scholarly journals Quantification, dietary intake adequacy, and food sources of nutrients involved in the methionine-methylation cycle (choline, betaine, folate, vitamin B6 and vitamin B12) in pregnant women in Spain

2021 ◽  
Author(s):  
Gregorio Varela Moreiras ◽  
Marina Redruello Requejo ◽  
Alejandra Carretero Krüg ◽  
María de Lourdes Samaniego Vaesken ◽  
Teresa Partearroyo Cediel
Keyword(s):  
Dietary Intake ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Vitamin B6 ◽  
Food Sources

scholarly journals Dietary Intake Adequacy and Food Sources of Nutrients Involved in the Methionine-Methylation Cycle in Women of Childbearing Age from the ANIBES Spanish Population

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2958
Author(s):  
Marina Redruello-Requejo ◽  
Alejandra Carretero-Krug ◽  
Paula Rodríguez-Alonso ◽  
María Lourdes Samaniego-Vaesken ◽  
Teresa Partearroyo ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Food Sources ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Younger Women ◽  
Main Food ◽  
Dietary Record ◽  
Methionine Cycle

Growing evidence confirms choline as a critical perinatal nutrient. However, intake levels of choline and betaine among the Spanish fertile population remain unknown. Given their role in one-carbon metabolism with potential epigenetic effects, the aim of the present study was to evaluate the dietary intakes, their adequacy to existing guidelines and the main food sources together with other micronutrients involved in the methylation-methionine cycle (vitamin B6, folates and vitamin B12) in women of childbearing age. The ANIBES study, a cross-sectional study of a representative sample of women of childbearing age (18–45 years, n = 641) resident in Spain, was used. The sample was divided into younger women (18–30 years, n = 251) and older women (31–45 years, n = 390). Dietary intake was assessed by a three-day dietary record by using a tablet device. Total median intakes for the total sample were 303.9 mg/d for choline; 122.6 mg/d for betaine; 1.3 mg/d for vitamin B6; 140.8 μg/d for folates, and 3.8 μg/d for vitamin B12. The older subgroup showed significantly higher choline (p < 0.05), betaine (p < 0.001) and folates (p < 0.05) intakes than younger women. Main food sources for the whole sample were meat and meat products for choline (28.3%), vitamin B6 (25.7%) and vitamin B12 (22.8%); cereals and derivatives (79.9%) for betaine; vegetables (20.0%) for folates. Overall intake adequacy was only observed for vitamin B12, with a very limited number of participants showing adequate intakes for all the other micronutrients. These results illustrate there is a relevant need to raise awareness about optimizing the status of the methionine cycle-related vitamins and cofactors in this potentially vulnerable population.

scholarly journals Dietary Intake and Food Sources of Niacin, Riboflavin, Thiamin and Vitamin B6 in a Representative Sample of the Spanish Population. The ANIBES Study

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 846 ◽  
Author(s):  
Juan Mielgo-Ayuso ◽  
Raquel Aparicio-Ugarriza ◽  
Josune Olza ◽  
Javier Aranceta-Bartrina ◽  
Ángel Gil ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Representative Sample ◽  
Vitamin B6 ◽  
Spanish Population ◽  
Food Sources

Dietary intake and food sources of choline in pregnant women in bloemfontein, South Africa

2020 ◽  
Vol 40 ◽  
pp. 625-626
Author(s):  
L. Robb ◽  
G. Joubert ◽  
M. Jordaan ◽  
J. Osei Ngounda ◽  
C. Walsh
Keyword(s):  
South Africa ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Food Sources

scholarly journals Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Paramita Khairan ◽  
Tomotaka Sobue ◽  
Ehab Salah Eshak ◽  
Ling Zha ◽  
Tetsuhisa Kitamura ◽  
...  
Keyword(s):  
Public Health ◽  
Esophageal Cancer ◽  
Dietary Intake ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Health Center ◽  
Vitamin B6 ◽  
B Vitamins ◽  
Dietary Intakes ◽  
Public Health Center

Abstract Background B vitamins and methionine are essential substrates in the one-carbon metabolism pathway involved in DNA synthesis and methylation. They may have essential roles in cancer development. We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study. Methods We included 87,053 Japanese individuals who completed a food frequency questionnaire and were followed up from 1995–1998 to 2013 and 2015. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by Cox proportional-hazard regression across quintiles of dietary intakes of B vitamins and methionine. Results After 1,456,678 person-years of follow-up, 427 EC cases were documented. The multivariable HR (95% CI) of incident EC in the highest versus lowest quintile of dietary intake of vitamin B12 was 1.75 (1.13–2.71; p-trend=0.01). Stratification analysis based on alcohol consumption showed that higher dietary intakes of vitamin B12 and methionine were associated with an increased risk of EC among never-drinkers; HRs (95% CIs) were 2.82 (1.18–6.74; p-trend=0.009; p-interaction=0.18) and 3.45 (1.32–9.06; p-trend=0.003; p-interaction 0.02) for vitamin B12 and methionine, respectively. Meanwhile, there was no association between vitamin B12 and methionine intake with the risk of EC among drinkers. There were no associations between dietary intake of folate or vitamin B6 and the risk of EC. Conclusion Dietary intake of vitamin B12 was positively associated with the risk of EC in the Japanese population.

