Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy

2017 ◽  
Vol 19 (6-7) ◽  
pp. e2960 ◽  
Author(s):  
Rong Li ◽  
Peng Chen ◽  
Jing Li ◽  
Mengdan Yan ◽  
Jingjie Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

scholarly journals Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Suganthalakshmi Balasubbu ◽  
Periasamy Sundaresan ◽  
Anand Rajendran ◽  
Kim Ramasamy ◽  
Gowthaman Govindarajan ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Candidate Gene ◽  
Association Analysis ◽  
Gene Polymorphisms ◽  
Indian Patients ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

scholarly journals Association of the PLEKHO2 and PLEKHH1 gene polymorphisms with type 2 diabetic retinopathy in a Taiwanese population

ScienceAsia ◽  
2012 ◽  
Vol 38 (4) ◽  
pp. 340 ◽  
Author(s):  
Eric C. Han ◽  
Yu-Chuen Huang ◽  
Jane-Ming Lin ◽  
Hui-Ju Lin ◽  
Jer-Yuarn Wu ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Taiwanese Population ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy

2008 ◽  
Vol 86 (4) ◽  
pp. 647-652 ◽  
Author(s):  
Jacek P. Szaflik ◽  
Ireneusz Majsterek ◽  
Michal Kowalski ◽  
Pawel Rusin ◽  
Anna Sobczuk ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Gene Polymorphisms ◽  
Sorbitol Dehydrogenase ◽  
Dehydrogenase Gene ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Elevation in Circulating Soluble CD40 Ligand Concentrations in Type 2 Diabetic Retinopathy and Association with its Severity

2018 ◽  
Vol 128 (05) ◽  
pp. 319-324 ◽  
Author(s):  
Laila Ben Lamine ◽  
Amira Turki ◽  
Ghada Al-Khateeb ◽  
Nejla Sellami ◽  
Hagger B. Amor ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Linear Regression Analysis ◽  
Plasma Concentrations ◽  
Cd40 Ligand ◽  
Significant Finding ◽  
Characteristic Analysis ◽  
Soluble Cd40 Ligand ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Abstract Background To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). Subjects and methods sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients. Results Receiver operating characteristic analysis provided good discriminatory power for sCD40L as predictor of DR presence, with high sensitivity and specificity. Categorizing DWR and DR patients into sCD40L quartiles, based on sCD40L concentrations in T2DM without DR, demonstrated statistically significant gradual increase in DR risk with increasing sCD40L levels. sCD40L levels were significantly higher in DR compared to DWR patients. Plasma sCD40L levels differed significantly according to DR severity, and correlated with diabetes duration, dyslipedimea, nephropathy, and presence of DR, but not with gender, age, SBP, DBP, FPG, HbA1c, T2DM medications. Linear regression analysis confirmed the association of increased sCD40L levels with DR, independent of others parameters; mean plasma sCD40L levels differing significantly according to DR severity. Conclusion Plasma sCD40L levels were positively associated with DR. The significant finding here is that sCD40L levels can be predictors of DR severity.

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