scholarly journals The long non-coding RNA NEAT1 enhances epithelial-to-mesenchymal transition and chemoresistance via the miR-34a/c-Met axis in renal cell carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 62927-62938 ◽  
Author(s):  
Fei Liu ◽  
Na Chen ◽  
Yanchun Gong ◽  
Ruihai Xiao ◽  
Weichao Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA LOC648987 Promotes Proliferation and Metastasis of Renal Cell Carcinoma by Regulating Epithelial-Mesenchymal Transition

2021 ◽  
Vol 20 ◽  
pp. 153303382199783
Author(s):  
Yaowu Su ◽  
Liang Zhou ◽  
Qin Yu ◽  
Jianjun Lu ◽  
Wei Liu
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Negative Control ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Proliferation And Metastasis ◽  
Long Non Coding Rna

Renal cell carcinoma (RCC) is a type of urinary tumor with a high incidence and is often associated with tumor metastasis. Long non-coding RNA (lncRNA) regulates tumorigenesis, progression, and metastasis. However, the role and the predictive value of lncRNA in RCC progression and metastasis have not been elucidated. The purpose of this study was to evaluate the effect of a newly discovered lncRNA LOC648987 on RCC proliferation and metastasis. LOC648987 was identified by RT-PCR for high expression in human RCC tissues as well as in metastatic RCC tissues. In the cell experiments, we infected the RCC cell lines ACHN and 786-O cells with LOC648987-shRNA and its negative control (shNC). The results showed that the knockdown of LOC648987 inhibited the proliferation of ACHN and 786-O cells and colony formation. The cell cycle and the apoptosis progression of ACHN and 786-O cells were assessed using flow cytometry. The knockdown of LOC648987 significantly inhibited the progression of ACHN and 786-O cells from G0/G1 to S phase and promoted cell apoptosis. The metastasis promoting effects of LOC648987 on ACHN and 786-O cells were verified by transwell migration assays, which depended on vimentin and MMP-9 to regulate the epithelial–mesenchymal transition. Finally, the promotion of LOC648987 on RCC tumorigenesis was evaluated in BALb/c nude mice. These data confirmed that lncRNA LOC648987 promoted RCC cell proliferation and tumor metastasis and regulated the expression of EMT-related proteins in RCC cells.

scholarly journals TGF-β inducible epithelial-to-mesenchymal transition in renal cell carcinoma

Oncotarget ◽  
2019 ◽  
Vol 10 (15) ◽  
pp. 1507-1524 ◽  
Author(s):  
Sandy Tretbar ◽  
Peter Krausbeck ◽  
Anja Müller ◽  
Michael Friedrich ◽  
Christoforos Vaxevanis ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition

Abstract 3559: Long non-coding RNA subtype classification of clear-cell renal cell carcinoma

2014 ◽  
Author(s):  
Gabriel G. Malouf ◽  
Jianping Zhang ◽  
Nizar Tannir ◽  
Erika J. Thompson ◽  
David Khayat ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Subtype Classification ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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