Platelet-Rich Plasma Inhibits Demineralized Bone Matrix-Induced Bone Formation in Nude Mice

2007 ◽  
Vol 89 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Don M. Ranly ◽  
Christoph H. Lohmann ◽  
Domenico Andreacchio ◽  
Barbara D. Boyan ◽  
Zvi Schwartz
Keyword(s):  
Bone Formation ◽  
Nude Mice ◽  
Demineralized Bone Matrix ◽  
Platelet Rich Plasma ◽  
Bone Matrix ◽  
Demineralized Bone

Platelet-Rich Plasma Inhibits Demineralized Bone Matrix-Induced Bone Formation in Nude Mice

2007 ◽  
Vol 89 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Don M. Ranly ◽  
Barbara D. Boyan ◽  
Zvi Schwartz ◽  
Christoph H. Lohmann ◽  
Domenico Andreacchio
Keyword(s):  
Bone Formation ◽  
Nude Mice ◽  
Demineralized Bone Matrix ◽  
Platelet Rich Plasma ◽  
Bone Matrix ◽  
Demineralized Bone

Tissue Engineering of Bone by Osteoinductive Biomaterials

MRS Bulletin ◽  
1996 ◽  
Vol 21 (11) ◽  
pp. 36-39 ◽  
Author(s):  
Ugo Ripamonti ◽  
Nicolaas Duneas
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Type I Collagen ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Mesenchymal Cells ◽  
Tissue Response ◽  
Type I ◽  
New Bone Formation ◽  
Demineralized Bone

Recent advances in materials science and biotechnology have given birth to the new and exciting field of tissue engineering, in which the two normally disparate fields are merging into a profitable matrimony. In particular the use of biomaterials capable of initiating new bone formation via a process called osteoinduction is leading to quantum leaps for the tissue engineering of bone.The classic work of Marshall R. Urist and A. Hari Reddi opened the field of osteoinductive biomaterials. Urist discovered that, upon implantation of devitalized, demineralized bone matrix in the muscle of experimental animals, new bone formation occurs within two weeks, a phenomenon he described as bone formation by induction. The tissue response elicited by implantation of demineralized bone matrix in muscle or under the skin includes activation and migration of undifferentiated mesenchymal cells by chemotaxis, anchoragedependent cell attachment to the matrix, mitosis and proliferation of mesenchymal cells, differentiation of cartilage, mineralization of the cartilage, vascular invasion of the cartilage, differentiation of osteoblasts and deposition of bone matrix, and finally mineralization of bone and differentiation of marrow in the newly developed ossicle.The osteoinductive ability of the extracellular matrix of bone is abolished by the dissociative extraction of the demineralized matrix, but is recovered when the extracted component, itself inactive, is reconstituted with the inactive residue—mainly insoluble collagenous bone matrix. This important experiment showed that the osteoinductive signal resides in the solubilized component but needs to be reconstituted with an appropriate carrier to restore the osteoinductive activity. In this case, the carrier is the insoluble collagenous bone matrix—mainly crosslinked type I collagen.

Effect of Bupivacaine on Muscle Tissues and New Bone Formation Induced by Demineralized Bone Matrix Gelatin

1991 ◽  
Vol 141 (1) ◽  
pp. 1-7 ◽  
Author(s):  
K. Yamashita ◽  
Y. Horisaka ◽  
Y. Okamoto ◽  
Y. Yoshimura ◽  
N. Matsumoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
New Bone Formation ◽  
Muscle Tissues ◽  
Demineralized Bone

Paper # 92: Demineralized Bone Matrix and Platelet-Rich Plasma for Osteochondral Defects of the Talus– An Experimental Goat Study

2011 ◽  
Vol 27 (10) ◽  
pp. e127
Author(s):  
Christiaan J.A. Van Bergen ◽  
Murat Özdemir ◽  
Gino M.M.J. Kerkhoffs ◽  
Clara M. Korstjens ◽  
Leo J. van Ruijven ◽  
...  
Keyword(s):  
Demineralized Bone Matrix ◽  
Platelet Rich Plasma ◽  
Bone Matrix ◽  
Osteochondral Defects ◽  
Demineralized Bone

The Effect of Thrombin Activation of Platelet-Rich Plasma on Demineralized Bone Matrix Osteoinductivity

2009 ◽  
Vol 91 (6) ◽  
pp. 1459-1470 ◽  
Author(s):  
Bo Han ◽  
Jennifer Woodell-May ◽  
Michael Ponticiello ◽  
Zhi Yang ◽  
Marcel Nimni
Keyword(s):  
Demineralized Bone Matrix ◽  
Platelet Rich Plasma ◽  
Bone Matrix ◽  
Thrombin Activation ◽  
Demineralized Bone
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