scholarly journals Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma

2004 ◽  
Vol 18 (5) ◽  
pp. 705-709 ◽  
Author(s):  
Lin Lin ◽  
David Hicks ◽  
Bo Xu ◽  
Jessica E Sigel ◽  
Wilma F Bergfeld ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Expression Profile ◽  
Molecular Genetic ◽  
Epithelioid Sarcoma ◽  
Genetic Regulation

Molecular genetic alterations and gene expression profile of a malignant rhabdoid tumor of the kidney

2005 ◽  
Vol 163 (2) ◽  
pp. 130-137 ◽  
Author(s):  
Toshihito Nagata ◽  
Yasuo Takahashi ◽  
Yukimoto Ishii ◽  
Satoshi Asai ◽  
Megumi Sugahara-Kobayashi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Molecular Genetic ◽  
Genetic Alterations ◽  
Rhabdoid Tumor ◽  
Malignant Rhabdoid Tumor

scholarly journals microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma

Blood ◽  
2010 ◽  
Vol 115 (13) ◽  
pp. 2630-2639 ◽  
Author(s):  
Jian-Jun Zhao ◽  
Jianhong Lin ◽  
Tint Lwin ◽  
Hua Yang ◽  
Jianping Guo ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Prognostic Marker ◽  
Expression Profile ◽  
Mirna Expression ◽  
Cell Lymphoma ◽  
Mrna Levels ◽  
Expression Signature ◽  
Mantle Cell ◽  
Pathogenetic Factor

Abstract Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although several protein-coding genes are altered, expression signature and importance of microRNA (miRNA) have not been well documented in this malignancy. Here, we performed miRNA expression profile in 30 patients with MCL using a platform containing 515 human miRNAs. Eighteen miRNAs were down-regulated and 21 were up-regulated in MCL compared with normal B lymphocytes. The most frequently altered miRNAs are decrease of miR-29a/b/c, miR-142-3p/5p, and miR-150 and increase of miR-124a and miR-155. Notably, expression levels of miR-29 family are associated with prognosis. The patients with significant down-regulated miR-29 had short survival compared with those who express relatively high levels of miR-29. The prognostic value of miR-29 is comparable with the Mantle Cell Lymphoma International Prognostic Index. Furthermore, we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3′-untranslated region. Inverse correlation between miR-29 and CDK6 was observed in MCL. Because cyclin D1 overexpression is a primary event and exerts its function through activation of CDK4/CDK6, our results in primary MCL cells indicate that down-regulation of miR-29 could cooperate with cyclin D1 in MCL pathogenesis. Thus, our findings provide not only miRNA expression signature but also a novel prognostic marker and pathogenetic factor for this malignancy.

scholarly journals Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure

2020 ◽  
Vol 25 (10) ◽  
pp. 3933
Author(s):  
T. B. Pecherina ◽  
A. G. Kutikhin
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Targeted Therapy ◽  
Myocardial Fibrosis ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Controversial Subject ◽  
Patients With Heart Failure ◽  
Histological Confirmation ◽  
The Relationship

Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.

scholarly journals Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

2016 ◽  
Vol 30 (1) ◽  
pp. 77-91 ◽  
Author(s):  
Ryan K. Mitchell ◽  
Ming Hu ◽  
Pauline L. Chabosseau ◽  
Matthew C. Cane ◽  
Gargi Meur ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Positive Association

scholarly journals Comparative Analysis of Long Non-Coding RNA and mRNA Expression Provides Insights into Adaptation to Hypoxia in Tibetan Sheep

2020 ◽  
Author(s):  
Jianbin Liu ◽  
Chao Yuan ◽  
Zengkui Lu ◽  
Deqing Zhuoga ◽  
Tingting Guo ◽  
...  
Keyword(s):  
High Altitude ◽  
Expression Profile ◽  
Transcriptome Analysis ◽  
Target Genes ◽  
Genetic Regulation ◽  
Comparative Transcriptome ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia ◽  
Tibetan Sheep ◽  
Hu Sheep

Abstract Background: Tibetan sheep have lived on the Tibetan Plateau for thousands of years and they have a good adaptability to the hypoxic environment and strong disease resistance. However, the molecular mechanism of the Tibetan sheep adapting to this extreme environment, especially the role of genetic regulation is still unknown. Emerging evidence suggests that long non-coding RNAs (lncRNAs) participate in the regulation of a diverse range of biological processes. To explore the potential lncRNAs involved in Tibetan sheep adapting to high altitude hypoxia environment, we analyzed the expression profile of lncRNAs and mRNAs in liver and lung tissue of sheep based on the comparative transcriptome analysis between four Tibetan sheep populations (high altitude) and Hu sheep (low altitude). Results: A total of 7848 differentially expressed (DE) lncRNAs transcripts and 22971 DE mRNAs transcripts were detected by pairwise comparison. The expression patterns of selected mRNAs and lncRNAs were validated by qRT-PCR and the results correlated well with the transcriptome data. Moreover, the functional annotation analysis based on the Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) databases showed that DE mRNAs and the target genes of the lncRNAs were significantly enriched in organ morphogenesis, response to stimulus, heme binding, immune system, arginine and proline metabolism, and fatty acid biosynthesis. The prediction of mRNA-mRNA and lncRNA-mRNA interaction networks further revealed transcripts potentially involved in adaptation to high altitude hypoxia, the hub genes that DDX24, PDCD11, EIF4A3, NDUFA11, SART1, PRPF8 and TCONS_00306477, TCONS_00306029, TCONS_00139593, TCONS_00293272, TCONS_00313398 were selected. Additionally, a set of target genes, PIK3R1, IGF1R, FZD6, IFNB2, ATF3, MB, CYP2B4, PSMD13, and TGFB1 were also identified as candidate genes associated with high altitude hypoxia adaptation. Conclusions: A collection of aberrantly expressed lncRNA, a set of target genes and biological pathways known to be relevant for altitude adaptation were identified by comparative transcriptome analysis between Tibetan sheep and Hu sheep. Our results first identified the characterization and expression profile of lncRNAs between Tibetan sheep and Hu sheep and provides insights into the genetic regulation mechanisms for Tibetan sheep adaptation to high altitude hypoxia environments.

