Design & Development of Quaternary Amine Compounds: Corrosion Inhibitors with Improved Environmental Profiles

2005 ◽  
Author(s):  
Laxmikant Tiwari
Keyword(s):  
Corrosion Inhibitors ◽  
Design Development ◽  
Quaternary Amine ◽  
Amine Compounds

scholarly journals Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii

mBio ◽  
2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Gregory A. Knauf ◽  
Ashley L. Cunningham ◽  
Misha I. Kazi ◽  
Ian M. Riddington ◽  
Alexander A. Crofts ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Acinetobacter Baumannii ◽  
Pathogenic Bacteria ◽  
Bacterial Pathogen ◽  
Multidrug Resistant ◽  
Antimicrobial Action ◽  
Quaternary Amine ◽  
Low Concentrations ◽  
High Concentrations ◽  
Amine Compounds

ABSTRACTQuaternary amine compounds (QAC) are potent antimicrobials used to prevent the spread of pathogenic bacteria. While they are known for their membrane-damaging properties, QAC action has been suggested to extend beyond the surface to intracellular targets. Here we characterize the range of action of the QAC biocide benzalkonium chloride (BZK) against the bacterial pathogenAcinetobacter baumannii. At high concentrations, BZK acts through membrane disruption, but at low concentrations we show that wide-spread protein aggregation is associated with BZK-induced cell death. Resistance to BZK is found to develop through ribosomal protein mutations that protectA. baumanniiagainst BZK-induced protein aggregation. The multifunctional impact of BZK led us to discover that alternative QAC structures, with low human toxicity, retain potent action against multidrug-resistantA. baumannii,Staphylococcus aureus, andClostridium difficileand present opportunities for their development as antibiotics.IMPORTANCEQuaternary amine compounds (QACs) are widely used to prevent the spread of bacterial pathogens, but our understanding of their mode of action is incomplete. Here we describe disruption of bacterial proteostasis as an unrecognized action of QAC antimicrobial action and uncover the potential of diverse QAC structures to act as multitarget antibiotics.

scholarly journals Theoretical and Experimental Studies of Different Amine Compounds as Corrosion Inhibitors for Aluminum in Hydrochloric Acid

2020 ◽  
Vol 11 (2) ◽  
pp. 9772-9785
Keyword(s):  
Hydrochloric Acid ◽  
Acid Solution ◽  
Quantum Chemical ◽  
Density Functional ◽  
Corrosion Inhibitors ◽  
Energy Gap ◽  
Experimental Studies ◽  
High Efficient ◽  
Aluminum Corrosion ◽  
Amine Compounds

Density Functional Theory investigations using the B3LYP/6-31G* model have been carried out. Several quantum chemical parameters have been computed to interpret the inhibition activity of 2, 4-dinitrophenylhydrazine, o-phenylenediamine, and hydrazine hydrate. The ranking of the quantum chemical calculations classifies 2, 4-Dinitrophenylhydrazine as high efficient inhibitor among the studied molecules. The correspondence of the lowest energy gap (ΔE = 4.27 eV) for the calculated value (88.9%) of the highest inhibition efficiency (%IE) of 2, 4 Dinitrophenylhydrazine. Therefore, in parallel, the experimental inhibition of aluminum corrosion was tested using amine compounds in 1M hydrochloric acid solution by means of gravimetry and gasometry measurements. These compounds have been found to act as effective corrosion inhibitors for aluminum in the acid solution, and the best one was 2, 4-dinitrophenylhydrazine, represent one of the salient agreements between experimental and theoretical measurements. The data are showing that this inhibitor is appropriate for Langmuir adsorption isotherm. SEM micrographs indicate that the surface coverage increases in the presence of 0.5 mM of 2, 4-dinitrophenylhydrazine inhibitor, which in turn results in the formation of the adsorbed compound on the metal surface and the surface is covered by an inhibitor layer that effectively controls the dissolution of aluminum.

New corrosion inhibitors for evaporative cooling systems

2013 ◽  
Vol 44 (1) ◽  
pp. 39-54
Author(s):  
A. Wehlmann ◽  
W. Hater ◽  
F. Wolf ◽  
R. Lunkenheimer ◽  
C. Foret ◽  
...  
Keyword(s):  
Corrosion Inhibitors ◽  
Evaporative Cooling ◽  
Cooling Systems
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