scholarly journals Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin?

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Sarah Long
Keyword(s):  
Open Access ◽  
Study Design ◽  
Clinical Signs ◽  
Positive Control ◽  
Comparable Efficacy ◽  
Regulatory Body ◽  
Bottom Line ◽  
Routes Of Administration ◽  
The Uk ◽  
Generalised Demodicosis

<p><strong>PICO question</strong></p><p>In dogs with generalised demodicosis, are isoxazolines as effective as a combined formulation of imidacloprid and moxidectin at reducing mite count and the severity of associated clinical signs?</p><p><strong>Clinical bottom line</strong></p><p>Five single-blinded, randomised, positive control trials, most under laboratory conditions, directly compared the use of isoxazolines against moxidectin/imidacloprid to treat canine generalised demodicosis. All of them showed comparable efficacy of isoxazolines. Three different isoxazolines were studied with two routes of administration (oral and topical) and four different dosing frequencies of moxidectin/imidacloprid. This made the papers more challenging to compare however, the evidence provided is sufficient to support their use. All of these trials were sponsored by the manufacturers of their respective isoxazoline products which may bias the study design and reporting of results. It is worth noting that sarolaner (Simparica™, Zoetis UK) was licensed in the UK for the treatment of canine demodicosis in January 2018 and that in the UK the Cascade should be followed when prescribing treatments. The licensed use of isoxazolines in other countries is beyond the scope of this article and the reader is urged to check local regulatory body advice before prescribing the below medications.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Is Topical or Systemic Antimicrobial Therapy More Effective for the Treatment of Feline Acne With Secondary Bacterial Infection?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Wendy Kwok ◽  
Kate Charlotte Mellor
Keyword(s):  
Open Access ◽  
Bacterial Infection ◽  
Antimicrobial Therapy ◽  
Systemic Treatment ◽  
Clinical Signs ◽  
Sufficient Evidence ◽  
Bottom Line ◽  
Secondary Bacterial Infection

<strong>PICO question</strong><br /><p>In cats with feline acne and secondary bacterial folliculitis or furunculosis, is topical or systemic antimicrobial therapy superior for reducing time to resolution and severity of clinical signs?</p><strong>Clinical bottom line</strong><br /><p>There is no sufficient evidence to compare topical versus systemic treatment in feline acne with secondary folliculitis/furunculosis.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals In an Adult Horse With Severe Asthma (Previously Recurrent Airway Obstruction) Does Using Inhaled Corticosteroids Result in an Equal Improvement in Clinical Signs When Compared to Systemic Corticosteroids?

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Natasha A Jocelyn
Keyword(s):  
Open Access ◽  
Airway Obstruction ◽  
Severe Asthma ◽  
Inhaled Corticosteroids ◽  
Clinical Signs ◽  
The Body ◽  
Recurrent Airway Obstruction ◽  
Bottom Line ◽  
Systemic Corticosteroids ◽  
Equine Asthma

<strong>PICO question</strong><br /><p>In an adult horse with severe asthma (previously recurrent airway obstruction (RAO)) does using inhaled corticosteroids result in an equal improvement in clinical signs when compared to systemic corticosteroids?</p><strong>Clinical bottom line</strong><br /><p>The level of confidence in the outcomes from the body of evidence in the 4 papers identified is high. This suggests inhaled corticosteroids (fluticasone and beclomethasone) when used at an appropriate dose can have equivalent effects on severe equine asthma as systemic intravenous dexamethasone. Inhaled corticosteroids can take longer to have the desired effects. </p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Can Iodine-restricted Diets Normalise Serum Total Thyroxine (TT4) and Subsequently Improve Clinical Signs in Cats With Hyperthyroidism?

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Oliver Gilman
Keyword(s):  
Open Access ◽  
Clinical Signs ◽  
Normal Diet ◽  
Compelling Evidence ◽  
Restricted Diet ◽  
Bottom Line ◽  
Total Thyroxine

<strong>PICO question</strong><br /><p>In cats with hyperthyroidism, does an iodine-restricted diet normalise the serum TT4 (total thyroxine) levels and reduce the severity of the clinical signs when compared to cats on a normal diet?</p><strong>Clinical bottom line</strong><br /><p>Whilst there is some evidence that iodine-restricted diets can help to renormalise serum TT4 in cats with hyperthyroidism, this is not always effective and there is a lack of compelling evidence to suggest this is associated with a resolution of clinical signs in the long-term.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Does Adding Transdermal Nitroglycerine to Other Therapies Used for Management of Left-sided Congestive Heart Failure in Dogs Speed the Resolution of Clinical Signs?

