scholarly journals Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus

2020 ◽  
Vol 9 (2) ◽  
pp. 428-436 ◽  
Author(s):  
Yulong Zhou ◽  
Zhicheng Zhang ◽  
Jie Tian ◽  
Shaoyun Xiong
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Factors Associated ◽  
Novel Coronavirus

scholarly journals Early Prediction of Disease Progression in 2019 Novel Coronavirus Pneumonia Patients Outside Wuhan with CT and Clinical Characteristics

2020 ◽  
Author(s):  
Zhichao Feng ◽  
Qizhi Yu ◽  
Shanhu Yao ◽  
Lei Luo ◽  
Junhong Duan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Disease Progression ◽  
Severity Score ◽  
Clinical Characteristics ◽  
Lung Involvement ◽  
Multivariate Logistic Regression ◽  
Short Term ◽  
Progressive Group ◽  
Novel Coronavirus

AbstractObjectiveTo determine the predictive value of CT and clinical characteristics for short-term disease progression in patients with 2019 novel coronavirus pneumonia (NCP).Materials and Methods224 patients with confirmed 2019 novel coronavirus (COVID-19) infection outside Wuhan who had chest CT examinations were retrospectively screened. Clinical data were obtained from electronic medical records. CT images were reviewed and scored for lesion distribution, lobe and segment involvement, ground-glass opacities, consolidation, and interstitial thickening. All included patients with moderate NCP were observed for at least 14 days from admission to determine whether they exacerbated to severe NCP (progressive group) or not (stable group). CT and clinical characteristics between the two groups were compared, and multivariate logistic regression and sensitivity analyses were performed to identify the risk factors for developing severe NCP.ResultsA total of 141 patients with moderate NCP were included, of which 15 (10.6%) patients developed severe NCP during hospitalization and assigned to the progressive group. Multivariate logistic regression analysis showed that higher neutrophil-to-lymphocyte ratio (NLR) (odds ratio [OR] and 95% confidence interval [CI], 1.26 [1.04-1.53]; P = 0.018) and CT severity score (OR and 95% CI, 1.25 [1.08-1.46]; P = 0.004) on admission were independent predictors for progression to severe NCP, and sensitivity analysis confirmed the consistent results in nonimported patients but not in imported patients. However, no significant difference in lung involvement was found on CT between imported and nonimported patients (all P > 0.05). Patients who were admitted more than 4 days from symptom onset tended to have more severe lung involvement. Spearman correlation analysis showed the close association between CT severity score and inflammatory indexes (r = 0.17∼0.47, all P < 0.05).ConclusionCT severity score was associated with inflammatory levels and higher NLR and CT severity score on admission were independent risk factors for short-term progression in patients with NCP outside Wuhan. Furthermore, early admission and surveillance by CT should be recommended to improve clinical outcomes.

scholarly journals Maximum chest CT score predicts progression to severe illness in patients with COVID-19: a retrospective study from Wuhan, China

2020 ◽  
Author(s):  
Jianwei Xiao ◽  
Xiang Li ◽  
Yuanliang Xie ◽  
Zengfa Huang ◽  
Yi Ding ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Clinical Laboratory ◽  
Characteristic Curve ◽  
Severe Illness ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Factors Associated ◽  
Radiological Data ◽  
Symptom Progression

Abstract Background: We investigated the clinical course and imaging findings of hospitalized patients who were initially diagnosed with moderate COVID-19 symptoms to identify risk factors associated with progression to severe/critical symptoms.Methods: This study was a retrospective single-center study at The Central Hospital of Wuhan. 243 patients with confirmed COVID­19 pneumonia were enrolled in the analysis, of which 40 patients progressed from moderate to severe/critical symptoms during follow up. Demographic, clinical, laboratory and radiological data were extracted from electronic medical records and compared between moderate and severe/critical symptom types. Univariable and multivariable logistic regressions were used to identify the risk factors associated with symptom progression.Results: Patients with severe/critical symptoms were older (p＜0.001) and more often male (p=0.046). We found that the combination of chronic obstructive pulmonary disease and high maximum CT scores was associated with disease progression. Maximum CT scores (≥11) had the greatest predictive value for disease progression. The area under the receiver operating characteristic curve (ROC) was 0.861 (95% CI: 0.811-0.902).Conclusions: Maximum CT scores and COPD are associated with patient deterioration. Maximum CT scores (≥11) are associated with severe illness.

scholarly journals Risk factors for illness severity in patients with COVID-19 pneumonia: a prospective cohort study

