Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

Journal of Clinical Investigation ◽

10.1172/jci34588 ◽

2008 ◽

Cited By ~ 23

Author(s):

Marta Guix ◽

Anthony C. Faber ◽

Shizhen Emily Wang ◽

Maria Graciela Olivares ◽

Youngchul Song ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Binding Proteins ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Igf Binding Proteins ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Igf Binding

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Faculty Opinions recommendation of Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725301254.793502902 ◽

2015 ◽

Author(s):

Alex Toker ◽

Kristin Brown

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Binding Proteins ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Igf Binding Proteins ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Igf Binding

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Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells

PLoS ONE ◽

10.1371/journal.pone.0041017 ◽

2012 ◽

Vol 7 (7) ◽

pp. e41017 ◽

Cited By ~ 37

Author(s):

Keisuke Tabara ◽

Rina Kanda ◽

Kahori Sonoda ◽

Takuya Kubo ◽

Yuichi Murakami ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutant Gene ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

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P76.85 Afatinib and Necitumumab in EGFR mutant NSCLC with Acquired Resistance to 1st or 3rd Generation EGFR Tyrosine Kinase Inhibitors

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1142 ◽

2021 ◽

Vol 16 (3) ◽

pp. S626

Author(s):

S. Padda ◽

J. Whisenant ◽

J. Neal ◽

S. York ◽

W. Iams ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Egfr Mutant

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Abstract 122: Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells

10.1158/1538-7445.am2019-122 ◽

2019 ◽

Author(s):

Ting Zhang ◽

Lixia Guo ◽

Yuanyuan Wang ◽

Tao Ren ◽

Yanan Yang

Keyword(s):

Lung Cancer ◽

Extracellular Matrix ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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EGFR tyrosine kinase inhibitors promote pro-caspase-8 dimerization that sensitizes cancer cells to DNA-damaging therapy

Oncotarget ◽

10.18632/oncotarget.3959 ◽

2015 ◽

Vol 6 (19) ◽

pp. 17491-17500 ◽

Cited By ~ 4

Author(s):

Yun-Tian Li ◽

Xiao-Jun Qian ◽

Yan Yu ◽

Zhen-Hua Li ◽

Rui-Yan Wu ◽

...

Keyword(s):

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Caspase 8 ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

BMC Cancer ◽

10.1186/s12885-020-06920-3 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Svenja Wagener-Ryczek ◽

Carina Heydt ◽

Juliane Süptitz ◽

Sebastian Michels ◽

Markus Falk ◽

...

Keyword(s):

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Mutational Spectrum ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Abstract 742: Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

10.1158/1538-7445.am2015-742 ◽

2015 ◽

Author(s):

Yuho Maki ◽

Shinsuke Hashida ◽

Hiromasa Yamamoto ◽

Kazuhiko Shien ◽

Tomoaki Ohtsuka ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Cell Lines ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Hsp90 Inhibitor ◽

Adenocarcinoma Cell ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Abstract LB-126: PPARgamma agonists sensitize PTEN-deficient lung cancer cells resistant to EGFR tyrosine kinase inhibitors

10.1158/1538-7445.am2017-lb-126 ◽

2017 ◽

Author(s):

Kenneth KW To ◽

Wing Sum Tong ◽

William KK Wu ◽

Herbert HF Loong

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Lung Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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An activation of LC3A-mediated autophagy contributes tode novoand acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma

The Journal of Pathology ◽

10.1002/path.4354 ◽

2014 ◽

pp. n/a-n/a ◽

Cited By ~ 9

Author(s):

Kaito Nihira ◽

Yasuhiro Miki ◽

Shinya Iida ◽

Sodai Narumi ◽

Katsuhiko Ono ◽

...

Keyword(s):

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors

The Prostate ◽

10.1002/pros.20757 ◽

2008 ◽

Vol 68 (9) ◽

pp. 965-974 ◽

Cited By ~ 23

Author(s):

Claudio Festuccia ◽

Giovanni Luca Gravina ◽

Paola Muzi ◽

Danilo Millimaggi ◽

Vincenza Dolo ◽

...

Keyword(s):

Prostate Cancer ◽

Tyrosine Kinase ◽

Cancer Cells ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Human Prostate ◽

Human Prostate Cancer ◽

Prostate Cancer Cells ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors

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