Wound infection prevention by topical antibiotics

1967 ◽  
Vol 54 (5) ◽  
pp. 324-329 ◽  
Author(s):  
Ernest A. Ryan
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Topical Antibiotics

Wound Infection and Topical Antibiotics

1977 ◽  
Vol 112 (10) ◽  
pp. 1240 ◽  
Author(s):  
Nicholas A. Halasz
Keyword(s):  
Wound Infection ◽  
Topical Antibiotics

Enzymatically crosslinked epsilon-poly-l-lysine hydrogels with inherent antibacterial properties for wound infection prevention

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8620-8627 ◽  
Author(s):  
Rui Wang ◽  
De-lei Xu ◽  
Lei Liang ◽  
Ting-ting Xu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Enzymatic Catalysis ◽  
Antibacterial Properties

Anin situforming hydrogel derived from epsilon-poly-l-lysine was crosslinked by the enzymatic catalysis method and showed excellent antibacterial properties for wound infection prevention.

scholarly journals Burns wound infection: Prevention and treatment

2014 ◽  
Vol 43 (6) ◽  
pp. 36-43
Author(s):  
Rade Panajotović ◽  
Marko Panajotović ◽  
Ljubomir Panajotović
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Prevention And Treatment

scholarly journals 127Topical antibiotics used to prevent infection in the ICU: an accidental natural herd exposure experiment

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
James Hurley
Keyword(s):  
Systematic Reviews ◽  
Infection Prevention ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Topical Antibiotic ◽  
Herd Effect ◽  
Icu Patients ◽  
Topical Antibiotics ◽  
Prevention Methods

Abstract Background Multiple studies of topical antibiotics applied to ICU patients appear to show potent infection prevention effects versus studies of other interventions. However, the effect is less apparent for studies using non-concurrent (NCC) versus concurrent controls (CC) implying the possibility of a herd effect. Methods 206 studies of infection prevention among ICU patients, sourced from 15 systematic reviews were stratified into those using topical antibiotics with NCC versus with CC versus studies of other prevention methods. The event rates were summarised using generalized estimating equations and compared to other studies without an intervention (literature benchmark). Results The summary effect sizes for pneumonia and mortality prevention derived in the systematic reviews were replicated. The mean ICU mortality incidence for topical antibiotic study CC control groups (28.5%; 95% CI, 25.0-32.3; n = 41) is higher versus a literature benchmark (23.7%; 19.2%-28.5%; n = 34), versus NCC control groups (23.5%; 19.3-28.3; n = 14) and versus topical antibiotic intervention groups (24.4%; 22.1 – 26.9; n = 62). In meta-regression models adjusted for group mean age and publication year, CC group membership within a topical antibiotic study remains associated with higher mortality (p = 0.027). Conclusions Within topical antibiotic studies, the CC control group mortality incidences are inexplicably high, whereas the intervention group incidences are paradoxically similar to a literature-derived benchmark. Key messages An adverse herd effect is apparent for topical antibiotics used to prevent infection among ICU patients.

scholarly journals The role of topical antibiotics used as prophylaxis in surgical site infection prevention

2011 ◽  
Vol 66 (4) ◽  
pp. 693-701 ◽  
Author(s):  
S. M. McHugh ◽  
C. J. Collins ◽  
M. A. Corrigan ◽  
A. D. K. Hill ◽  
H. Humphreys
Keyword(s):  
Surgical Site Infection ◽  
Infection Prevention ◽  
Site Infection ◽  
Topical Antibiotics

Use of an intraoperative sodium oxychlorosene–based infection prevention protocol to safely decrease postoperative wound infections after spine surgery

2021 ◽  
pp. 1-7
Author(s):  
Vincent J. Alentado ◽  
Robert P. Berwanger ◽  
Anabel M. Konesco ◽  
Alex J. Potts ◽  
Caroline A. Potts ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Wound Infection ◽  
Spine Surgery ◽  
Postoperative Infection ◽  
Infection Prevention ◽  
Protocol Implementation ◽  
Postoperative Wound ◽  
Deep Wound ◽  
Prevention Protocol

OBJECTIVE Postoperative infection remains prevalent after spinal surgical procedures. Institutional protocols for infection prevention have improved rates of infection after spine surgery. However, prior studies have focused on only elective surgical patients. The aim of this study was to determine the efficacy of a multiinstitutional intraoperative sodium oxychlorosene–based infection prevention protocol for decreasing rate of infection after instrumented spinal surgery. METHODS A retrospective analysis was performed at two tertiary care institutions with level I trauma programs, and patients who underwent posterior instrumented spinal fusion between January 1, 2011, and May 31, 2019, were included. Postoperative deep wound infection rates were captured before and after implementation of a multiinstitutional infection prevention protocol. Possible adverse outcomes related to infection prevention techniques were also examined. In addition, consecutive patients treated from January 1, 2018, to May 31, 2019, were prospectively included in a database to collect preoperative and postoperative spine-specific quality of life measures and to assess the impact of postoperative infection on quality of life. RESULTS A total of 5047 patients fit the inclusion criteria. Of these, 1043 patients underwent surgery prior to protocol implementation. The infection rate of this cohort (3.5%) decreased significantly after protocol implementation (1.2%, p < 0.001). Postoperative sterile seroma rates did not differ between the preprotocol and postprotocol groups (0.7% vs 0.7%, p = 0.5). In the 1031 patients who underwent surgery between January 2018 and May 2019, the fusion rate was 89.2%. Quality of life outcomes between patients with infection and those without infection were similar, although statistical power was limited owing to the low rate of infection. Notably, 2 of 10 patients who developed deep wound infection died of infection-related complications. CONCLUSIONS An intraoperative sodium oxychlorosene–based infection prevention protocol helped to significantly decrease the rate of infection after spine surgery without negatively impacting other postoperative procedure-related metrics. Postoperative wound infection may be associated with higher-than-expected rate of postoperative mortality.

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