scholarly journals THE SOLANUM TUBEROSUM KNOWLEDGE BASE: THE SECTION ON MOLECULAR-GENETIC REGULATION OF METABOLIC PATHWAYS

2018 ◽  
Vol 22 (1) ◽  
pp. 8-17 ◽  
Author(s):  
T. V. Ivanisenko ◽  
O. V. Saik ◽  
P. S. Demenkov ◽  
V. K. Khlestkin ◽  
E. K. Khlestkina ◽  
...  
Keyword(s):  
Solanum Tuberosum ◽  
Knowledge Base ◽  
Metabolic Pathways ◽  
Molecular Genetic ◽  
Genetic Regulation

scholarly journals Prioritization of potato genes involved in the formation of agronomically valuable traits using the SOLANUM TUBEROSUM knowledge base

2019 ◽  
Vol 23 (3) ◽  
pp. 312-319
Author(s):  
P. S. Demenkov ◽  
O. V. Saik ◽  
T. V. Ivanisenko ◽  
N. A. Kolchanov ◽  
A. V. Kochetov ◽  
...  
Keyword(s):  
Solanum Tuberosum ◽  
Knowledge Base ◽  
Candidate Genes ◽  
Genetic Relationships ◽  
Molecular Genetic ◽  
Biological Data ◽  
Targeted Mutagenesis ◽  
Pubmed Database ◽  
Genetic Mechanisms ◽  
Selection Of

The development of highly efficient technologies in genomics, transcriptomics, proteomics and metabolomics, as well as new technologies in agriculture has led to an “information explosion” in plant biology and crop production, including potato production. Only a small part of the information reaches formalized databases (for example, Uniprot, NCBI Gene, BioGRID, IntAct, etc.). One of the main sources of reliable biological data is the scientific literature. The well-known PubMed database contains more than 18 thousand abstracts of articles on potato. The effective use of knowledge presented in such a number of non-formalized documents in natural language requires the use of modern intellectual methods of analysis. However, in the literature, there is no evidence of a widespread use of intelligent methods for automatically extracting knowledge from scientific publications on cultures such as potatoes. Earlier we developed the SOLANUM TUBEROSUM knowledge base (http://www-bionet.sysbio.cytogen. ru/and/plant/). Integrated into the knowledge base information about the molecular genetic mechanisms underlying the selection of significant traits helps to accelerate the identification of candidate genes for the breeding characteristics of potatoes and the development of diagnostic markers for breeding. The article searches for new potential participants of the molecular genetic mechanisms of resistance to adverse factors in plants. Prioritizing candidate genes has shown that the PHYA, GF14, CNIH1, RCI1A, ABI5, CPK1, RGS1, NHL3, GRF8, and CYP21-4 genes are the most promising for further testing of their relationships with resistance to adverse factors. As a result of the analysis, it was shown that the molecular genetic relationships responsible for the formation of significant agricultural traits are complex and include many direct and indirect interactions. The construction of associative gene networks and their analysis using the SOLANUM TUBEROSUM knowledge base is the basis for searching for target genes for targeted mutagenesis and marker-oriented selection of potato varieties with valuable agricultural characteristics.

scholarly journals Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma

2004 ◽  
Vol 18 (5) ◽  
pp. 705-709 ◽  
Author(s):  
Lin Lin ◽  
David Hicks ◽  
Bo Xu ◽  
Jessica E Sigel ◽  
Wilma F Bergfeld ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Expression Profile ◽  
Molecular Genetic ◽  
Epithelioid Sarcoma ◽  
Genetic Regulation

scholarly journals Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure

2020 ◽  
Vol 25 (10) ◽  
pp. 3933
Author(s):  
T. B. Pecherina ◽  
A. G. Kutikhin
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Targeted Therapy ◽  
Myocardial Fibrosis ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Controversial Subject ◽  
Patients With Heart Failure ◽  
Histological Confirmation ◽  
The Relationship

Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.

scholarly journals Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

2016 ◽  
Vol 30 (1) ◽  
pp. 77-91 ◽  
Author(s):  
Ryan K. Mitchell ◽  
Ming Hu ◽  
Pauline L. Chabosseau ◽  
Matthew C. Cane ◽  
Gargi Meur ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Positive Association

scholarly journals Retrospective Survey on the Outcome of 36 Diverse Cases of Anemia

2020 ◽  
Vol 1 (1) ◽  
pp. 01-07
Author(s):  
George Zhu
Keyword(s):  
Complete Remission ◽  
Megaloblastic Anemia ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Deficiency Anemia ◽  
Comprehensive Treatment ◽  
Malignant Tumours ◽  
Drug Adsorption ◽  
Immune Hemolytic Anemia

Anemia is clinical common event. In this study,a retrospective study of 36 different types of anemias was place in proper interpretative review for their therapeutical outcome. By using comprehensive treatment regimen according to patients’ condition, 23 patients obtained cure or complete remission (CR), with the exception of refractory cancers and uremic anemia. Iron supplement was provided in 5 iron deficiency anemia. One megaloblastic anemia required the prescription of the supplement of vitamin B12 or folate deficiency. 2 aplastic anemia obtained complete remission with the integrated protocol of methyltestosterone,adenine,leucogen,and levamisol. Steroid hormone (e.g. prednisone) mixed traditional medicine were occasionally promising benefit in a nephrotic syndrome and renal insufficiency. Among 2 cases with dug- induced immune hemolytic anemia (DIIHA), laboratory studies a patient's serum contained paracetamol -dependent antibody that in the presence of paracetamol, agglutinated in vitro with "O" red cells with or without complement. Drug antibody titer was 1:4 positive. The reactive mechanism was attributed to both immune complex type and drug-adsorption, whereas another herba origanum vulgare- induced hemolysis secondary to drug adsorption only. In addition, regarding anemia caused by malignant tumours, the molecular genetic regulation of retinoic acid in acute promyelocytic leukemia (APL) has been further illustrated(see figure in full text). Therefore,to strengthen the active prevention and/or early interceptive treatment of anemia is our care.

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