2020 ◽  
Author(s):  
Nannan Zhang ◽  
Hairong Zhang ◽  
Yanhua Tang ◽  
Hao Zhang ◽  
Aiying Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Severity ◽  
Case Series ◽  
Severity Of Illness ◽  
Illness Severity ◽  
Laboratory Findings ◽  
Factors Associated ◽  
Detection And Identification ◽  
Disease Hospital ◽  
Novel Coronavirus

Abstract Background Although COVID-19 pneumonia is spreading internationally, knowledge regarding the factors associated with the illness severity of patients remains limited. We aimed to identify the factors associated with the disease severity of patients with COVID-19 pneumonia induced by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We prospectively enrolled a single-center case series of adult patients with COVID-19 admitted to the Infectious Disease Hospital of Jining, Jining City, Shandong Province, China, from January 24 to March 1, 2020. Demographics, clinical characteristics, and laboratory findings were compared to investigate the risk factors related with the disease severity of COVID-19 pneumonia patients. Results We included a total of 78 patients with COVID-19 pneumonia, of whom 6 had the severe type. As compared to a moderately ill cohort, our analysis showed that shortness of breath, fatigue, neutrophil percentages > 70%, neutrophil counts > 6.3 × 10 9 /L, lymphocyte percentages < 20%, lymphocyte counts < 1.0 × 10 9 /L, platelet < 100 × 10 9 /L, C-reactive protein (CRP) > 10 mg/L, neutrophil to platelet ratio (NPR) > 2.3, neutrophil to lymphocyte ratio (NLR) > 3.9, aspartate aminotransferase (AST) > 40 U/L, albumin < 40 g/L, lactate dehydrogenase (LDH) > 245 U/L, and glucose > 6.1 mmol/L were predictors of disease severity in COVID-19 pneumonia. In the sex-, age-, and comorbid illness-matched case-control study, neutrophil percentages > 70%, neutrophil counts > 6.3 × 10 9 /L, lymphocyte percentages < 20%, NPR > 2.3, NLR > 3.9, albumin < 40 g/L, and LDH > 245 U/L remained associated with the early detection and identification of severe patients. Conclusion We demonstrated that neutrophil percentages > 70%, neutrophil counts > 6.3×10 9 /L, lymphocyte percentages < 20%, NPR > 2.3, NLR > 3.9, albumin < 40 g/L, and LDH > 245 U/L might predict the severity of illness in patients with COVID-19 pneumonia.

scholarly journals Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka

2011 ◽  
Vol 17 (3) ◽  
pp. 191-198 ◽  
Author(s):  
Lalantha Senevirathna ◽  
Tilak Abeysekera ◽  
Shanika Nanayakkara ◽  
Rohana Chandrajith ◽  
Neelakanthi Ratnatunga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Disease Progression ◽  
Factors Associated ◽  
Uncertain Etiology

scholarly journals Risk Factors Associated with Mortality Among Patients with Novel Coronavirus Disease (COVID-19) in Africa

2020 ◽  
Author(s):  
Mustapha Mohammed ◽  
Surajuddeen Muhammad ◽  
Fatima Zaji Mohammed ◽  
Sagir Mustapha ◽  
Abubakar Sha’aban ◽  
...  
Keyword(s):  
Risk Factors ◽  
Factors Associated ◽  
Novel Coronavirus

scholarly journals Factors Affecting the Prognosis of Children with Medulloblastoma: A Single Institution Retrospective Analysis of 40 Cases

2017 ◽  
Vol 3 (1) ◽  
pp. 16-27
Author(s):  
Jianzhong Yu ◽  
We Shi ◽  
Hao Li
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Cox Regression ◽  
Molecular Subtype ◽  
Postoperative Radiotherapy ◽  
Significant Risk ◽  
Postoperative Treatment ◽  
Karnofsky Performance Scale ◽  
Cox Regression Analysis ◽  
Factors Associated

