Epidermal Langerhans cells, dermal dendritic cells, and keratinocytes in viral lesions of skin and mucous membranes: an immunohistochemical study

1988 ◽  
Vol 280 (4) ◽  
pp. 220-227 ◽  
Author(s):  
M. Drijkoningen ◽  
C. De Wolf-Peeters ◽  
H. Degreef ◽  
V. Desmet
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Immunohistochemical Study ◽  
Mucous Membranes ◽  
Epidermal Langerhans Cells

scholarly journals Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions

2009 ◽  
Vol 106 (9) ◽  
pp. 3312-3317 ◽  
Author(s):  
K. Nagao ◽  
F. Ginhoux ◽  
W. W. Leitner ◽  
S.-I. Motegi ◽  
C. L. Bennett ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Epidermal Langerhans Cells

Langerhans Cell Histiocytosis: Back to Histiocytosis X

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. SCI-8-SCI-8
Author(s):  
Carl E. Allen
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Conflicts Of Interest ◽  
Langerhans Cell ◽  
Histiocytosis X ◽  
Specific Gene ◽  
Myeloid Dendritic Cell ◽  
Epidermal Langerhans Cells

Abstract Abstract SCI-8 Langerhans cell histiocytosis (LCH) is a disorder characterized by inflammatory lesions that include pathologic CD207+ dendritic cells. LCH has pleotropic clinical presentations ranging from single lesions cured by curettage to potentially fatal multisystem disease. The first descriptions of LCH, including Hand-Schüller-Christian disease and Letterer-Siwe disease, were based on anatomic location and extent of the lesions. Despite clinical heterogeneity, LCH lesions are generally indistinguishable by histology, which led to the notion that the spectrum of clinical manifestations represents a single disorder, histiocytosis X. The designation “Langerhans cell histiocytosis” was subsequently proposed with discovery of cytoplasmic Birbeck granules in the pathologic infiltrating dendritic cells in histiocytosis X lesions, a feature shared by epidermal Langerhans cells. The etiology of LCH remains elusive, and debate of LCH as an inflammatory versus malignant disorder remains unresolved. However, recent discoveries question the model of LCH arising from transformed or pathologically activated epidermal Langerhans cells. We found cell-specific gene expression signature in CD207+ dendritic cells within LCH lesions to be more consistent with immature myeloid dendritic cell precursors than epidermal Langerhans cells. Furthermore, recent mouse studies demonstrate that CD207+ is more promiscuous than previously appreciated. Langerin (CD207) expression can be induced in many dendritic cell lineages, supporting the plausibility of a spectrum of candidates for an LCH cell of origin, including circulating dendritic cell precursors. Finally, recurrent activating BRAF mutations in LCH lesions suggest a role for a hyperactive RAS pathway in LCH pathogenesis, and possibly in normal dendritic cell development. This presentation will discuss the historical background and recent advances in LCH biology, along with a proposal to reframe “histiocytosis X” as a myeloid neoplasia caused by aberrant maturation and migration of myeloid dendritic cell precursors. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

Immunity ◽  
2008 ◽  
Vol 29 (3) ◽  
pp. 497-510 ◽  
Author(s):  
Eynav Klechevsky ◽  
Rimpei Morita ◽  
Maochang Liu ◽  
Yanying Cao ◽  
Sebastien Coquery ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Epidermal Langerhans Cells

scholarly journals Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state

2007 ◽  
Vol 204 (13) ◽  
pp. 3133-3146 ◽  
Author(s):  
Florent Ginhoux ◽  
Matthew P. Collin ◽  
Milena Bogunovic ◽  
Michal Abel ◽  
Marylene Leboeuf ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Steady State ◽  
Langerhans Cells ◽  
Current View ◽  
Lectin Receptor ◽  
Bone Marrow Chimeras ◽  
Human And Mouse ◽  
Draining Lymph Nodes ◽  
Epidermal Langerhans Cells

Langerin is a C-type lectin receptor that recognizes glycosylated patterns on pathogens. Langerin is used to identify human and mouse epidermal Langerhans cells (LCs), as well as migratory LCs in the dermis and the skin draining lymph nodes (DLNs). Using a mouse model that allows conditional ablation of langerin+ cells in vivo, together with congenic bone marrow chimeras and parabiotic mice as tools to differentiate LC- and blood-derived dendritic cells (DCs), we have revisited the origin of langerin+ DCs in the skin DLNs. Our results show that in contrast to the current view, langerin+CD8− DCs in the skin DLNs do not derive exclusively from migratory LCs, but also include blood-borne langerin+ DCs that transit through the dermis before reaching the DLN. The recruitment of circulating langerin+ DCs to the skin is dependent on endothelial selectins and CCR2, whereas their recruitment to the skin DLNs requires CCR7 and is independent of CD62L. We also show that circulating langerin+ DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens. We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies.

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