scholarly journals Methyl Donor Nutrient Intake and Risk of Type 2 Diabetes: Results from 3 Large US Cohorts (OR15-02-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Kim V E Braun ◽  
Ambika Satija ◽  
Trudy Voortman ◽  
Oscar Franco ◽  
Qi Sun ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Vitamin B12 ◽  
Health Professionals ◽  
Vitamin B6 ◽  
Food Sources ◽  
Health Study ◽  
Vitamin B2

Abstract Objectives DNA methylation may play a role in the development of type 2 diabetes (T2D). DNA methylation can be influenced by methyl donor nutrients such as vitamins B2, B6, B12, folate, and methionine, which are all central to one carbon metabolism. Using 3 large cohorts of US health professionals, we examined whether intake of these nutrients from food or supplements is associated with T2D risk. Methods We included 69,949 women from the Nurses’ Health Study (1984–2012), 90,239 women from the Nurses’ Health Study II (1991–2011), and 40,539 men from the Health Professionals Follow-Up Study (1986–2010). Dietary data were collected every 2–4 years using a validated semi-quantitative FFQ, from which dietary intakes of vitamin B2, vitamin B6, vitamin B12, folate, and methionine were calculated. We used Cox proportional hazards model with time-varying covariates and adjusted for several sociodemographic and lifestyle variables. We also adjusted for cereal fiber, animal protein, polyunsaturated and saturated fatty acids ratio. Food sources of vitamins were additionally adjusted for multivitamin use while supplemental sources of vitamins were adjusted for a measure of overall diet quality. Results During 1763,428 years of follow-up, we documented 8141 T2D cases. In pooled multivariable-adjusted analyses, compared to those in the lowest quintile, those in the highest quintile of vitamins B2 and B6 had a 10% (95% CI 3%–16%) and 11% (95% CI 3%–16%) lower T2D risk, respectively. Total vitamin B12 intake was not associated with T2D. However, when analyses were stratified by source, vitamin B12 from food sources was associated with a higher T2D risk (HR [95% CI] = 1.11 [1.02–1.19]). On the other hand, supplemental vitamin B12 was associated with lower T2D risk (HR [95% CI] for Q5 vs Q1 = 0.92 [0.85–0.98]). We found no evidence for an association between intakes of folate and methionine and T2D risk. Conclusions Our study suggests that higher intakes of vitamin B2 and vitamin B6 are associated with a lower T2D risk. A higher vitamin B12 intake from food seems to be associated with a higher T2D risk, which may be due to consumption of animal products. Funding Sources The analysis was supported by grants from the National Institutes of Health.

scholarly journals Plasma Folate, Vitamin B6 and B12 in Their Relationship to the Presence of Probiotic Strain Bifidobacterium animalis subsp. Lactis HNO19 (DR10TM) Among Indonesian Pregnant Women in Their Third Semester

2019 ◽  
Vol 2 (2) ◽  
pp. 56
Author(s):  
Saptawati Bardosono ◽  
Noroyono Wibowo ◽  
Luciana Budiati Sutanto ◽  
Rima Irwinda ◽  
Rebecca Cannan ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Blood Concentration ◽  
Vitamin B6 ◽  
Probiotic Strain ◽  
Plasma Vitamin ◽  
Third Trimester ◽  
Blood Concentrations ◽  
Bifidobacterium Animalis ◽  
Plasma Folate

Introduction Vitamin B12 plays a role during pregnancy in maintaining folate metabolism. Together with folate and vitamin B6, B12 is involved as a coenzyme in DNA synthesis and various methylation reactions in developing embryos. This study aims to compare plasma folate, vitamin B6 and B12 blood levels with respect to the presence of probiotic strain Bifidobacterium animalis subsp. lactis HNO19 (DR10TM) among pregnant women in Indonesia. Methods: This study is part of a larger study entitled “Effects of Bifidobacterium animalis subsp. lactis HNO19 (DR10TM), inulin, and micronutrient fortified milk on fecal DR10TM, immune markers, and maternal micronutrients among Indonesian pregnant women.” Further analyses were performed using independent-t test or Mann Whitney test, GLM-repeated measures and chi-square test, to compare folate, vitamin B6 and B12 intake and blood concentration during pregnancy with presence (n=22) and absence (n=55) subjects of fecal DR10TM at third trimester. Results: At the first trimesters there was no difference in plasma vitamin B6 and vitamin B12 levels between the two groups, based on the presence or absence of fecal DR10TM. However, at the second and third trimester, vitamin B6 blood concentration (p=0.034 and p=0.001) and vitamin B12 blood concentrations at the third trimester (p=0.035) were significantly higher in the fecal DR10TM positive group, while having a similar vitamin B6 and B12 intake. Conclusion: Consumption of pre- and probiotics during the periconceptional period may be a useful strategy for improving maternal vitamin B’s vitamins, especially vitamin B6 and B12 status and therefore provide benefits for the offspring’s quality of life.

Sign in / Sign up

Export Citation Format

Share Document