scholarly journals LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 23820-23836 ◽  
Author(s):  
Changhua Zhuo ◽  
Qingguo Li ◽  
Yuchen Wu ◽  
Yiwei Li ◽  
Jia Nie ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Chinese Patients ◽  
Colon Mucosa ◽  
Poor Survival ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Sporadic Colon Cancer

scholarly journals Mast cells in adjacent normal colon mucosa rather than those in invasive margin are related to progression of colon cancer

2011 ◽  
Vol 23 (4) ◽  
pp. 276-282 ◽  
Author(s):  
Qing Xia ◽  
Ya Ding ◽  
Xiao-jun Wu ◽  
Rui-qing Peng ◽  
Qiang Zhou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mast Cells ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Invasive Margin ◽  
Normal Colon Mucosa

Expression of Gelatinase-A (MMP-2) in Human Colon Cancer and Normal Colon Mucosa

Tumor Biology ◽  
2001 ◽  
Vol 22 (6) ◽  
pp. 383-389 ◽  
Author(s):  
S. Papadopoulou ◽  
A. Scorilas ◽  
N. Arnogianaki ◽  
B. Papapanayiotou ◽  
A. Tzimogiani ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Gelatinase A ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Human Colon Cancer ◽  
Normal Colon Mucosa

Asymmetric crypt fission in sessile serrated lesions

2020 ◽  
pp. jclinpath-2020-207008 ◽  
Author(s):  
Carlos A Rubio ◽  
Peter T Schmidt
Keyword(s):  
Somatic Mutations ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Crypt Fission ◽  
Tumour Suppressor Protein ◽  
Serrated Lesions ◽  
Symmetric Fission ◽  
Proliferating Cell ◽  
Asymmetric Fission

ObjectiveSessile serrated lesions without dysplasia (SSL-ND) are epitomised by dilated crypts with epithelial serrations and architectural distortions portraying boot-shapes, L-shapes or inverted-T shapes. Recently, crypts in asymmetric fission were detected in SSL-ND. The purpose was to assess the frequency of crypts in asymmetric fission in a cohort of SSL-ND.MethodsThe frequency of crypts in fission was assessed in 60 SSL-ND, the distribution of cell proliferation in 48 SSL-ND and the expression of maspin, a tumour-suppressor protein, in 29 SSL-ND.ResultsOut of the 60 SSL-ND, 40 (66.7%) showed crypts in fission: 39 (65%) SSL-ND had crypts in asymmetric fission and one SSL-ND (1.7%), in symmetric fission (p<0.05). Of 1495 crypts recorded in the 60 SSL-ND, 73 (4.9%) were in asymmetric fission but only one (0.06%), in symmetric fission (p<0.05). Out of the 48 Ki67-immunostained SSL-ND,15 (31%) showed randomly distributed proliferating cell-domains. All 29 SSL-ND revealed maspin-upregulation (including crypts in asymmetric and symmetric fission). In contrast, the normal colon mucosa showed occasional single crypts in symmetric fission, proliferating cell-domains limited to the lower thirds of the crypts, absence of crypts in asymmetric fission and remained maspin negative.ConclusionsSSL-ND thrive with crypts in asymmetric fission displaying randomly distributed proliferating cell-domains and maspin-upregulation. These histo-biological aberrations disclose pathological cryptogenesis and suggest possibly unfolding somatic mutations in SSL-ND. The present findings may open new vistas on the parameters pertinent to the susceptibility of SSL-ND to develop dysplasia and carcinoma.

scholarly journals Peptide YY-like immunoreactivity in normal colon mucosa, muscle layer and adenocarcinoma.

1987 ◽  
Vol 26 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Akira TARI ◽  
Yukitaka MIYACHI ◽  
Koji SUMII ◽  
Goro KAJIYAMA ◽  
Akima MIYOSHI
Keyword(s):  
Peptide Yy ◽  
Muscle Layer ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa

scholarly journals Methylation ofMGMTandADAMTS14in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

Oncotarget ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 3420-3431 ◽  
Author(s):  
Sergio Alonso ◽  
Yuichi Dai ◽  
Kentaro Yamashita ◽  
Shina Horiuchi ◽  
Tomoko Dai ◽  
...  
Keyword(s):  
African Americans ◽  
Colon Mucosa ◽  
Normal Colon ◽  
Normal Colon Mucosa ◽  
Field Defect
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