Dr. Jun Yu: biomarkers in pancreatic cancer: recent advances and foreseeable future development

2018 ◽  
Vol 1 ◽  
pp. 18-18
Author(s):  
Crystal Yan
Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4844
Author(s):  
Mareike Waldenmaier ◽  
Tanja Seibold ◽  
Thomas Seufferlein ◽  
Tim Eiseler

Even with all recent advances in cancer therapy, pancreatic cancer still has a dismal 5-year survival rate of less than 7%. The most prevalent tumor subtype is pancreatic ductal adenocarcinoma (PDAC). PDACs display an extensive crosstalk with their tumor microenvironment (TME), e.g., pancreatic stellate cells, but also immune cells to regulate tumor growth, immune evasion, and metastasis. In addition to crosstalk in the local TME, PDACs were shown to induce the formation of pre-metastatic niches in different organs. Recent advances have attributed many of these interactions to intercellular communication by small extracellular vesicles (sEVs, exosomes). These nanovesicles are derived of endo-lysosomal structures (multivesicular bodies) with a size range of 30–150 nm. sEVs carry various bioactive cargos, such as proteins, lipids, DNA, mRNA, or miRNAs and act in an autocrine or paracrine fashion to educate recipient cells. In addition to tumor formation, progression, and metastasis, sEVs were described as potent biomarker platforms for diagnosis and prognosis of PDAC. Advances in sEV engineering have further indicated that sEVs might once be used as effective drug carriers. Thus, extensive sEV-based communication and applications as platform for biomarker analysis or vehicles for treatment suggest a major impact of sEVs in future PDAC research.


2013 ◽  
Vol 781-784 ◽  
pp. 1219-1223 ◽  
Author(s):  
Jiang Ping Meng ◽  
Cheng Bo Hu ◽  
Fei Yue Wu

Benzimidazole compounds are known to possess varied biological activities and so far various types of benzimidazole drugs have extensively been used in clinic. Benzimidazole compounds as a antibacterial agents has been a quite rapidly developing and is gradually becoming a relatively independent scientific area. In this paper we presented the recent advances of benzimidazole compounds as antibacterial agents. The perspective of the foreseeable future and potential application of benzimidazole as antibacterial agents are also presented.


2020 ◽  
Vol 8 (15) ◽  
pp. 4988-5014 ◽  
Author(s):  
Bing Wang ◽  
Zhi Bin Zhang ◽  
Shi Peng Zhong ◽  
Zhao Qiang Zheng ◽  
Ping Xu ◽  
...  

This review introduces recent advances in the materials, fabrication and application of pulsed-laser deposition for high performance photo-detectors from an overall perspective. Challenges and future development trends are also discussed.


Pancreas ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 301-316 ◽  
Author(s):  
Murielle Mimeault ◽  
Randall E Brand ◽  
Aaron A Sasson ◽  
Surinder K Batra

2021 ◽  
Vol Volume 13 ◽  
pp. 4251-4262
Author(s):  
Xinzhu Sun ◽  
Dongyan Liu ◽  
Nan Ge ◽  
Jintao Guo ◽  
Sheng Wang ◽  
...  

2021 ◽  
Author(s):  
Michele Bianco

Guided by the results of a preliminary analysis on the effects of the pandemic on international markets, possible and foreseeable future scenarios have been imagined and investigated. With a special focus on Italy and Japan, we will analyse the innovative trends in the world of food that will guide future changes and developments, highlighting new approaches to consumption, the challenges to be faced in the new normal and the opportunities to be seized, under the perspective of the online approach. The objective of this speech is to investigate the evolution of the food experience for Made in Italy and Japanese products, identifying affinities and possible synergies between food and cultural styles, sharing points of reflection for strategic business development.


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