The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA

2001 ◽  
Vol 76 (4) ◽  
pp. 266-271 ◽  
Author(s):  
N�v??t Duraker ◽  
Al?? Nac?? �el??k
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum

scholarly journals Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 35423-35436 ◽  
Author(s):  
Wei Wang ◽  
Xiao-Long Chen ◽  
Shen-Yu Zhao ◽  
Yu-Hui Xu ◽  
Wei-Han Zhang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Preoperative Serum ◽  
Serum Ca125

Prognostic Significance of CEA, CA 19-9 and CA 72-4 Preoperative Serum Levels in Gastric Carcinoma

Oncology ◽  
1999 ◽  
Vol 57 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Daniele Marrelli ◽  
Franco Roviello ◽  
Alfonso De Stefano ◽  
Maurizio Farnetani ◽  
Lorenzo Garosi ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Preoperative Serum

scholarly journals Neuroendocrine differentiation in prostate cancer

2004 ◽  
Vol 61 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Snezana Cerovic ◽  
Goran Brajuskovic ◽  
Vinka Maletic-Vukotic ◽  
Sava Micic
Keyword(s):  
Prostate Cancer ◽  
Clinical Stage ◽  
Prognostic Significance ◽  
Specific Antigen ◽  
Neuron Specific Enolase ◽  
Neuroendocrine Differentiation ◽  
Current Evidence ◽  
Gleason Grade ◽  
Preoperative Serum ◽  
Significant Expression

Background. In numerous recent studies attention has been focused to neuroendocrine differentiation (NED) in prostate cancer (PC). Focal NED is present in almost all PCs, but it is prominent in only 5-10% of the carcinomas. The prognostic significance of focal NED in PC is controversial, but current evidence suggests its influence on the onset and/or conversion of hormon resistant tumor phenotype. The aim of this study was to evaluate the relationship between NED status, based only on immunohistochemical use of neuroendocrine (NE) markers, with PC grade and stage, and preoperative serum levels of prostate-specific antigen (PSA). Methods. The study included the biopsy material of 73 untreated PC patients (pts.) obtained by transurethral resection (TUR) (37 pts.), and radical retropubic prostatectomy (RRP) (36 pts.). Two representative tissue samples (tipically the block containing the largest amount of neoplasm) were selected for immunohistochemical (IMM) staining. NE cells were identified using a panel of IMM markers: chromogranin A, neuron-specific enolase, and serotonin. The level of PC exocrine differentiation was detected by monoclonal antibodies against PSA. Results. Significant expression of NE cells was demonstrated in 26 (70.2%) pts. with PC after TUR. In this group, serum preoperative PSA values ranged from 0.1 to 9.6 ng/ml. The majority of pts. with NED had low differentiated PC with Gleason grade score (GGS) >7, and normal PSA values below 4 ng/ml (77%), in clinical stage D (54%). Statistically significant correlation (p<0.01) of positive NED with higher stage and grade and low PSA values was established. Among the pts. with localized PC in whom RRP was performed (n=36), significant expression of NE cells was found in 15 pts. (41.7%), 8 (53.3%) in pT2 stage, and 7 (46.7%) in pT3 stage. Significant correlation between NED with preoperative PSA values and stage of PC in pts. with RRP was not found. Conclusion. We demonstrated the significant NED in poorly differentiated PC in patients in the advanced stage of the disease. The expression of NED in organ-confined PC did not correlate with tumor stage, but it correlated with tumor grade (GGS?7).

scholarly journals The significance of blood cell biomarkers in the prognosis of gastric cancer

2020 ◽  
Author(s):  
Pu Huang ◽  
Yiran Zhang ◽  
Anqiang Wang ◽  
Zhao-de Bu
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Blood Cell ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Vascular Tumor ◽  
Tumor Differentiation ◽  
Chi Square ◽  
Preoperative Serum

