Design and Development of Quaternary Amine Compounds: Shale Inhibition With Improved Environmental Profile

2009 ◽  
Author(s):  
Arvind D. Patel
Keyword(s):  
Quaternary Amine ◽  
Design And Development ◽  
Environmental Profile ◽  
Amine Compounds

scholarly journals Exploring the Antimicrobial Action of Quaternary Amines against Acinetobacter baumannii

mBio ◽  
2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Gregory A. Knauf ◽  
Ashley L. Cunningham ◽  
Misha I. Kazi ◽  
Ian M. Riddington ◽  
Alexander A. Crofts ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Acinetobacter Baumannii ◽  
Pathogenic Bacteria ◽  
Bacterial Pathogen ◽  
Multidrug Resistant ◽  
Antimicrobial Action ◽  
Quaternary Amine ◽  
Low Concentrations ◽  
High Concentrations ◽  
Amine Compounds

ABSTRACTQuaternary amine compounds (QAC) are potent antimicrobials used to prevent the spread of pathogenic bacteria. While they are known for their membrane-damaging properties, QAC action has been suggested to extend beyond the surface to intracellular targets. Here we characterize the range of action of the QAC biocide benzalkonium chloride (BZK) against the bacterial pathogenAcinetobacter baumannii. At high concentrations, BZK acts through membrane disruption, but at low concentrations we show that wide-spread protein aggregation is associated with BZK-induced cell death. Resistance to BZK is found to develop through ribosomal protein mutations that protectA. baumanniiagainst BZK-induced protein aggregation. The multifunctional impact of BZK led us to discover that alternative QAC structures, with low human toxicity, retain potent action against multidrug-resistantA. baumannii,Staphylococcus aureus, andClostridium difficileand present opportunities for their development as antibiotics.IMPORTANCEQuaternary amine compounds (QACs) are widely used to prevent the spread of bacterial pathogens, but our understanding of their mode of action is incomplete. Here we describe disruption of bacterial proteostasis as an unrecognized action of QAC antimicrobial action and uncover the potential of diverse QAC structures to act as multitarget antibiotics.

A case study on use of personas in design and development of an audit management system

2007 ◽  
Author(s):  
Pallavi Dharwada ◽  
Joel S. Greenstein ◽  
Anand K. Gramopadhye ◽  
Steve J. Davis
Keyword(s):  
Management System ◽  
Design And Development ◽  
Audit Management

Architectures for Architects

1993 ◽  
Vol 32 (01) ◽  
pp. 12-13 ◽  
Author(s):  
M. A. Musen
Keyword(s):  
Decision Support ◽  
Decision Support Systems ◽  
Clinical Decision Support ◽  
Support Systems ◽  
Clinical Decision Support Systems ◽  
Clinical Decision ◽  
Design And Development

Abstract:Response to Heathfield HA, Wyatt J. Philosophies for the design and development of clinical decision-support systems. Meth Inform Med 1993; 32: 1-8.

Sign in / Sign up

Export Citation Format

Share Document