A Novel Prodrug of a γ-Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer

ChemMedChem ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 155-163 ◽  
Author(s):  
Hiromi Ii ◽  
Taku Yoshiya ◽  
Susumu Nakata ◽  
Keiko Taniguchi ◽  
Koushi Hidaka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Mouse Model ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Xenograft Mouse Model ◽  
Proliferation In Vitro

Inhibition of Cancer Cell Proliferation in vitro and Tumor Growth in vivo by Hydrophis spiralis Sea Snake Venom

2007 ◽  
Vol 3 (4) ◽  
pp. 186-190
Author(s):  
R. Karthikeya ◽  
S. Karthigaya ◽  
M. Sri Balasubash ◽  
S. Vijayalaks ◽  
S.T. Somasundar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Snake Venom ◽  
Cancer Cell Proliferation ◽  
Sea Snake ◽  
Proliferation In Vitro

scholarly journals Prostate Cancer Cell Proliferation In vitro Is Modulated by Antibodies against Glucose-Regulated Protein 78 Isolated from Patient Serum

2006 ◽  
Vol 66 (23) ◽  
pp. 11424-11431 ◽  
Author(s):  
Mario Gonzalez-Gronow ◽  
Miguel Cuchacovich ◽  
Carolina Llanos ◽  
Cristian Urzua ◽  
Govind Gawdi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Proliferation In Vitro ◽  
Glucose Regulated Protein

scholarly journals Early Cardiac Remodeling Promotes Tumor Growth and Metastasis

Circulation ◽  
2020 ◽  
Vol 142 (7) ◽  
pp. 670-683 ◽  
Author(s):  
Shimrit Avraham ◽  
Soraya Abu-Sharki ◽  
Rona Shofti ◽  
Tali Haas ◽  
Ben Korin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Cardiac Remodeling ◽  
Cancer Cell Proliferation ◽  
Tumor Growth And Metastasis ◽  
Proliferation In Vitro

Background: Recent evidence suggests that cancer and cardiovascular diseases are associated. Chemotherapy drugs are known to result in cardiotoxicity, and studies have shown that heart failure and stress correlate with poor cancer prognosis. However, whether cardiac remodeling in the absence of heart failure is sufficient to promote cancer is unknown. Methods: To investigate the effect of early cardiac remodeling on tumor growth and metastasis colonization, we used transverse aortic constriction (TAC), a model for pressure overload–induced cardiac hypertrophy, and followed it by cancer cell implantation. Results: TAC-operated mice developed larger primary tumors with a higher proliferation rate and displayed more metastatic lesions compared with controls. Serum derived from TAC-operated mice potentiated cancer cell proliferation in vitro, suggesting the existence of secreted tumor-promoting factors. Using RNA-sequencing data, we identified elevated mRNA levels of periostin in the hearts of TAC-operated mice. Periostin levels were also found to be high in the serum after TAC. Depletion of periostin from the serum abrogated the proliferation of cancer cells; conversely, the addition of periostin enhanced cancer cell proliferation in vitro. This is the first study to show that early cardiac remodeling nurtures tumor growth and metastasis and therefore promotes cancer progression. Conclusions: Our study highlights the importance of early diagnosis and treatment of cardiac remodeling because it may attenuate cancer progression and improve cancer outcome.

scholarly journals Apolipoprotein C1 promotes prostate cancer cell proliferation in vitro

2018 ◽  
Vol 32 (7) ◽  
pp. e22158 ◽  
Author(s):  
Wei-peng Su ◽  
Li-na Sun ◽  
Shun-liang Yang ◽  
Hu Zhao ◽  
Teng-yue Zeng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Proliferation In Vitro

PEG–PHB-glutaminase nanoparticle inhibits cancer cell proliferation in vitro through glutamine deprivation

2014 ◽  
Vol 51 (4) ◽  
pp. 372-380 ◽  
Author(s):  
Sureshbabu Ram Kumar Pandian ◽  
Venkataraman Deepak ◽  
Hariharan Nellaiah ◽  
Krishnan Sundar
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Glutamine Deprivation ◽  
Proliferation In Vitro

scholarly journals Polar biophenolics in sweet potato greens extract synergize to inhibit prostate cancer cell proliferation and in vivo tumor growth

2013 ◽  
Vol 34 (9) ◽  
pp. 2039-2049 ◽  
Author(s):  
Sushma R. Gundala ◽  
Chunhua Yang ◽  
N. Lakshminarayana ◽  
Ghazia Asif ◽  
Meenakshi V. Gupta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Tumor Growth ◽  
Sweet Potato ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation
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