Evaluation of Mouse Wound Models for Probiotics-Based Wound Infection Prevention Study

2016 ◽  
Author(s):  
Alex Lentsch ◽  
Rebecca Schuster
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Prevention Study

Enzymatically crosslinked epsilon-poly-l-lysine hydrogels with inherent antibacterial properties for wound infection prevention

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8620-8627 ◽  
Author(s):  
Rui Wang ◽  
De-lei Xu ◽  
Lei Liang ◽  
Ting-ting Xu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Enzymatic Catalysis ◽  
Antibacterial Properties

Anin situforming hydrogel derived from epsilon-poly-l-lysine was crosslinked by the enzymatic catalysis method and showed excellent antibacterial properties for wound infection prevention.

scholarly journals Burns wound infection: Prevention and treatment

2014 ◽  
Vol 43 (6) ◽  
pp. 36-43
Author(s):  
Rade Panajotović ◽  
Marko Panajotović ◽  
Ljubomir Panajotović
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Prevention And Treatment

Use of an intraoperative sodium oxychlorosene–based infection prevention protocol to safely decrease postoperative wound infections after spine surgery

2021 ◽  
pp. 1-7
Author(s):  
Vincent J. Alentado ◽  
Robert P. Berwanger ◽  
Anabel M. Konesco ◽  
Alex J. Potts ◽  
Caroline A. Potts ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Wound Infection ◽  
Spine Surgery ◽  
Postoperative Infection ◽  
Infection Prevention ◽  
Protocol Implementation ◽  
Postoperative Wound ◽  
Deep Wound ◽  
Prevention Protocol

OBJECTIVE Postoperative infection remains prevalent after spinal surgical procedures. Institutional protocols for infection prevention have improved rates of infection after spine surgery. However, prior studies have focused on only elective surgical patients. The aim of this study was to determine the efficacy of a multiinstitutional intraoperative sodium oxychlorosene–based infection prevention protocol for decreasing rate of infection after instrumented spinal surgery. METHODS A retrospective analysis was performed at two tertiary care institutions with level I trauma programs, and patients who underwent posterior instrumented spinal fusion between January 1, 2011, and May 31, 2019, were included. Postoperative deep wound infection rates were captured before and after implementation of a multiinstitutional infection prevention protocol. Possible adverse outcomes related to infection prevention techniques were also examined. In addition, consecutive patients treated from January 1, 2018, to May 31, 2019, were prospectively included in a database to collect preoperative and postoperative spine-specific quality of life measures and to assess the impact of postoperative infection on quality of life. RESULTS A total of 5047 patients fit the inclusion criteria. Of these, 1043 patients underwent surgery prior to protocol implementation. The infection rate of this cohort (3.5%) decreased significantly after protocol implementation (1.2%, p < 0.001). Postoperative sterile seroma rates did not differ between the preprotocol and postprotocol groups (0.7% vs 0.7%, p = 0.5). In the 1031 patients who underwent surgery between January 2018 and May 2019, the fusion rate was 89.2%. Quality of life outcomes between patients with infection and those without infection were similar, although statistical power was limited owing to the low rate of infection. Notably, 2 of 10 patients who developed deep wound infection died of infection-related complications. CONCLUSIONS An intraoperative sodium oxychlorosene–based infection prevention protocol helped to significantly decrease the rate of infection after spine surgery without negatively impacting other postoperative procedure-related metrics. Postoperative wound infection may be associated with higher-than-expected rate of postoperative mortality.

scholarly journals Measures for Preventing Wound Infections During Elective Open Surgery for Colorectal Cancer: Scrubbing With Gauze

2014 ◽  
Vol 99 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Takanori Goi ◽  
Yuki Ueda ◽  
Toshiyuki Nakazawa ◽  
Katsuji Sawai ◽  
Mitsuhiro Morikawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Surgical Site Infection ◽  
Wound Infection ◽  
Infection Prevention ◽  
Simple Procedure ◽  
Wound Infections ◽  
Site Infection ◽  
Prevention Measures ◽  
Group A ◽  
Group B

Abstract In addition to the general surgical-site infection prevention measures in colorectal cancer surgery, we performed a simple subcutaneous scrubbing procedure with gauze at the time of abdominal closure, which reduced the incidence of wound infections. There are 289 patients whose primary colon cancer lesions were removed by elective surgeries. They were divided into Group A (74 patients with no wound infection prevention measures who were treated from 2002 to 2003), Group B (76 patients with wound infection prevention measures who were treated from 2007 to 2008), and Group C (139 patients with subcutaneous scrubbing with gauze plus the measures in Group B who were treated from 2009 to 2012). The incidence in Group A was 23%, while the corresponding values in Group B and Group C were 14.5% and 2.9%, respectively. The incidence of wound infections was substantially reduced by additional subcutaneous scrubbing with a saline solution and gauze during closure of a surgical incision. This very simple procedure was considered useful for surgical site infection prevention.

scholarly journals Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention

2014 ◽  
Vol 2 (29) ◽  
pp. 4660 ◽  
Author(s):  
Gisela Solange Alvarez ◽  
Christophe Hélary ◽  
Andrea Mathilde Mebert ◽  
Xiaolin Wang ◽  
Thibaud Coradin ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Infection ◽  
Infection Prevention ◽  
Silica Nanoparticle ◽  
Composite Hydrogels
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