scholarly journals Methylation ofMGMTandADAMTS14in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

Oncotarget ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 3420-3431 ◽  
Author(s):  
Sergio Alonso ◽  
Yuichi Dai ◽  
Kentaro Yamashita ◽  
Shina Horiuchi ◽  
Tomoko Dai ◽  
...  
Keyword(s):  
African Americans ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Field Defect

scholarly journals Mast cells in adjacent normal colon mucosa rather than those in invasive margin are related to progression of colon cancer

2011 ◽  
Vol 23 (4) ◽  
pp. 276-282 ◽  
Author(s):  
Qing Xia ◽  
Ya Ding ◽  
Xiao-jun Wu ◽  
Rui-qing Peng ◽  
Qiang Zhou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mast Cells ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Invasive Margin ◽  
Normal Colon Mucosa

scholarly journals LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 23820-23836 ◽  
Author(s):  
Changhua Zhuo ◽  
Qingguo Li ◽  
Yuchen Wu ◽  
Yiwei Li ◽  
Jia Nie ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Chinese Patients ◽  
Colon Mucosa ◽  
Poor Survival ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Sporadic Colon Cancer

Asymmetric crypt fission in sessile serrated lesions

2020 ◽  
pp. jclinpath-2020-207008 ◽  
Author(s):  
Carlos A Rubio ◽  
Peter T Schmidt
Keyword(s):  
Somatic Mutations ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Crypt Fission ◽  
Tumour Suppressor Protein ◽  
Serrated Lesions ◽  
Symmetric Fission ◽  
Proliferating Cell ◽  
Asymmetric Fission

ObjectiveSessile serrated lesions without dysplasia (SSL-ND) are epitomised by dilated crypts with epithelial serrations and architectural distortions portraying boot-shapes, L-shapes or inverted-T shapes. Recently, crypts in asymmetric fission were detected in SSL-ND. The purpose was to assess the frequency of crypts in asymmetric fission in a cohort of SSL-ND.MethodsThe frequency of crypts in fission was assessed in 60 SSL-ND, the distribution of cell proliferation in 48 SSL-ND and the expression of maspin, a tumour-suppressor protein, in 29 SSL-ND.ResultsOut of the 60 SSL-ND, 40 (66.7%) showed crypts in fission: 39 (65%) SSL-ND had crypts in asymmetric fission and one SSL-ND (1.7%), in symmetric fission (p<0.05). Of 1495 crypts recorded in the 60 SSL-ND, 73 (4.9%) were in asymmetric fission but only one (0.06%), in symmetric fission (p<0.05). Out of the 48 Ki67-immunostained SSL-ND,15 (31%) showed randomly distributed proliferating cell-domains. All 29 SSL-ND revealed maspin-upregulation (including crypts in asymmetric and symmetric fission). In contrast, the normal colon mucosa showed occasional single crypts in symmetric fission, proliferating cell-domains limited to the lower thirds of the crypts, absence of crypts in asymmetric fission and remained maspin negative.ConclusionsSSL-ND thrive with crypts in asymmetric fission displaying randomly distributed proliferating cell-domains and maspin-upregulation. These histo-biological aberrations disclose pathological cryptogenesis and suggest possibly unfolding somatic mutations in SSL-ND. The present findings may open new vistas on the parameters pertinent to the susceptibility of SSL-ND to develop dysplasia and carcinoma.

scholarly journals Peptide YY-like immunoreactivity in normal colon mucosa, muscle layer and adenocarcinoma.

1987 ◽  
Vol 26 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Akira TARI ◽  
Yukitaka MIYACHI ◽  
Koji SUMII ◽  
Goro KAJIYAMA ◽  
Akima MIYOSHI
Keyword(s):  
Peptide Yy ◽  
Muscle Layer ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa

Expression of Gelatinase-A (MMP-2) in Human Colon Cancer and Normal Colon Mucosa

Tumor Biology ◽  
2001 ◽  
Vol 22 (6) ◽  
pp. 383-389 ◽  
Author(s):  
S. Papadopoulou ◽  
A. Scorilas ◽  
N. Arnogianaki ◽  
B. Papapanayiotou ◽  
A. Tzimogiani ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Gelatinase A ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Human Colon Cancer ◽  
Normal Colon Mucosa

scholarly journals Hyper-Elongation in Colorectal Cancer Tissue – Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies

2017 ◽  
Vol 41 (2) ◽  
pp. 722-730 ◽  
Author(s):  
Adriana Mika ◽  
Jaroslaw Kobiela ◽  
Aleksandra Czumaj ◽  
Michał Chmielewski ◽  
Piotr Stepnowski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tissue Expression ◽  
Gas Chromatography Mass Spectrometry ◽  
Cancer Tissue ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Colon Tissue ◽  
Normal Colon Mucosa ◽  
Metabolic Marker ◽  
Cerotic Acid

Backgrounds/Aims: Colorectal cancer (CRC) cells show some alterations of lipid metabolism. Elongation of fatty acids (FA) has not been studied in CRC tissues thus far. The aim of this study was to verify if CRC specimens and normal colon mucosa differ in terms of their levels of very long-chain FAs, a product of FA elongation. Moreover, the expression of elongase genes has been studied in normal tissue and CRC. Finally, we searched for some specific products of FA elongation in serum of CRC patients. Methods: The specimens of normal colon mucosa and CRC were obtained from nineteen CRC patients differ in terms of FA elongation. We also searched for some specific products of FA elongation in serum of CRC patients and from healthy volunteers. Tissue and serum FA profiles were determined by means of gas chromatography-mass spectrometry (GC/MS), and the tissue expression of elongases (ELOVLs) was analyzed with real-time PCR. Results: Compared to normal colon tissue, CRC specimens showed significantly higher levels of 22-, 24- and 26-carbon FAs, stronger expressions of ELOVL1 and ELOVL6 (4- and 9-fold elevated respectively), and higher values of 18: 0/16: 0 elongation index. We also demonstrated presence of cerotic acid (26: 0) in serum of all CRC patients but in none of the healthy controls. Conclusions: CRC tissue seems to be characterized by enhanced FA elongation (hyper-elongation). Presence of cerotic acid in CRC patients sera and absence of this FA in healthy subjects points to this compound as a strong candidate for specific metabolic marker of colorectal malignancies.

Sign in / Sign up

Export Citation Format

Share Document