scholarly journals Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 35423-35436 ◽  
Author(s):  
Wei Wang ◽  
Xiao-Long Chen ◽  
Shen-Yu Zhao ◽  
Yu-Hui Xu ◽  
Wei-Han Zhang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum ◽  
Serum Ca125

scholarly journals Prognostic Significance of Elevated Preoperative Serum CA125 Levels After Curative Hepatectomy for Hepatocellular Carcinoma

2020 ◽  
Vol Volume 13 ◽  
pp. 4559-4567
Author(s):  
Yao Huang ◽  
Jianxing Zeng ◽  
Teng Liu ◽  
Xinju Lin ◽  
Pengfei Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum ◽  
Serum Ca125 ◽  
Curative Hepatectomy

Prognostic Significance of CEA, CA 19-9 and CA 72-4 Preoperative Serum Levels in Gastric Carcinoma

Oncology ◽  
1999 ◽  
Vol 57 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Daniele Marrelli ◽  
Franco Roviello ◽  
Alfonso De Stefano ◽  
Maurizio Farnetani ◽  
Lorenzo Garosi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Preoperative Serum

Preoperative serum CA125 as an independent predictor for recurrence and death in operable patients with non-small cell lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18520-e18520
Author(s):  
Jianguo Feng ◽  
Haiyan Xu ◽  
Hanmo Wu ◽  
Min Luo ◽  
Weimin Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Small Cell ◽  
Small Cell Lung ◽  
Kaplan Meier ◽  
Preoperative Serum ◽  
Serum Ca125

e18520 Background: The role of serum CA125 in the prognosis of non-small cell lung cancer (NSCLC) remains controversial, especially in early stage patients. The aim of this study is to analyze the prognostic value of CA125 in operable NSCLC. Methods: We retrospectively analyzed 645 patients with non-small cell lung cancer (NSCLC) who underwent curative surgical resection for lung cancer at Zhejiang Cancer Hospital of China from 2006 to 2011. Micropartical enzyme immunoassay was used to measure preoperative serum CA125. Pearson’s chi test was used in univariate analyses and a multivariable proportional hazard Cox regression model was applied to assess the prognostic significance of the different covariates. Kaplan-Meier was used to analyze survival curve. Results: The positive rate of preoperative serum CA125 was 18.9% (126/667) in all patients, and elevated CA125 concentration was associated to poorly differentiated tumor and advanced clinical stage. Moreover, CA125 was closely related to patient outcomes. The Kaplan-Meier survival curves were shown patient with normal CA125 concentration had significantly longer DFS (median DFS, not reach vs 21 months, p=0.000) and OS (median OS, 61 vs 29 months, p=0.000) than those with positive CA125. Multivariate Cox analysis indicated patients with positive CA125 had an elevated risk of disease recurrence or death compared with those who had negative one. The adjusted hazard ratio (HR) was 1.74 for replase (95% confidence interval [CI], 1.25-2.41, p=0.001) and 1.79 for death (95% CI, 1.34-2.41, p=0.000) after adjusted by age, gender, grade, stage, histology and smoking status. Conclusions: CA125 seems to play an important role in disease progression and it may be an independent predictive marker for prognosis in patients with NSCLC. [Table: see text]

The prognostic significance of maternal serum CA125 measurement in threatened abortion

1992 ◽  
Vol 46 (2-3) ◽  
pp. 137-142 ◽  
Author(s):  
Fahri Öçer ◽  
Tugan Beşe ◽  
Ertan Saridoǧan ◽  
Kiliç Aydinli ◽  
Turgay Atasü
Keyword(s):  
Prognostic Significance ◽  
Maternal Serum ◽  
Serum Ca125 ◽  
Threatened Abortion

scholarly journals Neuroendocrine differentiation in prostate cancer

2004 ◽  
Vol 61 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Snezana Cerovic ◽  
Goran Brajuskovic ◽  
Vinka Maletic-Vukotic ◽  
Sava Micic
Keyword(s):  
Prostate Cancer ◽  
Clinical Stage ◽  
Prognostic Significance ◽  
Specific Antigen ◽  
Neuron Specific Enolase ◽  
Neuroendocrine Differentiation ◽  
Current Evidence ◽  
Gleason Grade ◽  
Preoperative Serum ◽  
Significant Expression

