EXPRESSION OF MMP-1 AND MMP-9 IN LOCALIZED AGGRESSIVE PERIODONTITIS PATIENTS BEFORE AND AFTER TREATMENT: A CLINICAL AND IMMUNOHISTOCHEMICAL STUDY

2017 ◽  
Vol 63 (1) ◽  
pp. 667-684
Author(s):  
Hala Hazzaa ◽  
Eman Abo Hager
Keyword(s):  
Immunohistochemical Study ◽  
Aggressive Periodontitis ◽  
Before And After ◽  
Localized Aggressive Periodontitis

Comparative evaluation of amoxicillin plus metronidazole and doxycycline alone in the nonsurgical treatment of localized aggressive periodontitis

2014 ◽  
Vol 5 (3) ◽  
pp. 112
Author(s):  
Rajasekhar Nutalapati ◽  
SureshKumar Kasagani ◽  
NarendraDev Jampani ◽  
RameshBabu Mutthineni ◽  
Srikanth Chintala ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Aggressive Periodontitis ◽  
Nonsurgical Treatment ◽  
Localized Aggressive Periodontitis

One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis

Cytokine ◽  
2019 ◽  
Vol 116 ◽  
pp. 27-37 ◽  
Author(s):  
E.S. Martins ◽  
J.B. César-Neto ◽  
E. Albuquerque-Souza ◽  
E.S. Rebeis ◽  
M. Holzhausen ◽  
...  
Keyword(s):  
Aggressive Periodontitis ◽  
Immune Profile ◽  
Localized Aggressive Periodontitis ◽  
One Year

scholarly journals PPAR-Gamma Agonist Pioglitazone Reduced CD68+ but Not CD163+ Macrophage Dermal Infiltration in Obese Psoriatic Patients

PPAR Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Ya. O. Yemchenko ◽  
V. I. Shynkevych ◽  
K. Ye Ishcheikin ◽  
I. P. Kaidashev
Keyword(s):  
Immunohistochemical Study ◽  
Ppar Gamma ◽  
Obese Patients ◽  
Before And After ◽  
Anti Inflammatory ◽  
Inflammatory Profile ◽  
Skin Morphology ◽  
Macrophage Populations ◽  
Inflammatory Action ◽  
M1 And M2 Macrophages

Background. Macrophages are of great importance in the development of obesity and psoriasis. Signaling via PPAR-γ in certain macrophage populations is associated with M2-like features and anti-inflammatory profile. In this research, we evaluated the anti-inflammatory action of pioglitazone by the immunohistochemical study of M1 and M2 macrophages in psoriasis-affected skin in obese patients. Methods. We used immunohistochemistry to characterize CD68+ and CD163+ macrophages and pathomorphological description of skin biopsy, obtained from 6 obese psoriatic patients before and after treatment with 15, 30, and 45 mg pioglitazone, once a day during 6 months. Two patients with conventional therapy and without pioglitazone served as control. Results. Generally, CD163+ cell quantities in psoriasis-affected skin significantly dominated over CD68+ before and after all treatment regiments. Among patients who received pioglitazone, some of them clearly responded to treatment from lowest to highest doses by decreasing CD68+ cells. In the group with 30 mg pioglitazone regiment, we detected a significant reduction of CD68+ cells in dermal infiltrates: CI 95% (16–32) before versus CI 95% (2–7) after treatment. Pioglitazone dose escalation led to certain normalization of skin morphology. Conclusion. The immunohistochemical study allows us to show the anti-inflammatory effect of pioglitazone in psoriatic obese patients, which can be mediated by reducing the number of СD68+ macrophages, but not СD163+ macrophages, in the affected dermis.

scholarly journals Clinical Evaluation of Intrabony Defects in Localized Aggressive Periodontitis Patients with and without Bioglass- An In-vivo Study

2012 ◽  
Vol 10 (1) ◽  
pp. 7-10
Author(s):  
KV Satyanarayana ◽  
BR Anuradha ◽  
G Srikanth ◽  
P Mohan Chandra ◽  
T Anupama ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Test Group ◽  
Gingival Recession ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Defect Depth ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Localized Aggressive Periodontitis ◽  
Attachment Level

Background Aggressive periodontitis is a specific type of periodontitis with clearly identifiable clinical characteristics such as “rapid attachment loss, bone destruction” and “familial aggregation”. Regeneration of mineralized tissues affected by aggressive periodontitis comprises a major scientific and clinical challenge. In recent years some evidence has been provided that bioactive glass is also capable of supporting the regenerative healing of periodontal lesions. Objective The aim of this clinical and radiological prospective study was to evaluate the efficacy of bioactive glass in the treatment of intra-bony defects in patients with localized aggressive periodontitis. Methods Twelve localized aggressive periodontitis patients with bilaterally located three-walled intra-bony defect depth ? 2 mm, preoperative probing depths ? 5 mm were randomly treated either with the bioactive glass or without the bioactive glass. The clinical parameters plaque index, gingival index, probing depth, gingival recession, clinical attachment level, and mobility were recorded prior to surgery as well as 12 months after surgery. Intraoral radiographs were digitized to evaluate the bone defect depth at baseline and 12 months after the surgery. Results After 12 months, a reduction in probing depth of 3.92 + 0.313 mm (P <0.001) and a gain in clinical attachment level of 4.42+0358mm (P <0.001) were registered in the test group. In the control group, a reduction in probing depth of 2.5 +0.230mm (P <0.001) and a gain in clinical attachment level of 2.58 + 0.149 mm (P<0.001) was recorded. Radiographically, the defects were found to be filled by 2.587 + 0.218 mm (P <0.001) in the test group and by 0.1792 + 0.031mm (P <0.001) in the control group. Changes in gingival recession showed no significant differences. . Conclusion Highly significant improvements in the parameters Probing depth, Clinical attachment level, and Bone defect depth were recorded after 12 months, with regenerative material. KATHMANDU UNIVERSITY MEDICAL JOURNAL  VOL.10 | NO. 1 | ISSUE 37 | JAN - MAR 2012 | 11-15 DOI: http://dx.doi.org/10.3126/kumj.v10i1.6906

Immature, but Not Mature, Dendritic Cells Are More Often Present in Aggressive Periodontitis Than Chronic Periodontitis: An Immunohistochemical Study

2016 ◽  
Vol 87 (12) ◽  
pp. 1499-1507 ◽  
Author(s):  
Raphael J.G. da Motta ◽  
Camila Tirapelli ◽  
Roberto Juns da Silva ◽  
Kelly R.V. Villafuerte ◽  
Luciana Y. Almeida ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Chronic Periodontitis ◽  
Immunohistochemical Study ◽  
Aggressive Periodontitis
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