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Jenefer R Stillion ◽  
Søren R Boysen
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Open Access ◽  
Experimental Evidence ◽  
Clinical Signs ◽  
Evidence Based ◽  
Bottom Line

<p><strong><strong>There is an erratum to this paper published in <em>Veterinary Evidence</em> Vol 3, Issue 1 (2018): <a id="pub-id::doi" href="/index.php/ve/article/view/168/220" target="_blank">http://dx.doi.org/10.18849/ve.v3i1.168</a></strong></strong></p><p><strong>Clinical bottom line</strong></p><p>There is very weak veterinary clinical and experimental evidence based upon a limited number of studies to indicate that adding transdermal nitroglycerine to other therapies used for management of left-sided congestive heart failure in dogs speeds the resolution of clinical signs.</p><p> </p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Is There Any Evidence to Support the Use of Garlic as a Wormer for Dogs and Cats in the UK?

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Louise Buckley
Keyword(s):  
Open Access ◽  
Oral Administration ◽  
Worm Burden ◽  
Outcome Measure ◽  
Single Species ◽  
Bottom Line ◽  
Intestinal Worm ◽  
The Uk

<strong>PICO question</strong><br /><p>In dogs and cats, is the oral administration of garlic, compared to no treatment, efficacious at preventing or reducing the intestinal worm burden (species found in the UK)?</p><strong>Clinical bottom line</strong><br /><p>No studies were identified that investigated the efficacy of garlic at preventing intestinal worm burden. Garlic reduced egg and/or larvae counts in the worm species studied. However, where measured, egg and larvae count rapidly (2 days) returned to pretreatment levels once dietary garlic was discontinued. None of the studies included adulticidal action as an outcome measure. In the absence of research to demonstrate high levels of adulticidal action against a range of intestinal wormers at therapeutic, non-toxic levels in cats and dogs, clients should be advised that garlic has not been demonstrated to be an effective anthelmintic (either for multiple or single species use) for use in dogs and cats either to prevent or to treat an intestinal worm burden.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Treatment Duration With Steroid Monotherapy in Dogs With Steroid Responsive Meningitis-Arteritis

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Richard William Lawn
Keyword(s):  
Open Access ◽  
Clinical Remission ◽  
Treatment Duration ◽  
Time Course ◽  
Clinical Signs ◽  
Steroid Treatment ◽  
Post Treatment ◽  
Bottom Line ◽  
Clinical Resolution ◽  
Disease Free

<strong>PICO question</strong><br /><p>In dogs suspected of having steroid responsive meningitis-arteritis (SRMA), how long should immunosuppressive monotherapy with steroids be undertaken in order to achieve clinical resolution without relapse of clinical signs?</p><strong>Clinical bottom line</strong><br /><p>Based on the currently available literature, steroid treatment using the protocol outlined in Lowrie et al. (2009) at a gradually tapering dose over a course of 6 months, appeared to lead to clinical remission in all cases, with a disease free post treatment interval of at least 6 months. However, further research is needed as there are currently three published papers with a low number of cases, so a definitive time course cannot be suggested until stronger evidence is available.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

ATTITUDE TO OPEN ACCESS IN RUSSIAN SCHOLARLY COMMUNITY: 2018. SURVEY RESULTS AND ANALYSIS

2018 ◽  
Vol 1 (1) ◽  
pp. 6-21 ◽  
Author(s):  
I. K. Razumova ◽  
N. N. Litvinova ◽  
M. E. Shvartsman ◽  
A. Yu. Kuznetsov
Keyword(s):  
Open Access ◽  
Open Access Publishing ◽  
Scholarly Community ◽  
Research Areas ◽  
Survey Results ◽  
The Difference ◽  
Policies And Programs ◽  
The Uk ◽  
High Level ◽  
Access Policies

Introduction. The paper presents survey results on the awareness towards and practice of Open Access scholarly publishing among Russian academics.Materials and Methods. We employed methods of statistical analysis of survey results. Materials comprise results of data processing of Russian survey conducted in 2018 and published results of the latest international surveys. The survey comprised 1383 respondents from 182 organizations. We performed comparative studies of the responses from academics and research institutions as well as different research areas. The study compares results obtained in Russia with the recently published results of surveys conducted in the United Kingdom and Europe.Results. Our findings show that 95% of Russian respondents support open access, 94% agree to post their publications in open repositories and 75% have experience in open access publishing. We did not find any difference in the awareness and attitude towards open access among seven reference groups. Our analysis revealed the difference in the structure of open access publications of the authors from universities and research institutes. Discussion andConclusions. Results reveal a high level of awareness and support to open access and succeful practice in the open access publications in the Russian scholarly community. The results for Russia demonstrate close similarity with the results of the UK academics. The governmental open access policies and programs would foster the practical realization of the open access in Russia.

