scholarly journals Burns wound infection: Prevention and treatment

2014 ◽  
Vol 43 (6) ◽  
pp. 36-43
Author(s):  
Rade Panajotović ◽  
Marko Panajotović ◽  
Ljubomir Panajotović
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Prevention And Treatment

scholarly journals Antibiotic-Releasing Silk Biomaterials for Infection Prevention and Treatment

2012 ◽  
Vol 23 (7) ◽  
pp. 854-861 ◽  
Author(s):  
Eleanor M. Pritchard ◽  
Thomas Valentin ◽  
Bruce Panilaitis ◽  
Fiorenzo Omenetto ◽  
David L. Kaplan
Keyword(s):  
Infection Prevention ◽  
Prevention And Treatment

scholarly journals Characterization and Antibiofilm Activity of Mannitol–Chitosan-Blended Paste for Local Antibiotic Delivery System

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 517 ◽  
Author(s):  
Leslie R. Pace ◽  
Zoe L. Harrison ◽  
Madison N. Brown ◽  
Warren O. Haggard ◽  
J. Amber Jennings
Keyword(s):  
Infection Prevention ◽  
Bacterial Biofilm ◽  
Antibiofilm Activity ◽  
Persister Cells ◽  
In Vivo Evaluation ◽  
Musculoskeletal Infection ◽  
Prevention And Treatment ◽  
Local Antibiotic ◽  
Antibiotic Delivery

Mannitol, a polyalcohol bacterial metabolite, has been shown to activate dormant persister cells within bacterial biofilm. This study sought to evaluate an injectable blend of mannitol, chitosan, and polyethylene glycol for delivery of antibiotics and mannitol for eradication of Staphylococcal biofilm. Mannitol blends were injectable and had decreased dissociation and degradation in the enzyme lysozyme compared to blends without mannitol. Vancomycin and amikacin eluted in a burst response, with active concentrations extended to seven days compared to five days for blends without mannitol. Mannitol eluted from the paste in a burst the first day and continued through Day 4. Eluates from the mannitol pastes with and without antibiotics decreased viability of established S. aureus biofilm by up to 95.5% compared to blends without mannitol, which only decreased biofilm when loaded with antibiotics. Cytocompatibility tests indicated no adverse effects on viability of fibroblasts. In vivo evaluation of inflammatory response revealed mannitol blends scored within the 2–4 range at Week 1 (2.6 ± 1.1) and at Week 4 (3.0 ± 0.8), indicative of moderate inflammation and comparable to non-mannitol pastes (p = 0.065). Clinically, this paste could be loaded with clinician-selected antibiotics and used as an adjunctive therapy for musculoskeletal infection prevention and treatment.

Enzymatically crosslinked epsilon-poly-l-lysine hydrogels with inherent antibacterial properties for wound infection prevention

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8620-8627 ◽  
Author(s):  
Rui Wang ◽  
De-lei Xu ◽  
Lei Liang ◽  
Ting-ting Xu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Wound Infection ◽  
Infection Prevention ◽  
Enzymatic Catalysis ◽  
Antibacterial Properties

Anin situforming hydrogel derived from epsilon-poly-l-lysine was crosslinked by the enzymatic catalysis method and showed excellent antibacterial properties for wound infection prevention.

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