scholarly journals Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

2021 ◽  
Vol Volume 13 ◽  
pp. 4251-4262
Author(s):  
Xinzhu Sun ◽  
Dongyan Liu ◽  
Nan Ge ◽  
Jintao Guo ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Circular Rna ◽  
Diagnosis And Treatment ◽  
Recent Advances ◽  
Potential Use

scholarly journals Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment

Theranostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 2755-2769
Author(s):  
Zeyin Rong ◽  
Jin Xu ◽  
Si Shi ◽  
Zhen Tan ◽  
Qingcai Meng ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Circular Rna ◽  
Diagnosis And Treatment

Potential use of aptamers for diagnosis and treatment of pancreatic cancer

2019 ◽  
Vol 27 (8) ◽  
pp. 853-865 ◽  
Author(s):  
Ge Gao ◽  
Can Liu ◽  
Sona Jain ◽  
Dai Li ◽  
Hai Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Diagnosis And Treatment ◽  
Potential Use

scholarly journals The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Zhao ◽  
Guiping Zhao ◽  
Shuyue Yang ◽  
Shengtao Zhu ◽  
Shutian Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Escape ◽  
Diagnosis And Treatment ◽  
Circular Rnas ◽  
Molecular Heterogeneity ◽  
Bioactive Constituents ◽  
Functional Connections ◽  
Non Coding Rnas ◽  
The Relationship ◽  
Exosomal Rnas

AbstractExosomes are single-membrane, secreted organelles with a diameter of 30–200 nm, containing diverse bioactive constituents, including DNAs, RNAs, proteins, and lipids, with prominent molecular heterogeneity. Extensive studies indicate that exosomal RNAs (e.g., microRNAs, long non-coding RNAs, and circular RNAs) can interact with many types of cancers, associated with several hallmark features like tumor growth, metastasis, and resistance to therapy. Pancreatic cancer (PaCa) is among the most lethal cancers worldwide, emerging as the seventh foremost cause of cancer-related death in both sexes. Hence, revealing the specific pathogenesis and improving the clinical diagnosis and treatment process are urgently required. As the study of exosomes has become an active area of research, the functional connections between exosomes and PaCa have been deeply investigated. Among these, exosomal RNAs seem to play a significant role in the development, diagnosis, and treatment of PaCa. Exosomal RNAs delivery ultimately modulates the various features of PaCa, and many scholars have interpreted how exosomal RNAs contribute to the proliferation, angiogenesis, migration, invasion, metastasis, immune escape, and drug resistance in PaCa. Besides, recent studies emphasize that exosomal RNAs may serve as diagnostic and prognostic biomarkers or therapeutic targets for PaCa. In this review, we will introduce these recent insights focusing on the discoveries of the relationship between exosomal RNAs and PaCa, and the potentially diagnostic and therapeutic applications of exosomes in PaCa.

scholarly journals The Management of Paroxysmal Nocturnal Hemoglobinuria: Recent Advances in Diagnosis and Treatment and New Hope for Patients

2009 ◽  
Vol 46 ◽  
pp. S1-S16 ◽  
Author(s):  
Neal S. Young ◽  
Gabrielle Meyers ◽  
Hubert Schrezenmeier ◽  
Peter Hillmen ◽  
Anita Hill
Keyword(s):  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Diagnosis And Treatment ◽  
Recent Advances
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