scholarly journals Prognostic Significance of Elevated Preoperative Serum CA125 Levels After Curative Hepatectomy for Hepatocellular Carcinoma

2020 ◽  
Vol Volume 13 ◽  
pp. 4559-4567
Author(s):  
Yao Huang ◽  
Jianxing Zeng ◽  
Teng Liu ◽  
Xinju Lin ◽  
Pengfei Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum ◽  
Serum Ca125 ◽  
Curative Hepatectomy

scholarly journals Elevated Preoperative Serum CA125 Predicts Larger Tumor Diameter in Patients with Hepatocellular Carcinoma and Low AFP Levels

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Sanshun Zhou ◽  
Zusen Wang ◽  
Manjiang Li ◽  
Liqun Wu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
R0 Resection ◽  
Tumor Diameter ◽  
Cancer Antigen 125 ◽  
Preoperative Serum ◽  
Serum Ca125 ◽  
Serum Ca125 Level ◽  
Patient Groups

Aim. Little is known about the association between cancer antigen 125 (MUC16/CA125) concentrations and tumor diameter of patients with hepatocellular carcinoma (HCC) and low AFP levels. To fill this gap in our knowledge, we conducted a retrospective study of 427 patients with HCC with AFP ≤200 ng/mL who underwent R0 resection at our center. Methods. The associations between CA125 concentrations and patients’ clinicopathological characteristics were analyzed. Survival vs CA125 levels was also evaluated between patient groups with CA125 ≤30 U/mL or CA125 >30 U/mL. Independent risk factors of disease-free survival (DFS) and overall survival (OS) were analyzed with Cox hazard regression model. Results. Elevated preoperative serum CA125 was significantly associated with maximal tumor diameter (MTD) >5 cm and female sex (P<0.001 and P=0.044, respectively). The DFS and OS of patients with CA125 ≤30 U/mL (n = 392) were significantly higher compared with those with CA125 >30 U/mL (n = 35) (P=0.003 and P=0.001 respectively). Multivariate analysis revealed that MTD >5 cm was an independent risk factor of DFS (HR = 1.891, 95% CI: 1.379–2.592, P<0.001) and OS (2.709, 1.848–3.972, P<0.001). Conclusions. In conclusion, elevated preoperative serum CA125 predicted larger tumor diameter and poor prognosis after patients with HCC with AFP ≤200 ng/mL underwent R0 resection, which may be explained by the elevation of the preoperative serum CA125 level significantly associated with MTD>5 cm.

scholarly journals Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 35423-35436 ◽  
Author(s):  
Wei Wang ◽  
Xiao-Long Chen ◽  
Shen-Yu Zhao ◽  
Yu-Hui Xu ◽  
Wei-Han Zhang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum ◽  
Serum Ca125

scholarly journals Expression Status and Prognostic Significance of Gamma-Glutamyl Transpeptidase Family Genes in Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Shan Tian ◽  
Jiao Li ◽  
Yingyun Guo ◽  
Weiguo Dong ◽  
Xin Zheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Prognostic Value ◽  
Expression Patterns ◽  
Prognostic Significance ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Spearman Coefficient ◽  
Glutamyl Transpeptidase ◽  
Curative Hepatectomy

PurposeGamma-glutamyl transpeptidase (GGT) family genes play crucial roles in the formation and progression of several solid tumors. However, the expression patterns and the prognostic significance of GGT members in hepatocellular carcinoma (HCC) remain unknown. This study was designed to determine the expression profiles of GGT family members in HCC and validate the prognostic value of serum GGT protein in patients with HCC.MethodWe comprehensively searched public resources based on the LIHC dataset to determine the expression patterns, prognostic significance, DNA methylation status, immune infiltration, and biological pathways of GGT family genes in HCC. Subsequently, we validated the prognostic value of serum GGT protein in 85 patients with early-stage HCC subjected to curative hepatectomy from the Renmin Hospital of Wuhan University.ResultsExcept for GGT1, other GGT family members (GGT5, GGT6, and GGT7) were found to be differentially expressed in primary HCC samples (N = 371) and normal control tissues (N = 50). Furthermore, a positive relationship was not only observed between GGT1 and GGT5 (Spearman coefficient: 0.24, P = 5.143 × 10−6) but also between GGT5 and GGT6 (Spearman coefficient: 0.38, P = 1.24 × 10−13). The expression of GGT1, GGT5, and GGT7 was correlated with overall survival (OS), and GGT7 was associated with disease-free survival (DFS) in patients with HCC. Negative associations between DNA methylation and expression of mRNA were observed for GGT1 (Spearman coefficient: −0.38, P = 6.24e-14), GGT6 (Spearman coefficient: −0.29, P = 1.23e-8), and GGT7 (Spearman coefficient: −0.34, P=6.7e-11). GGT family genes were well correlated with the infiltration levels of immune cells in HCC, especially CD4+ T cells, macrophages, and dendritic cells. Finally, when validated with clinical data from the Renmin cohort, a high expression of serum GGT protein was identified as a strong prognostic element of unfavorable OS (HR = 3.114, P = 0.025), but not of DFS (HR = 1.198, P = 0.05) in patients with HCC subjected to curative hepatectomy.ConclusionTo our knowledge, this is the first comprehensive analysis of the expression patterns and clinical value of GGT family genes in patients with HCC. Our study laid the foundation for the clinical application of the GGT protein in the survival assessment of patients with HCC.

