scholarly journals Disease progression patterns and risk factors associated with mortality in deceased patients with COVID‐19 in Hubei Province, China

2020 ◽  
Vol 8 (4) ◽  
pp. 584-594 ◽  
Author(s):  
Liang Chen ◽  
Song Liu ◽  
Juncai Tian ◽  
Haisong Pan ◽  
Yu Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Hubei Province ◽  
Factors Associated ◽  
Progression Patterns

scholarly journals Maximum chest CT score predicts progression to severe illness in patients with COVID-19: a retrospective study from Wuhan, China

2020 ◽  
Author(s):  
Jianwei Xiao ◽  
Xiang Li ◽  
Yuanliang Xie ◽  
Zengfa Huang ◽  
Yi Ding ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Clinical Laboratory ◽  
Characteristic Curve ◽  
Severe Illness ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Factors Associated ◽  
Radiological Data ◽  
Symptom Progression

Abstract Background: We investigated the clinical course and imaging findings of hospitalized patients who were initially diagnosed with moderate COVID-19 symptoms to identify risk factors associated with progression to severe/critical symptoms.Methods: This study was a retrospective single-center study at The Central Hospital of Wuhan. 243 patients with confirmed COVID­19 pneumonia were enrolled in the analysis, of which 40 patients progressed from moderate to severe/critical symptoms during follow up. Demographic, clinical, laboratory and radiological data were extracted from electronic medical records and compared between moderate and severe/critical symptom types. Univariable and multivariable logistic regressions were used to identify the risk factors associated with symptom progression.Results: Patients with severe/critical symptoms were older (p＜0.001) and more often male (p=0.046). We found that the combination of chronic obstructive pulmonary disease and high maximum CT scores was associated with disease progression. Maximum CT scores (≥11) had the greatest predictive value for disease progression. The area under the receiver operating characteristic curve (ROC) was 0.861 (95% CI: 0.811-0.902).Conclusions: Maximum CT scores and COPD are associated with patient deterioration. Maximum CT scores (≥11) are associated with severe illness.

scholarly journals Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China

2020 ◽  
Author(s):  
Ling Hu ◽  
Shaoqiu Chen ◽  
Yuanyuan Fu ◽  
Zitong Gao ◽  
Hui Long ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Clinical Outcomes ◽  
Clinical Decision Making ◽  
Troponin I ◽  
Retrospective Chart Review ◽  
Hubei Province ◽  
Rank Test ◽  
Current Standard ◽  
Factors Associated

ABSTRACTBackgroundWith evidence of sustained transmission in more than 190 countries, coronavirus disease 2019 (COVID-19) has been declared a global pandemic. As such, data are urgently needed about risk factors associated with clinical outcomes.MethodsA retrospective chart review of 323 hospitalized patients with COVID-19 in Wuhan was conducted. Patients were classified into three disease severity groups (non-severe, severe, and critical), based on their initial clinical presentation. Clinical outcomes were designated as favorable and unfavorable, based on disease progression and response to treatments. Logistic regression models were performed to identify factors associated with clinical outcomes, and log-rank test was conducted for the association with clinical progression.ResultsCurrent standard treatments did not show significant improvement on patient outcomes in the study. By univariate logistic regression model, 27 risk factors were significantly associated with clinical outcomes. Further, multivariate regression indicated that age over 65 years, smoking, critical disease status, diabetes, high hypersensitive troponin I (>0.04 pg/mL), leukocytosis (>10 × 109/L) and neutrophilia (>75 × 109/L) predicted unfavorable clinical outcomes. By contrast, the use of hypnotics was significantly associated with favorable outcomes. Survival analysis also confirmed that patients receiving hypnotics had significantly better survival.ConclusionsTo our knowledge, this is the first indication that hypnotics could be an effective ancillary treatment for COVID-19. We also found that novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. Overall, our study provides useful data to guide early clinical decision making to reduce mortality and improve clinical outcomes of COVID-19.(Funded by the Natural Science Foundation of Hubei Province ZRMS2019000029 and the Top Youth Talent Program in Hubei Province.)

scholarly journals Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: a cohort study in Medawachchiya, Sri Lanka

2011 ◽  
Vol 17 (3) ◽  
pp. 191-198 ◽  
Author(s):  
Lalantha Senevirathna ◽  
Tilak Abeysekera ◽  
Shanika Nanayakkara ◽  
Rohana Chandrajith ◽  
Neelakanthi Ratnatunga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Disease Progression ◽  
Factors Associated ◽  
Uncertain Etiology

scholarly journals Factors Affecting the Prognosis of Children with Medulloblastoma: A Single Institution Retrospective Analysis of 40 Cases

