scholarly journals WITHDRAWN: Associations between ten VEGF gene polymorphisms and susceptibility to type 2 diabetic retinopathy, proliferative diabetic retinopathy and nonproliferative diabetic retinopathy: a systematic review and meta-analysis

Oncotarget ◽  
2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Qianhui Yang ◽  
Qianhui Yang ◽  
Yan Zhang ◽  
Yan Zhang ◽  
Xiandi Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Vegf Gene ◽  
Nonproliferative Diabetic Retinopathy ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

scholarly journals Association of VEGF Gene Polymorphisms with Susceptibility to Diabetic Retinopathy: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 52 (05) ◽  
pp. 264-279
Author(s):  
Xiaorong Li ◽  
Juping Liu ◽  
Qianhui Yang ◽  
Yan Zhang ◽  
Xiaomin Zhang
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Vascular Endothelial ◽  
Nucleotide Polymorphisms ◽  
Vegf Gene ◽  
Asian Populations ◽  
Increased Risk ◽  
Endothelial Growth Factor

AbstractThe associations between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of type 2 diabetic retinopathy (DR) – proliferative diabetic retinopathy (PDR), and nonproliferative diabetic retinopathy (NPDR) – remain unclear. A systematic search and meta-analysis using odds ratio (OR) with 95% confidence interval (CI) was performed to evaluate the association. Our study concluded 26 studies containing 10 single nucleotide polymorphisms (SNPs). In Asian populations, rs3025039 polymorphism was associated with DR risk, while in overall populations and Caucasians, the DR risk was increased by association with rs2010963. There was a significant association between rs25648 and rs833061 and DR risk in Caucasians. DR risks were found to be significantly associated between rs3025021, rs13207351, and rs2146323 in either overall populations, Caucasians or Asians. Besides, in overall and Asian populations, rs699947 and rs3025039 were associated with PDR risk. rs1570360, rs3025039, and rs833061 played a key role in PDR etiology in Caucasians. rs2010963 was associated with increased risk of PDR in overall populations. A significant association between rs699947, rs3025039, and rs833061 and NPDR risk in overall populations and Asians was found. A significant association was observed between rs2010963 and increased NPDR risk in overall and Caucasian populations. This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR, and NPDR.

scholarly journals Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Suganthalakshmi Balasubbu ◽  
Periasamy Sundaresan ◽  
Anand Rajendran ◽  
Kim Ramasamy ◽  
Gowthaman Govindarajan ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Candidate Gene ◽  
Association Analysis ◽  
Gene Polymorphisms ◽  
Indian Patients ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

scholarly journals Association of the PLEKHO2 and PLEKHH1 gene polymorphisms with type 2 diabetic retinopathy in a Taiwanese population

ScienceAsia ◽  
2012 ◽  
Vol 38 (4) ◽  
pp. 340 ◽  
Author(s):  
Eric C. Han ◽  
Yu-Chuen Huang ◽  
Jane-Ming Lin ◽  
Hui-Ju Lin ◽  
Jer-Yuarn Wu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Taiwanese Population ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

2020 ◽  
Vol 1 (4) ◽  
pp. 229-233
Author(s):  
Pei-Pei Wu ◽  
◽  
Qing-Jing Wu ◽  
Cai-Xia Liu ◽  
Yun-Fei Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Diabetic Retinopathy ◽  
Regression Analysis ◽  
Proliferative Diabetic Retinopathy ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

AIM: To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and type 2 diabetic retinopathy (DR). METHODS: A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus (DM, n=100), non-proliferative diabetic retinopathy (NPDR, n=62) and proliferative diabetic retinopathy (PDR, n=38). 100 healthy persons were selected as the normal control group (NCG, n=100). The related indicators, such as neutrophil count, lymphocyte count and platelet count, were measured. RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group (1.81), DM group (1.76) and NPDR group (1.85) (P<0.05). The value of PLR was significantly higher in PDR group patients (126.18) than in DM group (111.64) (P<0.05). Logistic regression analysis showed that age (β= -0.047) was protective factor, course of diabetes (β=0.071) and systolic blood pressure (β=0.024) were risk factors for diabetic retinopathy (P<0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis. CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy

2008 ◽  
Vol 86 (4) ◽  
pp. 647-652 ◽  
Author(s):  
Jacek P. Szaflik ◽  
Ireneusz Majsterek ◽  
Michal Kowalski ◽  
Pawel Rusin ◽  
Anna Sobczuk ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Sorbitol Dehydrogenase ◽  
Dehydrogenase Gene ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy

2017 ◽  
Vol 19 (6-7) ◽  
pp. e2960 ◽  
Author(s):  
Rong Li ◽  
Peng Chen ◽  
Jing Li ◽  
Mengdan Yan ◽  
Jingjie Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy
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