Editorial: Antisemitism in the UK Labour Party

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Lesley Klaff
Keyword(s):  
Open Access ◽  
Public Sphere ◽  
Labour Party ◽  
Research Note ◽  
The Public ◽  
The Public Sphere ◽  
The Uk ◽  
Exciting Development

I am pleased to publish an open-access online preprint of two articles and a research note that will appear in the forthcoming issue of the Journal of Contemporary Antisemitism 3, no. 2 (Fall 2020). This preprint is a new and exciting development for the Journal. It has been made possible by the generous donations from sponsors, including BICOM's co-chairman, David Cohen, whose support for the work of the Journal allows for timely scholarly analysis to be put into the public sphere.

scholarly journals European Youth Work Policy and Young People’s Experience of Open Access Youth Work

2021 ◽  
pp. 1-21
Author(s):  
JON ORD ◽  
MARC CARLETTI ◽  
DANIELE MORCIANO ◽  
LASSE SIURALA ◽  
CHRISTOPHE DANSAC ◽  
...  
Keyword(s):  
Open Access ◽  
Young People ◽  
Positive Impact ◽  
Policy Formulation ◽  
Youth Work ◽  
Policy Makers ◽  
Policy Goals ◽  
The Uk ◽  
The Impact ◽  
European Youth

Abstract This article examines young people’s experiences of open access youth work in settings in the UK, Finland, Estonia, Italy and France. It analyses 844 individual narratives from young people, which communicate the impact of youthwork on their lives. These accounts are then analysed in the light of the European youth work policy goals. It concludes that it is encouraging that what young people identify as the positive impact of youth work are broadly consistent with many of these goals. There are however some disparities which require attention. These include the importance young people place on the social context of youth work, such as friendship, which is largely absent in EU youth work policy; as well as the importance placed on experiential learning. The paper also highlights a tension between ‘top down’ policy formulation and the ‘youth centric’ practices of youth work. It concludes with a reminder to policy makers that for youth work to remain successful the spaces and places for young people must remain meaningful to them ‘on their terms’.

024 Quiescent Wakefulness: Characterising the Impact of Oxytocin on Sleep-Wake Behaviour in Male and Female Rats

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A11-A11
Author(s):  
Joel Raymond ◽  
Nicholas Everett ◽  
Anand Gururajan ◽  
Michael Bowen
Keyword(s):  
Rem Sleep ◽  
Sleep Onset ◽  
Conscious State ◽  
Positive Control ◽  
Female Rats ◽  
Male And Female ◽  
Routes Of Administration ◽  
Male And Female Rats ◽  
Competing Hypotheses ◽  
The Impact

Abstract Introduction Oxytocin is a versatile hypothalamic neuropeptide involved in diverse neurobehavioural processes. Since oxytocin can elicit anxiolytic and serenic effects, one could hypothesise that oxytocin should prime the brain for sleep and promote hypnogenesis. However, based on the social salience hypothesis—that oxytocin promotes prosocial behaviour and directs attention toward social stimuli—one could also posit that oxytocin should promote wakefulness. At present, little research has comprehensively characterised the effect of oxytocin on sleep-wake behaviour and no explanation to reconcile these two seemingly competing hypotheses has been proposed. Methods This study investigated the effects of oxytocin on sleep-wake outcomes using radiotelemetry-based polysomnography in adult male and female Wistar rats. Oxytocin was administered via the intraperitoneal (IP; 0.1, 0.3 and 1 mg/kg) and intranasal (IN; 0.06, 1, 3 mg/kg) routes. Caffeine (IP and IN; 10 mg/kg) was also administered as a wake-promoting positive control. Additionally, pre-treatment with the oxytocin receptor (OTR) antagonist L-368,899 (IP; 5 mg/kg) and vasopressin 1a receptor (V1aR) antagonist SR49059 (IP; 1 mg/kg) followed by oxytocin (IP; 1 mg/kg) was conducted to determine which receptor(s) mediated sleep-wake effects of oxytocin. Results In both male and female rats, IP oxytocin produced dose-dependent effects on sleep-wake behaviour. Specifically, oxytocin initially promoted quiescent wakefulness (a restful but conscious state) at the cost of reducing both active wakefulness and sleep. Throughout the 1.5-hour period post-administration, oxytocin delayed REM sleep onset and reduced the proportion of both NREM and REM sleep. Conversely, IN oxytocin did not significantly alter any sleep-wake parameters at any dose tested. Caffeine demonstrated wake-promoting effects under both the IP and IN routes of administration. The involvement of OTR and V1aR binding in oxytocin-induced effects on sleep-wake outcomes will be discussed. Conclusion These findings appear to reconcile the two competing hypotheses: in rats, IP oxytocin appears to promote a state of quiescent wakefulness—one of calm and rest, but also of conscious responsivity to environmental stimuli. IN oxytocin demonstrated little to no effect on sleep-wake behaviour, which is a crucial finding given the escalating use of IN oxytocin as a therapeutic for conditions with comorbid disordered sleep. Support (if any) None.

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