Clinicopathological and Prognostic Significance of Preoperative Serum Zinc Status in Patients with Hepatocellular Carcinoma After Initial Hepatectomy

2014 ◽  
Vol 21 (12) ◽  
pp. 3817-3826 ◽  
Author(s):  
Katsunori Imai ◽  
Toru Beppu ◽  
Takanobu Yamao ◽  
Hirohisa Okabe ◽  
Hiromitsu Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Significance ◽  
Serum Zinc ◽  
Zinc Status ◽  
Initial Hepatectomy ◽  
Preoperative Serum

Prognostic Significance of Antithrombin III Levels for Outcomes in Patients with Hepatocellular Carcinoma After Curative Hepatectomy

2012 ◽  
Vol 19 (9) ◽  
pp. 2888-2896 ◽  
Author(s):  
Hiroshi Iwako ◽  
Hirotaka Tashiro ◽  
Hironobu Amano ◽  
Yoshisato Tanimoto ◽  
Akihiko Oshita ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antithrombin Iii ◽  
Prognostic Significance ◽  
Curative Hepatectomy

Preoperative serum CA125 as an independent predictor for recurrence and death in operable patients with non-small cell lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18520-e18520
Author(s):  
Jianguo Feng ◽  
Haiyan Xu ◽  
Hanmo Wu ◽  
Min Luo ◽  
Weimin Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Small Cell ◽  
Small Cell Lung ◽  
Kaplan Meier ◽  
Preoperative Serum ◽  
Serum Ca125

e18520 Background: The role of serum CA125 in the prognosis of non-small cell lung cancer (NSCLC) remains controversial, especially in early stage patients. The aim of this study is to analyze the prognostic value of CA125 in operable NSCLC. Methods: We retrospectively analyzed 645 patients with non-small cell lung cancer (NSCLC) who underwent curative surgical resection for lung cancer at Zhejiang Cancer Hospital of China from 2006 to 2011. Micropartical enzyme immunoassay was used to measure preoperative serum CA125. Pearson’s chi test was used in univariate analyses and a multivariable proportional hazard Cox regression model was applied to assess the prognostic significance of the different covariates. Kaplan-Meier was used to analyze survival curve. Results: The positive rate of preoperative serum CA125 was 18.9% (126/667) in all patients, and elevated CA125 concentration was associated to poorly differentiated tumor and advanced clinical stage. Moreover, CA125 was closely related to patient outcomes. The Kaplan-Meier survival curves were shown patient with normal CA125 concentration had significantly longer DFS (median DFS, not reach vs 21 months, p=0.000) and OS (median OS, 61 vs 29 months, p=0.000) than those with positive CA125. Multivariate Cox analysis indicated patients with positive CA125 had an elevated risk of disease recurrence or death compared with those who had negative one. The adjusted hazard ratio (HR) was 1.74 for replase (95% confidence interval [CI], 1.25-2.41, p=0.001) and 1.79 for death (95% CI, 1.34-2.41, p=0.000) after adjusted by age, gender, grade, stage, histology and smoking status. Conclusions: CA125 seems to play an important role in disease progression and it may be an independent predictive marker for prognosis in patients with NSCLC. [Table: see text]

Sign in / Sign up

Export Citation Format

Share Document