Immature, but Not Mature, Dendritic Cells Are More Often Present in Aggressive Periodontitis Than Chronic Periodontitis: An Immunohistochemical Study

2016 ◽  
Vol 87 (12) ◽  
pp. 1499-1507 ◽  
Author(s):  
Raphael J.G. da Motta ◽  
Camila Tirapelli ◽  
Roberto Juns da Silva ◽  
Kelly R.V. Villafuerte ◽  
Luciana Y. Almeida ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Chronic Periodontitis ◽  
Immunohistochemical Study ◽  
Aggressive Periodontitis

scholarly journals Impact of aggressive periodontitis and chronic periodontitis on oral health-related quality of life

2018 ◽  
Vol 32 (0) ◽  
Author(s):  
Alexandre Hugo LLANOS ◽  
Carlos Guillermo Benítez SILVA ◽  
Karina Tamie ICHIMURA ◽  
Estela Sanches REBEIS ◽  
Marcela GIUDICISSI ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Chronic Periodontitis ◽  
Aggressive Periodontitis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Mahdi Kdkhodazadeh ◽  
Mehrdad Hajilooi ◽  
Behzad Houshmand ◽  
Sara Khazaei ◽  
Leila Gholami ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Aggressive Periodontitis ◽  
Genotype Distribution ◽  
Nucleotide Polymorphisms ◽  
Healthy Individuals ◽  
Single Nucleotide ◽  
Genotypic Distribution ◽  
Genotype Frequencies ◽  
Significant Difference ◽  
Polymerase Chain

Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals. Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs). Results. A statistically significant difference was found between the genotypic distribution of the Ser563Asn polymorphism in patients with periodontitis compared to controls (P=0.02). But there were no statistically significant difference between the allele frequencies in the different groups (P=0.05). The other two polymorphisms did not show a statistically significant difference in their allele and genotype frequencies between the groups. There was no statistically significant difference found for any of the polymorphisms allele and genotype distribution in aggressive and chronic periodontitis either. Conclusions. No significant association was found between the polymorphism tested and the subgroups of periodontitis, further research is still necessary to determine whether this polymorphism can be used as a genetic marker of periodontitis.

scholarly journals CD40 up-regulation on dendritic cells correlates with Th17/Treg imbalance in chronic periodontitis in young population

2020 ◽  
Vol 26 (6) ◽  
pp. 482-489
Author(s):  
Xin Su ◽  
Jiahui Zhang ◽  
Xue Qin
Keyword(s):  
Dendritic Cells ◽  
Chronic Periodontitis ◽  
Th17 Cell ◽  
Young Patients ◽  
Serum Levels ◽  
Cd40 Ligand ◽  
Young Population ◽  
Soluble Cd40 Ligand ◽  
Old Patients

We aimed to discover the influence of age on the development of chronic periodontitis and illustrate the molecular mechanism in this process. Blood samples were collected from 63 chronic periodontitis patients and 30 healthy controls. Th17 cell/Foxp3+ regulatory T cell (Treg) ratio and expression of costimulatory molecules in dendritic cells (DCs) were analyzed by flow cytometry. The serum levels of soluble CD40 ligand (CD40L) and IL-17 were examined by ELISA. In young chronic periodontitis patients, the Th17/Treg ratio was significantly higher than that in old patients. CD40 on DCs and serum levels of CD40L and IL-17 were all higher in young chronic periodontitis patients. Mature DCs with high CD40 expression level elevated the Th17/Treg ratio in vitro. During the pathogenesis of chronic periodontitis, young patients had higher Th17/Treg ratio than old patients and this phenomenon was in line with the differential expression levels of CD40 in DCs.

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