Red Blood Cell Volume, Plasma Volume and Total Blood Volume in Healthy Elderly Men and Women Aged 64 to 100

1992 ◽  
Author(s):  
C. R. Valeri ◽  
Linda E. Pivacek ◽  
Hiliary Siebens ◽  
Mark D. Altschule
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Red Blood Cell ◽  
Total Blood Volume ◽  
Elderly Men ◽  
Total Blood ◽  
Men And Women ◽  
Healthy Elderly

scholarly journals Blood volume in monoclonal gammopathy

Blood ◽  
1977 ◽  
Vol 49 (2) ◽  
pp. 301-307 ◽  
Author(s):  
R Alexanian
Keyword(s):  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Monoclonal Gammopathy ◽  
Red Cell ◽  
Total Blood Volume ◽  
Elevated Plasma ◽  
Total Blood ◽  
Red Cell Volume ◽  
The Relationship

Abstract The plasma volume, red cell volume, or both were measured in 170 normal, anemic, or polycythemic subjects. For anemic subjects without a serum protein abnormality or splenomegaly, the relationship between hematocrit and red cell volume was linear and predictable. In patients with a serum monoclonal globulin on electrophoresis, the plasma voluem was significantly increased for the hematocrit in 30%, and the total blood volume was increased in 45%. The frequency of an elevated plasma volume was higher in patients with a markedly increased level of monoclonal protein. Reductions of abnormal proteins with chemotherapy were associated with declines in plasma volume. For a specific concentration, the serum viscosity was highest in patients with IgM proteins and lowest in patients with IgG globulins. Marked elevations in viscosity were noted only in sera with macroglobulinemia or with more than 5 g/dl of IgG or IgA globulins.

scholarly journals Plasma volume, cell volume, total blood volume and F factor in the tree shrew

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0234835
Author(s):  
Wei Xia ◽  
Zong-jian Huang ◽  
Zhao-liang Guo ◽  
Yi-wei Feng ◽  
Chao-yin Zhang ◽  
...  
Keyword(s):  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Tree Shrew ◽  
Total Blood Volume ◽  
Total Blood ◽  
F Factor ◽  
Volume Cell

scholarly journals Comparison of the Terumo BCT MNC and Cmnc Protocols for Peripheral Blood Stem Cell Collections

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5731-5731 ◽  
Author(s):  
Lindsey Westbrook ◽  
Joseph Roig ◽  
Neil Bagamasbad ◽  
Reynold Dilag ◽  
Melissa Nasser ◽  
...  
Keyword(s):  
Stem Cell ◽  
Blood Cell ◽  
Blood Volume ◽  
Mononuclear Cell ◽  
Red Blood Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Total Blood Volume ◽  
Total Blood ◽  
Run Time

Abstract Background: Terumo BCT recently offered a new method of peripheral blood stem cell (PBSC) collection using the Spectra Optia¨, an apheresis instrument. The new protocol includes a continuous mononuclear cell collection (CMNC) as opposed to an older version, the mononuclear cell collection (MNC), which involves an additional step where product pools through a cell separation insert. Our institution has used both methods and the purpose of this study was to compare the CMNC to the MNC protocol, including run times and PBSC product characteristics. Methods: A retrospective review and comparison of parameters from 120 collection procedures using the MNC insert and 60 collection procedures using the CMNC insert was done using the t-test. Data from patients/donors (including 20 allogeneic donors) as well as procedure details including run time, flow cytometry marker for stem cells (CD34)-positive (CD34+) throughput, CD34+ collection efficiency (CE%), platelet loss (plt loss/total blood volume [TBV]), and collection product characteristics were included in the analysis. Results: The MNC donor group included 12 allogeneic donors, which is comparable to the 8 allogeneic donors in the CMNC group. Donor weight and patient weight was not significantly different between the two groups. Pre-procedure laboratory values (WBC, percentage of lymphocytes [lymph%], percentage of monocytes [MNC%], and platelet count) were also similar between the two groups. Run time was found to be significantly shorter using the CMNC protocol compared to the MNC protocol. Product volume was also significantly lower in the CMNC group compared to the MNC group. Although the volume was lower, the CMNC product had significantly higher white blood cell count (WBC), MNC%, and lymph% when compared to the MNC product. The CD34+ throughput was significantly higher in the CMNC group than the MNC group. The CD34+ CE% was found to be slightly increased in the CMNC group, though not significantly. The platelet loss was nearly identical in both protocols when normalized for total blood volume. Product hematocrit (HCT%) was significantly higher using the CMNC protocol; however, the red blood cell volume never exceeded 20 mL due to the lower product volume with the CMNC protocol. The numerical results are summarized in the Table. Conclusion: The CMNC protocol collects a smaller volume of a purer product when compared to the MNC protocol with comparable platelet and red blood cell loss. Staff members who perform apheresis procedures are pleased by the shorter run time. Table Table. Disclosures Roig: Terumo BCT: Employment.