Few studies have investigated the factors associated with the prognosis of children with medulloblastoma. This retrospective observational study evaluated the association of molecular subtype, clinical characteristics, and pathological types with the outcomes of children with medulloblastoma. This study included 40 patients with medulloblastoma who underwent surgical resection at the Affiliated Children's Hospital of Fudan University between January 2004 and June 2014. The primary outcome was overall survival (OS). Risk factors associated with survival, disease progression, and recurrence were analyzed by univariate Cox regression analysis; the identified significant risk factors were further analyzed by Kaplan-Meier survival curves. Immunohistochemistry analysis of Yes-associated protein 1 (YAP1) and GRB2-associated protein 1 (GAB1) was used for medulloblastoma subtype identification; 20% of tumors were the WNT subtype, and 32.5% were the SHH subtype, with the remainder being non-SHH/WNT. Factors associated with OS included M stage, calcification, cerebrospinal fluid fistula, postoperative treatment (radiotherapy, chemotherapy, or both), postoperative Karnofsky Performance Scale score, and molecular subtype (P < 0.044). Patients with the WNT subtype had better survival outcomes (hazard ratio [HR] = 0.16, 95% confidence interval [CI]: 0.05–0.58). Number of symptoms, M stage, and postoperative radiotherapy were associated with disease progression (P ≤ 0.033). The risk of recurrence increased with advanced M stage (HR = 30.71; 95% CI: 3.92—240.44, P = 0.001). Patients receiving both chemotherapy and radiotherapy were less likely to have a recurrence (P = 0.040). Molecular subtyping of medulloblastoma was more predictive of survival than histopathology in patients undergoing adjuvant therapy.

COVID Smell Tracker: A research-based mobile application to study smell loss in subjects with COVID-19 (Preprint)

2021 ◽  
Author(s):  
Aykut Unsal
Keyword(s):  
Risk Factors ◽  
Smart Phone ◽  
Mobile App ◽  
Blood Type ◽  
Factors Associated ◽  
Younger Age ◽  
The World ◽  
Novel Method ◽  
Novel Coronavirus ◽  
Smell Loss

BACKGROUND Smell loss has been an established symptom of the novel coronavirus. Despite this, the risk factors associated with potential smell loss has not been clearly established. An app was developed and utilized to collect demographics and subjective otolaryngology symptoms from volunteers across the world in order to determine outcomes and risk factors as it pertains specifically to anosmia. OBJECTIVE COVID Smell Tracker” is a smart phone application (app) developed to elucidate the onset, duration and risk factors associated with COVID-related smell loss. METHODS The app is publicly available on smartphone devices (www.covidsmelltracker.org). Users complete surveys around demographics, medical history, COVID status and symptomology. Deidentified responses were collated and analyzed using descriptive statistics. RESULTS Of the 266 users included, the majority were located in Europe (43%) and North America (33%). Male, Caucasian users were most common (54.9% and 61.7% respectively), followed by Indian (10.5%) and Latino (9.4%). The majority of users reported no COVID testing (63%). 164 users reported COVID-related symptoms, and 57% of them reported olfactory dysfunction. User whom were younger age (p = 0.0003) and with type A and B blood types (p = 0.021) experienced smell loss at higher frequencies. Dysgeusia was associated with 28-34% of patients with concomitant smell loss, versus 6%-9% in users without. Smell loss was described ass “sudden” (63%), occurring on average 3 days following the onset of any other symptom. Of those that reported resolution of their smell loss, 50% resolved in 1 week, with 75% resolution reported within 1 month. CONCLUSIONS The results herein correlate with other established COVID-related studies, despite relying on purely volunteered data from participants from around the world. This is the first study to suggest an association of age and blood type with smell loss, and requires further investigation. Mobile app use offers a novel method for safe, remote and granular insight into those suffering from infectious diseases like COVID-19.

Risk factors associated with substance use

2014 ◽  
Author(s):  
Ariel M. Barber ◽  
Alexandra Crouch ◽  
Stephen Campbell
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Factors Associated

A Six Year Prospective Study of Fibrinogen and Other Risk Factors Associated with Mortality in Stable Claudicants

1992 ◽  
Vol 68 (03) ◽  
pp. 261-263 ◽  
Author(s):  
A K Banerjee ◽  
J Pearson ◽  
E L Gilliland ◽  
D Goss ◽  
J D Lewis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intermittent Claudication ◽  
Fibrinogen Level ◽  
Past History ◽  
Fold Increase ◽  
Arterial Disease ◽  
Plasma Fibrinogen ◽  
Plasma Fibrinogen Level ◽  
Factors Associated ◽  
Probability Of Death

SummaryA total of 333 patients with stable intermittent claudication at recruitment were followed up for 6 years to determine risk factors associated with subsequent mortality. Cardiovascular diseases were the underlying cause of death in 78% of the 114 patients who died. The strongest independent predictor of death during the follow-up period was the plasma fibrinogen level, an increase of 1 g/l being associated with a nearly two-fold increase in the probability of death within the next 6 years. Age, low ankle/brachial pressure index and a past history of myocardial infarction also increased the probability of death during the study period. The plasma fibrinogen level is a valuable index of those patients with stable intermittent claudication at high risk of early mortality. The results also provide further evidence for the involvement of fibrinogen in the pathogenesis of arterial disease.

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