scholarly journals Retrospective Survey on the Outcome of 36 Diverse Cases of Anemia

2020 ◽  
Vol 1 (1) ◽  
pp. 01-07
Author(s):  
George Zhu
Keyword(s):  
Complete Remission ◽  
Megaloblastic Anemia ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Deficiency Anemia ◽  
Comprehensive Treatment ◽  
Malignant Tumours ◽  
Drug Adsorption ◽  
Immune Hemolytic Anemia

Anemia is clinical common event. In this study,a retrospective study of 36 different types of anemias was place in proper interpretative review for their therapeutical outcome. By using comprehensive treatment regimen according to patients’ condition, 23 patients obtained cure or complete remission (CR), with the exception of refractory cancers and uremic anemia. Iron supplement was provided in 5 iron deficiency anemia. One megaloblastic anemia required the prescription of the supplement of vitamin B12 or folate deficiency. 2 aplastic anemia obtained complete remission with the integrated protocol of methyltestosterone,adenine,leucogen,and levamisol. Steroid hormone (e.g. prednisone) mixed traditional medicine were occasionally promising benefit in a nephrotic syndrome and renal insufficiency. Among 2 cases with dug- induced immune hemolytic anemia (DIIHA), laboratory studies a patient's serum contained paracetamol -dependent antibody that in the presence of paracetamol, agglutinated in vitro with "O" red cells with or without complement. Drug antibody titer was 1:4 positive. The reactive mechanism was attributed to both immune complex type and drug-adsorption, whereas another herba origanum vulgare- induced hemolysis secondary to drug adsorption only. In addition, regarding anemia caused by malignant tumours, the molecular genetic regulation of retinoic acid in acute promyelocytic leukemia (APL) has been further illustrated(see figure in full text). Therefore,to strengthen the active prevention and/or early interceptive treatment of anemia is our care.

scholarly journals Comparative Analysis of Long Non-Coding RNA and mRNA Expression Provides Insights Into Adaptation to Hypoxia in Tibetan Sheep

2021 ◽  
Author(s):  
Fan Wang ◽  
Jianbin Liu ◽  
Qiaoying Zeng ◽  
Deqing Zhuoga
Keyword(s):  
High Altitude ◽  
Expression Profile ◽  
Transcriptome Analysis ◽  
Target Genes ◽  
Genetic Regulation ◽  
Comparative Transcriptome ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia ◽  
Tibetan Sheep ◽  
Hu Sheep

Abstract Tibetan sheep have lived on the Qinghai-Tibetan Plateau for thousands of years and they have a good adaptability to the hypoxic environment and strong disease resistance. However, the molecular mechanism of the Tibetan sheep adapting to this extreme environment, especially the role of genetic regulation is still unknown. Emerging evidence suggests that long non-coding RNAs (lncRNAs) participate in the regulation of a diverse range of biological processes. To explore the potential lncRNAs involved in Tibetan sheep adapting to high altitude hypoxia environment, we analyzed the expression profile of lncRNAs and mRNAs in liver and lung tissue of sheep based on the comparative transcriptome analysis between four Tibetan sheep populations (high altitude) and Hu sheep (low altitude). The results showed a total of 7848 differentially expressed (DE) lncRNAs transcripts and 22971 DE mRNAs transcripts were detected by pairwise comparison. The expression patterns of selected mRNAs and lncRNAs were validated by qRT-PCR and the results correlated well with the transcriptome data. Moreover, the functional annotation analysis based on the Gene Ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) databases showed that DE mRNAs and the target genes of the lncRNAs were significantly enriched in organ morphogenesis, response to stimulus, heme binding, immune system, arginine and proline metabolism, and fatty acid biosynthesis. The prediction of mRNA-mRNA and lncRNA-mRNA interaction networks further revealed transcripts potentially involved in adaptation to high altitude hypoxia, the hub genes that DDX24, PDCD11, EIF4A3, NDUFA11, SART1, PRPF8 and TCONS_00306477, TCONS_00306029, TCONS_00139593, TCONS_00293272, TCONS_00313398 were selected. Additionally, a set of target genes, PIK3R1, IGF1R, FZD6, IFNB2, ATF3, MB, CYP2B4, PSMD13, and TGFB1 were also identified as candidate genes associated with high altitude hypoxia adaptation. In conclusion, a collection of aberrantly expressed lncRNA, a set of target genes and biological pathways known to be relevant for altitude adaptation were identified by comparative transcriptome analysis between Tibetan sheep and Hu sheep. Our results first identified the characterization and expression profile of lncRNAs between Tibetan sheep and Hu sheep and provides insights into the genetic regulation mechanisms for Tibetan sheep adaptation to high altitude hypoxia environments.

Sign in / Sign up

Export Citation Format

Share Document