Cell volume, plasma volume, total blood volume and Fcells factor in the rhesus monkey

1958 ◽  
Vol 196 (1) ◽  
pp. 184-187 ◽  
Author(s):  
Magnus I. Gregersen ◽  
H. Sear ◽  
R. A. Rawson ◽  
Shu Chien ◽  
G. L. Saiger
Keyword(s):  
Rhesus Monkey ◽  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Total Blood Volume ◽  
Total Blood ◽  
Mean Values ◽  
Cell Percentage ◽  
Simultaneous Measurements ◽  
The Mean

Forty-two simultaneous measurements of plasma and cell volume with T-1824 and P32 were made on 18 normal monkeys ranging in weight from 3.4 to 7.1 kg. Nine determinations were made on two animals at varying intervals during a 16-month period. The mean values and standard deviations were as follows: cell volume 17.7 (S.D., 1.66) ml/kg; plasma volume, 36.4 (S.D., 3.98) ml/kg; blood volume, 54.0 (S.D., 4.72) ml/kg; Fcells factor, 0.83, (S.D., 0.046); venous cell percentage (hematocrit value x.96), 39.6; plasma protein (refractometer) 7.26 gm %. Variations among animals in plasma and blood volume, expressed in milliliters per kilogram were significantly greater than those observed in the same animal during the 16-month period.

Plasma volume, cell volume, total blood volume and Fcells factor in the normal and splenectomized Sherman rat

1958 ◽  
Vol 196 (1) ◽  
pp. 188-192 ◽  
Author(s):  
Louise Wang
Keyword(s):  
Body Weight ◽  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Simultaneous Measurement ◽  
Total Blood Volume ◽  
Total Blood ◽  
Unanesthetized Animals ◽  
Cell Volumes ◽  
Volume Cell

A method is described for the catheterization of the carotid of the rat which permits blood volume determinations to be made on unanesthetized animals. The cell volume (P32) and plasma volume (T-1824) were measured simultaneously on the day after catheterization. The average Fcells factor was 0.739 (S.D., 0.053) in 11 normal rats and 0.726 (S.D., 0.041) in 10 splenectomized rats. In 50 unanesthetized normal rats the plasma volume averaged 3.90 ml/100 gm body weight. The blood and cell volumes calculated by using the Fcells factor of 0.74 and the separately determined plasma trapping' factor of 0.95 averaged 5.93 ml/ 100 gm and 2.14 ml/100 gm, respectively. These values agree closely with those determined from the simultaneous measurement of cell and plasma volumes and also with the values obtained on 27 normal rats under ether.

Simultaneous determination of blood volume with Cr51 and T-1824 during hypothermia and rewarming

1959 ◽  
Vol 196 (4) ◽  
pp. 703-705 ◽  
Author(s):  
E. J. Fedor ◽  
B. Fisher
Keyword(s):  
Cell Volume ◽  
Simultaneous Determination ◽  
Blood Volume ◽  
Plasma Volume ◽  
Red Cell ◽  
Total Blood Volume ◽  
Total Blood ◽  
Red Cell Volume ◽  
Usual Feature

Dogs lightly anesthetized with ether, maintained between 23–24°C for 2 hours and rewarmed, were subjected to simultaneous determinations of red cell volume (Cr51) and plasma volume (T-1824). Red cell volume values were unchanged during the course of the experiment. Plasma volumes were significantly decreased during hypothermia and were transiently elevated during rewarming. Twenty-four hours after rewarming, total blood volume and plasma volume values were not significantly different from control values. It would seem that circulatory failure (‘rewarming shock’) is not a usual feature of rewarming following hypothermia of 2 hours duration.

Serum immunoreactive erythropoietin and red blood cell mass during pregnancy in conscious rats

1993 ◽  
Vol 265 (2) ◽  
pp. R399-R403 ◽  
Author(s):  
G. O. Del Valle ◽  
M. D. Mosher ◽  
K. P. Conrad
Keyword(s):  
Animal Model ◽  
Blood Cell ◽  
Plasma Volume ◽  
Red Blood Cell ◽  
Cell Mass ◽  
P Value ◽  
Total Blood Volume ◽  
Total Blood ◽  
Serum Erythropoietin ◽  
In Pregnancy

Serum erythropoietin concentration increases during human pregnancy and presumably accounts for expansion of red blood cell mass. The mechanism(s) underlying gestational changes of serum erythropoietin are unknown. Moreover, if erythropoietin synthesis increases, then the organ(s) questions about erythropoietin in pregnancy, we first set out to establish an animal model. Chronically instrumented, conscious unrestrained rats were studied. 51Cr-labeled red blood cells and radioimmunoassay were used to assess red blood cell mass and serum erythropoietin, respectively. Except for a lower hematocrit (P < 0.05 vs. virgin rats) and a slightly higher plasma volume (P value not significant) for gravid rats on gestational day 6, all other variables measured in early pregnancy rats were comparable to those measured in virgin control animals. Significant increases in total blood volume, plasma volume, and red blood cell mass were observed by gestational day 13 (midpregnancy) when compared with virgin control rats. These changes were even more pronounced on gestational day 20. Serum immunoreactive erythropoietin was also significantly increased at both of these stages of pregnancy. We conclude that the gravid rat is a reliable animal model of human gestation in which to further investigate erythropoietin in pregnancy.

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