DNA MICROARRAY-BASED ECOTOXICOLOGICAL BIOMARKER DISCOVERY IN A SMALL FISH MODEL SPECIES

2008 ◽  
Vol 27 (3) ◽  
pp. 664 ◽  
Author(s):  
Rong-Lin Wang ◽  
David Bencic ◽  
Adam Biales ◽  
David Lattier ◽  
Mitch Kostich ◽  
...  
Keyword(s):  
Dna Microarray ◽  
Biomarker Discovery ◽  
Small Fish ◽  
Model Species ◽  
Fish Model

DNA MICROARRAY-BASED ECOTOXICOLOGICAL BIOMARKER DISCOVERY IN A SMALL FISH MODEL SPECIES

2007 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Rong-Lin Wang ◽  
David Bencic ◽  
Adam Biales ◽  
David Lattier ◽  
Mitch Kostich ◽  
...  
Keyword(s):  
Dna Microarray ◽  
Biomarker Discovery ◽  
Small Fish ◽  
Model Species ◽  
Fish Model

scholarly journals Site fidelity and localised homing behaviour in three-spined sticklebacks (Gasterosteus aculeatus)

Behaviour ◽  
2013 ◽  
Vol 150 (14) ◽  
pp. 1689-1708 ◽  
Author(s):  
A.J.W. Ward ◽  
R. James ◽  
A.D.M. Wilson ◽  
M.M. Webster
Keyword(s):  
Social Facilitation ◽  
Site Fidelity ◽  
Gasterosteus Aculeatus ◽  
Home Ranges ◽  
Small Fish ◽  
Behavioural Ecology ◽  
Model Species ◽  
Homing Behaviour ◽  
Capture Site

The ability of animals to disperse towards their original home range following displacement has been demonstrated in a number of species. However, little is known about the homing ability of three-spine sticklebacks (Gasterosteus aculeatus), an important model species in behavioural ecology. In addition, few studies have examined the role of social facilitation in relation to homing behaviour in fishes. We examined homing behaviour of sticklebacks displaced over distances of between 80 m and 160 m in land-drains with directional water flow. Fish were translocated from their original capture site, tagged and then released either in groups or solitarily. We performed recapture transects either one or two days later. Data provided by recaptured sticklebacks show that the fish dispersed in the direction of their original capture site. Although fish translocated downstream typically moved further than those translocated upstream, both dispersed towards their original capture site. There was no difference between fish released solitarily or in groups in their homing ability and indeed there was little evidence that fish translocated in groups remained together following their release. The homing ability of the fish was demonstrated by the finding that up to 80% of fish returned to their home ranges within two days of release over a distance equivalent to approximately 5000 body lengths of these small fish.

scholarly journals p53 Regulates Homeostasis in Irradiation-Injured Tissue in the Developing Brain and Mature Testis in the Small-Fish Model, Medaka (Oryzias latipes)

2019 ◽  
Author(s):  
Takako Yasuda
Keyword(s):  
Oryzias Latipes ◽  
Developing Brain ◽  
Genome Integrity ◽  
Small Fish ◽  
Fish Model ◽  
Cycle Arrest ◽  
Structural Abnormalities ◽  
Vertebrate Model ◽  
Induction Of Apoptosis ◽  
Apoptotic Induction

The tumor suppressor protein p53 is considered a guardian of genome integrity, regulating the induction of apoptosis and cell cycle arrest in response to irradiation to block the transmission of teratogenic mutations to progeny cells. We examined the function of p53 in highly radiosensitive tissues, the developing brain and mature testis, using a small fish model, medaka (Oryzias latipes). Medaka offer advantages as a vertebrate model system, as the transparency and small size of the embryos enables clear detection of apoptotic cells in the developing brain. In addition, the simple architecture of medaka testes enables more precise identification of the differentiating spermatogenic stages compared with mammals. We found that in irradiated p53-deficient embryonic brain, diminished induction of apoptosis facilitated tissue regeneration earlier compared to irradiated wild-type embryos, which remained structural abnormalities in the retina at hatching. Moreover, the prominent delay in apoptotic induction in irradiated p53-deficient testes could induce transient mis-differentiation during spermatogenesis, such as the formation of ovum-like cells (testis-ova). However, all testis-ova cells were eliminated via p53-independent apoptosis, and spermatogenesis was completely restored within 1 month after irradiation. Collectively, these data indicate that p53 is not indispensable for the restoration of irradiation-induced damaged tissues.

DNA MICROARRAY APPLICATION IN ECOTOXICOLOGY: EXPERIMENTAL DESIGN, MICROARRAY SCANNING, AND FACTORS IMPACTING TRANSCRIPTIONAL PROFILES IN A SMALL FISH SPECIES

2007 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Rong-Lin Wang ◽  
Adam Biales ◽  
David Bencic ◽  
David Lattier ◽  
Mitch Kostich ◽  
...  
Keyword(s):  
Experimental Design ◽  
Dna Microarray ◽  
Fish Species ◽  
Small Fish ◽  
Transcriptional Profiles

A small fish model for quantitative analysis of radiation effects using visualized thymus responses in GFP transgenic medaka

2019 ◽  
Vol 95 (8) ◽  
pp. 1144-1149 ◽  
Author(s):  
Kouichi Maruyama ◽  
Norimasa Iwanami ◽  
Takako Maruyama-Hayakawa ◽  
Kazutaka Doi ◽  
Bing Wang
Keyword(s):  
Quantitative Analysis ◽  
Radiation Effects ◽  
Small Fish ◽  
Fish Model

scholarly journals In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

2012 ◽  
Vol 40 (10) ◽  
pp. 4653-4665 ◽  
Author(s):  
Brian Dall Schyth ◽  
Jesper Bertram Bramsen ◽  
Malgorzata Maria Pakula ◽  
Sekar Larashati ◽  
Jørgen Kjems ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Small Fish ◽  
In Vivo Screening ◽  
Fish Model

scholarly journals Use of chemical mixtures to differentiate mechanisms of endocrine action in a small fish model

2010 ◽  
Vol 99 (3) ◽  
pp. 389-396 ◽  
Author(s):  
Gerald T. Ankley ◽  
Kathleen M. Jensen ◽  
Michael D. Kahl ◽  
Elizabeth J. Durhan ◽  
Elizabeth A. Makynen ◽  
...  
Keyword(s):  
Small Fish ◽  
Chemical Mixtures ◽  
Fish Model
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