCA1-dependent cholesterol efflux from efferocytotic macrophages, but suppression of inflammatory responses following efferocytosis occurred independently of LXR and PPARδ. These data provide mechanistic details on LXR and PPARδ activation in efferocytotic human macrophages.

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus

2021 ◽  
pp. 104927
Author(s):  
Zhi Liang ◽  
Tanwei Gu ◽  
Jianjiao Wang ◽  
Jianglian She ◽  
Yuxiu Ye ◽  
...  
Keyword(s):  
Liver X Receptors ◽  
Chromone Derivatives ◽  
X Receptors ◽  
Pestalotiopsis Neglecta

scholarly journals Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer

2021 ◽  
Author(s):  
Wanting Shao ◽  
Christina Kuhn ◽  
Doris Mayr ◽  
Nina Ditsch ◽  
Magdalena Kailuwait ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Poor Prognosis ◽  
Early Stage ◽  
Clinicopathological Characteristics ◽  
Clinicopathological Parameters ◽  
Liver X Receptors ◽  
X Receptors ◽  
Independent Marker ◽  
Overall Survival Analysis

Abstract Purpose The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patient survival. Methods In a well-characterized cohort of 305 primary BC, subcellular distribution of LXR was evaluated by immunohistochemistry. Correlations with clinicopathological characteristics as well as with patient outcome were analyzed. Results LXR was frequently localized in both nuclei and cytoplasms of BC cells, with stronger staining in nuclei. Total and nuclear LXR expression was positively correlated with ER and PR status. Overall survival analysis demonstrated that cytoplasmic LXR was significantly correlated with poor survival and appeared as an independent marker of poor prognosis, in stage I but not in stage II–III tumors Conclusion Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.

scholarly journals Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

2013 ◽  
Vol 18 (1) ◽  
pp. 106-117 ◽  
Author(s):  
Simon W. Beaven ◽  
Aleksey Matveyenko ◽  
Kevin Wroblewski ◽  
Lily Chao ◽  
Damien Wilpitz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver X Receptors ◽  
Reciprocal Regulation ◽  
X Receptors

scholarly journals Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

Hepatology ◽  
2015 ◽  
Vol 62 (2) ◽  
pp. 615-626 ◽  
Author(s):  
Fiona O'Mahony ◽  
Kevin Wroblewski ◽  
Sheila M. O'Byrne ◽  
Hongfeng Jiang ◽  
Kara Clerkin ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Liver X Receptors ◽  
X Receptors ◽  
Lipid Stores ◽  
Lipid Droplet Protein

scholarly journals Liver X Receptors Control IgE Expression in B Cells

2009 ◽  
Vol 182 (9) ◽  
pp. 5276-5282 ◽  
Author(s):  
Guido Heine ◽  
Anja Dahten ◽  
Kerstin Hilt ◽  
Dennis Ernst ◽  
Milena Milovanovic ◽  
...  
Keyword(s):  
B Cells ◽  
Liver X Receptors ◽  
X Receptors

Liver X receptors: new players in atherogenesis?

2003 ◽  
Vol 14 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Virginie Bocher ◽  
Lesley J. Millatt ◽  
Jean-Charles Fruchart ◽  
Bart Staels
Keyword(s):  
Liver X Receptors ◽  
X Receptors
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