EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy

Yun-Tian Li; Xiao-Jun Qian; Yan Yu; Zhen-Hua Li; Rui-Yan Wu; Jiao Ji; Lin Jiao; Xuan Li; Peng-Fei Kong; Wen-Dan Chen; Gong-Kan Feng; Rong Deng; Xiao-Feng Zhu

doi:10.18632/oncotarget.3959

EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy

Oncotarget ◽

10.18632/oncotarget.3959 ◽

2015 ◽

Vol 6 (19) ◽

pp. 17491-17500 ◽

Cited By ~ 4

Author(s):

Yun-Tian Li ◽

Xiao-Jun Qian ◽

Yan Yu ◽

Zhen-Hua Li ◽

Rui-Yan Wu ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Caspase 8 ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Abstract 122: Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells

10.1158/1538-7445.am2019-122 ◽

2019 ◽

Author(s):

Ting Zhang ◽

Lixia Guo ◽

Yuanyuan Wang ◽

Tao Ren ◽

Yanan Yang

Keyword(s):

Lung Cancer ◽

Extracellular Matrix ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Abstract LB-126: PPARgamma agonists sensitize PTEN-deficient lung cancer cells resistant to EGFR tyrosine kinase inhibitors

10.1158/1538-7445.am2017-lb-126 ◽

2017 ◽

Author(s):

Kenneth KW To ◽

Wing Sum Tong ◽

William KK Wu ◽

Herbert HF Loong

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors

The Prostate ◽

10.1002/pros.20757 ◽

2008 ◽

Vol 68 (9) ◽

pp. 965-974 ◽

Cited By ~ 23

Author(s):

Claudio Festuccia ◽

Giovanni Luca Gravina ◽

Paola Muzi ◽

Danilo Millimaggi ◽

Vincenza Dolo ◽

...

Keyword(s):

Prostate Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Human Prostate ◽

Human Prostate Cancer ◽

Prostate Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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485 POSTER Activation of alternative HER receptors mediates resistance to EGFR tyrosine kinase inhibitors in breast cancer cells

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(08)72419-4 ◽

2008 ◽

Vol 6 (12) ◽

pp. 155

Author(s):

A. Kong ◽

V. Calleja ◽

P. Leboucher ◽

A. Harris ◽

P. Parker ◽

...

Keyword(s):

Breast Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Breast Cancer Cells ◽

Kinase Inhibitors ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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HER2 Oncogenic Function Escapes EGFR Tyrosine Kinase Inhibitors via Activation of Alternative HER Receptors in Breast Cancer Cells

PLoS ONE ◽

10.1371/journal.pone.0002881 ◽

2008 ◽

Vol 3 (8) ◽

pp. e2881 ◽

Cited By ~ 52

Author(s):

Anthony Kong ◽

Véronique Calleja ◽

Pierre Leboucher ◽

Adrian Harris ◽

Peter J. Parker ◽

...

Keyword(s):

Breast Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Breast Cancer Cells ◽

Kinase Inhibitors ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Oncogenic Function

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Microrna-144 Expression Overcomes Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Cells by Targeting Survivin

CHEST Journal ◽

10.1016/j.chest.2016.08.809 ◽

2016 ◽

Vol 150 (4) ◽

pp. 714A

Author(s):

Ki Eun Hwang ◽

Eun-Taik Jeong ◽

Hak-Ryul Kim

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

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Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells

PLoS ONE ◽

10.1371/journal.pone.0041017 ◽

2012 ◽

Vol 7 (7) ◽

pp. e41017 ◽

Cited By ~ 37

Author(s):

Keisuke Tabara ◽

Rina Kanda ◽

Kahori Sonoda ◽

Takuya Kubo ◽

Yuichi Murakami ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutant Gene ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

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The Effect of Acquired Cisplatin Resistance on Sensitivity to EGFR Tyrosine Kinase Inhibitors in EGFR Mutant Lung Cancer Cells

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics ◽

10.3727/096504012x13285365944337 ◽

2011 ◽

Vol 19 (10) ◽

pp. 471-478 ◽

Cited By ~ 3

Author(s):

Jin Kyung Rho ◽

Yun Jung Choi ◽

You Ri Choi ◽

Sun Ye Kim ◽

Su Jin Choi ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Cisplatin Resistance ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

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EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors

The Prostate ◽

10.1002/pros.22692 ◽

2013 ◽

Vol 73 (13) ◽

pp. 1453-1461 ◽

Cited By ~ 21

Author(s):

Jiangong Ren ◽

Lakshmi R. Bollu ◽

Fei Su ◽

Guang Gao ◽

Lei Xu ◽

...

Keyword(s):

Prostate Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Prostate Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

Journal of Clinical Investigation ◽

10.1172/jci34588 ◽

2008 ◽

Cited By ~ 23

Author(s):

Marta Guix ◽

Anthony C. Faber ◽

Shizhen Emily Wang ◽

Maria Graciela Olivares ◽

Youngchul Song ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Binding Proteins ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Igf Binding Proteins ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Igf Binding

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