Background. In numerous recent studies attention has been focused to neuroendocrine differentiation (NED) in prostate cancer (PC). Focal NED is present in almost all PCs, but it is prominent in only 5-10% of the carcinomas. The prognostic significance of focal NED in PC is controversial, but current evidence suggests its influence on the onset and/or conversion of hormon resistant tumor phenotype. The aim of this study was to evaluate the relationship between NED status, based only on immunohistochemical use of neuroendocrine (NE) markers, with PC grade and stage, and preoperative serum levels of prostate-specific antigen (PSA). Methods. The study included the biopsy material of 73 untreated PC patients (pts.) obtained by transurethral resection (TUR) (37 pts.), and radical retropubic prostatectomy (RRP) (36 pts.). Two representative tissue samples (tipically the block containing the largest amount of neoplasm) were selected for immunohistochemical (IMM) staining. NE cells were identified using a panel of IMM markers: chromogranin A, neuron-specific enolase, and serotonin. The level of PC exocrine differentiation was detected by monoclonal antibodies against PSA. Results. Significant expression of NE cells was demonstrated in 26 (70.2%) pts. with PC after TUR. In this group, serum preoperative PSA values ranged from 0.1 to 9.6 ng/ml. The majority of pts. with NED had low differentiated PC with Gleason grade score (GGS) >7, and normal PSA values below 4 ng/ml (77%), in clinical stage D (54%). Statistically significant correlation (p<0.01) of positive NED with higher stage and grade and low PSA values was established. Among the pts. with localized PC in whom RRP was performed (n=36), significant expression of NE cells was found in 15 pts. (41.7%), 8 (53.3%) in pT2 stage, and 7 (46.7%) in pT3 stage. Significant correlation between NED with preoperative PSA values and stage of PC in pts. with RRP was not found. Conclusion. We demonstrated the significant NED in poorly differentiated PC in patients in the advanced stage of the disease. The expression of NED in organ-confined PC did not correlate with tumor stage, but it correlated with tumor grade (GGS?7).

scholarly journals The significance of blood cell biomarkers in the prognosis of gastric cancer

2020 ◽  
Author(s):  
Pu Huang ◽  
Yiran Zhang ◽  
Anqiang Wang ◽  
Zhao-de Bu
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Blood Cell ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Vascular Tumor ◽  
Tumor Differentiation ◽  
Chi Square ◽  
Preoperative Serum

Abstract Background Studies have shown that inflammation-associated blood cell markers are associated with prognoses in a variety of tumors. However, the prognostic significance of these markers for gastric cancer (GC) is still not very clear. This article aims to explore its value of GC prognostic assessment.Methods From July 2011 to July 2016, 353 GC patients with surgical treatment were enrolled in this retrospective study. Patients’ demographics were analyzed along with clinical and pathologic data. The chi-square test was used to evaluate relationships between the markers and other clinicopathological variables; The Kaplan–Meier method and Cox regression proportional hazard model were performed to evaluate prognostic factors.Results Univariate analysis indicated T stage, N stage, vascular tumor thrombus, tumor long diameter, Bormann Classification, preoperative MWR (monocyte/leukocyte ratio), preoperative serum CEA levels are prognostic factors for GC. Multivariate analysis showed that preoperative MWR, tumor differentiation, and tumor length were independent prognostic factors in patients with GC. The boundary value of MWR is 0.8.Conclusion Preoperative MWR was convenient, simple marker of gastric cancer, might be useful for the evaluation of prognosis of patients with GC. Comparing with TNM stage, tumor differentiation was a more reliable pathological factor evaluating recurrence.

The Prognostic Significance of the Tumor-Infiltrating FoxP3-Positive Regulatory T Cells in Gastric Carcinoma

2010 ◽  
Vol 44 (1) ◽  
pp. 9 ◽  
Author(s):  
Sang Jae Noh ◽  
Shin Young Park ◽  
Kyung Ryoul Kim ◽  
Chan Young Kim ◽  
Keun Sang Kwon ◽  
...  
Keyword(s):  
T Cells ◽  
Gastric Carcinoma ◽  
Regulatory T Cells ◽  
Prognostic Significance

scholarly journals Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Sanshun Zhou ◽  
Zusen Wang ◽  
Manjiang Li ◽  
Liqun Wu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
R0 Resection ◽  
Tumor Diameter ◽  
Cancer Antigen 125 ◽  
Preoperative Serum ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Patient Groups

Aim. Little is known about the association between cancer antigen 125 (MUC16/CA125) concentrations and tumor diameter of patients with hepatocellular carcinoma (HCC) and low AFP levels. To fill this gap in our knowledge, we conducted a retrospective study of 427 patients with HCC with AFP ≤200 ng/mL who underwent R0 resection at our center. Methods. The associations between CA125 concentrations and patients’ clinicopathological characteristics were analyzed. Survival vs CA125 levels was also evaluated between patient groups with CA125 ≤30 U/mL or CA125 >30 U/mL. Independent risk factors of disease-free survival (DFS) and overall survival (OS) were analyzed with Cox hazard regression model. Results. Elevated preoperative serum CA125 was significantly associated with maximal tumor diameter (MTD) >5 cm and female sex (P<0.001 and P=0.044, respectively). The DFS and OS of patients with CA125 ≤30 U/mL (n = 392) were significantly higher compared with those with CA125 >30 U/mL (n = 35) (P=0.003 and P=0.001 respectively). Multivariate analysis revealed that MTD >5 cm was an independent risk factor of DFS (HR = 1.891, 95% CI: 1.379–2.592, P<0.001) and OS (2.709, 1.848–3.972, P<0.001). Conclusions. In conclusion, elevated preoperative serum CA125 predicted larger tumor diameter and poor prognosis after patients with HCC with AFP ≤200 ng/mL underwent R0 resection, which may be explained by the elevation of the preoperative serum CA125 level significantly associated with MTD>5 cm.

Sign in / Sign up

Export Citation Format

Share Document