Abstract Background Studies have shown that inflammation-associated blood cell markers are associated with prognoses in a variety of tumors. However, the prognostic significance of these markers for gastric cancer (GC) is still not very clear. This article aims to explore its value of GC prognostic assessment.Methods From July 2011 to July 2016, 353 GC patients with surgical treatment were enrolled in this retrospective study. Patients’ demographics were analyzed along with clinical and pathologic data. The chi-square test was used to evaluate relationships between the markers and other clinicopathological variables; The Kaplan–Meier method and Cox regression proportional hazard model were performed to evaluate prognostic factors.Results Univariate analysis indicated T stage, N stage, vascular tumor thrombus, tumor long diameter, Bormann Classification, preoperative MWR (monocyte/leukocyte ratio), preoperative serum CEA levels are prognostic factors for GC. Multivariate analysis showed that preoperative MWR, tumor differentiation, and tumor length were independent prognostic factors in patients with GC. The boundary value of MWR is 0.8.Conclusion Preoperative MWR was convenient, simple marker of gastric cancer, might be useful for the evaluation of prognosis of patients with GC. Comparing with TNM stage, tumor differentiation was a more reliable pathological factor evaluating recurrence.

The Prognostic Significance of the Tumor-Infiltrating FoxP3-Positive Regulatory T Cells in Gastric Carcinoma

2010 ◽  
Vol 44 (1) ◽  
pp. 9 ◽  
Author(s):  
Sang Jae Noh ◽  
Shin Young Park ◽  
Kyung Ryoul Kim ◽  
Chan Young Kim ◽  
Keun Sang Kwon ◽  
...  
Keyword(s):  
T Cells ◽  
Gastric Carcinoma ◽  
Regulatory T Cells ◽  
Prognostic Significance

Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5

2011 ◽  
Vol 15 (8) ◽  
pp. 1336-1343 ◽  
Author(s):  
Hae-Wan Lee ◽  
Soo Kee Min ◽  
Young-Su Ju ◽  
Joohon Sung ◽  
Man Sup Lim ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Prognostic Significance ◽  
Hla Class I ◽  
Class I

scholarly journals The prognostic significance of preoperative serum albumin in urothelial carcinoma: a systematic review and meta-analysis

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Jing Liu ◽  
Fang Wang ◽  
Shaohong Li ◽  
Wenhui Huang ◽  
Yanjuan Jia ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Urothelial Carcinoma ◽  
Serum Albumin Level ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Albumin Level ◽  
Cochrane Library ◽  
Tumor Type ◽  
Poor Overall Survival ◽  
Preoperative Serum

Preoperative serum albumin has been considered to be closely correlated with the prognosis of various cancers, including urothelial carcinoma (UC). However, to date, this conclusion remains controversial. The aim of this meta-analysis is to investigate the prognostic significance of preoperative serum albumin in UC. A literature search was performed in PubMed, Web of Science, Embase, and Cochrane Library up to 4 July 2017. Herein, a total of 15506 patients from 23 studies were enrolled in our meta-analysis. Decreased preoperative serum albumin level predicted poor overall survival (OS) (HR = 1.88, 95% CI: 1.44–2.45, P<0.0001), cancer-specific survival (CSS) (HR = 2.03, 95% CI: 1.42–2.90, P=0.0001), recurrence-free survival (HR = 1.85, 95% CI: 1.15–2.97, P=0.01), 30-day complications (30dCs) after surgery (odds ratio (OR) = 1.93, 95% CI: 1.16–3.20, P=0.01), and 90-day mortality after surgery (OR = 4.24, 95% CI: 2.20–8.16, P<0.001). The subgroup analyses indicated that low preoperative serum albumin level is still positively associated with a worse prognosis of UC based on ethnicity, cut-off value, tumor type, analyses type, and sample size. Our meta-analysis indicated that reduced preoperative serum albumin level was a predictor of poor prognosis of UC.

Prognostic significance of the expression of MUC1 and collagen type IV in advanced gastric carcinoma

2009 ◽  
Vol 96 (8) ◽  
pp. 901-909 ◽  
Author(s):  
H. Ando ◽  
R. Aihara ◽  
T. Ohno ◽  
K. Ogata ◽  
E. Mochiki ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Collagen Type ◽  
Prognostic Significance ◽  
Collagen Type Iv ◽  
Type Iv ◽  
Advanced Gastric Carcinoma

scholarly journals Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma

2013 ◽  
Vol 47 (3) ◽  
pp. 219 ◽  
Author(s):  
Youngran Kang ◽  
Woon Yong Jung ◽  
Hyunjoo Lee ◽  
Wonkyung Jung ◽  
Eunjung Lee ◽  
...  
Keyword(s):  
Heat Shock ◽  
Gastric Carcinoma ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Prognostic Significance ◽  
Early Gastric Carcinoma
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