2017 ◽  
Vol 3 (1) ◽  
pp. 16-27
Author(s):  
Jianzhong Yu ◽  
We Shi ◽  
Hao Li
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Cox Regression ◽  
Molecular Subtype ◽  
Postoperative Radiotherapy ◽  
Significant Risk ◽  
Postoperative Treatment ◽  
Karnofsky Performance Scale ◽  
Cox Regression Analysis ◽  
Factors Associated

Few studies have investigated the factors associated with the prognosis of children with medulloblastoma. This retrospective observational study evaluated the association of molecular subtype, clinical characteristics, and pathological types with the outcomes of children with medulloblastoma. This study included 40 patients with medulloblastoma who underwent surgical resection at the Affiliated Children's Hospital of Fudan University between January 2004 and June 2014. The primary outcome was overall survival (OS). Risk factors associated with survival, disease progression, and recurrence were analyzed by univariate Cox regression analysis; the identified significant risk factors were further analyzed by Kaplan-Meier survival curves. Immunohistochemistry analysis of Yes-associated protein 1 (YAP1) and GRB2-associated protein 1 (GAB1) was used for medulloblastoma subtype identification; 20% of tumors were the WNT subtype, and 32.5% were the SHH subtype, with the remainder being non-SHH/WNT. Factors associated with OS included M stage, calcification, cerebrospinal fluid fistula, postoperative treatment (radiotherapy, chemotherapy, or both), postoperative Karnofsky Performance Scale score, and molecular subtype (P < 0.044). Patients with the WNT subtype had better survival outcomes (hazard ratio [HR] = 0.16, 95% confidence interval [CI]: 0.05–0.58). Number of symptoms, M stage, and postoperative radiotherapy were associated with disease progression (P ≤ 0.033). The risk of recurrence increased with advanced M stage (HR = 30.71; 95% CI: 3.92—240.44, P = 0.001). Patients receiving both chemotherapy and radiotherapy were less likely to have a recurrence (P = 0.040). Molecular subtyping of medulloblastoma was more predictive of survival than histopathology in patients undergoing adjuvant therapy.

Risk factors associated with substance use

2014 ◽  
Author(s):  
Ariel M. Barber ◽  
Alexandra Crouch ◽  
Stephen Campbell
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Factors Associated

A Six Year Prospective Study of Fibrinogen and Other Risk Factors Associated with Mortality in Stable Claudicants

1992 ◽  
Vol 68 (03) ◽  
pp. 261-263 ◽  
Author(s):  
A K Banerjee ◽  
J Pearson ◽  
E L Gilliland ◽  
D Goss ◽  
J D Lewis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intermittent Claudication ◽  
Fibrinogen Level ◽  
Past History ◽  
Fold Increase ◽  
Arterial Disease ◽  
Plasma Fibrinogen ◽  
Plasma Fibrinogen Level ◽  
Factors Associated ◽  
Probability Of Death

SummaryA total of 333 patients with stable intermittent claudication at recruitment were followed up for 6 years to determine risk factors associated with subsequent mortality. Cardiovascular diseases were the underlying cause of death in 78% of the 114 patients who died. The strongest independent predictor of death during the follow-up period was the plasma fibrinogen level, an increase of 1 g/l being associated with a nearly two-fold increase in the probability of death within the next 6 years. Age, low ankle/brachial pressure index and a past history of myocardial infarction also increased the probability of death during the study period. The plasma fibrinogen level is a valuable index of those patients with stable intermittent claudication at high risk of early mortality. The results also provide further evidence for the involvement of fibrinogen in the pathogenesis of arterial disease.

Risk factors associated with primary and secondary reduced libido in male patients with sexual dysfunction

2013 ◽  
Author(s):  
Giovanni Corona ◽  
Giulia Rastrelli ◽  
Emmanuele Jannini ◽  
Linda Vignozzi ◽  
Edoardo Mannucci ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sexual Dysfunction ◽  
Factors Associated ◽  
Male Patients

Population level risk factors associated with childhood obesity

2019 ◽  
Author(s):  
Claire Beynon ◽  
Nora Pashyan ◽  
Elizabeth Fisher ◽  
Dougal Hargreaves ◽  
Linda Bailey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Obesity ◽  
Population Level ◽  
Factors Associated
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