scholarly journals High expression of the long non-coding RNA HEIRCC promotes Renal Cell Carcinoma metastasis by inducing epithelial-mesenchymal transition

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6555-6563 ◽  
Author(s):  
Jing Xiong ◽  
Ying Liu ◽  
Shengjun Luo ◽  
Li Jiang ◽  
Yang Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
High Expression ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Renal Cell Carcinoma Metastasis ◽  
Carcinoma Metastasis ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA LOC648987 Promotes Proliferation and Metastasis of Renal Cell Carcinoma by Regulating Epithelial-Mesenchymal Transition

2021 ◽  
Vol 20 ◽  
pp. 153303382199783
Author(s):  
Yaowu Su ◽  
Liang Zhou ◽  
Qin Yu ◽  
Jianjun Lu ◽  
Wei Liu
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Negative Control ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Proliferation And Metastasis ◽  
Long Non Coding Rna

Renal cell carcinoma (RCC) is a type of urinary tumor with a high incidence and is often associated with tumor metastasis. Long non-coding RNA (lncRNA) regulates tumorigenesis, progression, and metastasis. However, the role and the predictive value of lncRNA in RCC progression and metastasis have not been elucidated. The purpose of this study was to evaluate the effect of a newly discovered lncRNA LOC648987 on RCC proliferation and metastasis. LOC648987 was identified by RT-PCR for high expression in human RCC tissues as well as in metastatic RCC tissues. In the cell experiments, we infected the RCC cell lines ACHN and 786-O cells with LOC648987-shRNA and its negative control (shNC). The results showed that the knockdown of LOC648987 inhibited the proliferation of ACHN and 786-O cells and colony formation. The cell cycle and the apoptosis progression of ACHN and 786-O cells were assessed using flow cytometry. The knockdown of LOC648987 significantly inhibited the progression of ACHN and 786-O cells from G0/G1 to S phase and promoted cell apoptosis. The metastasis promoting effects of LOC648987 on ACHN and 786-O cells were verified by transwell migration assays, which depended on vimentin and MMP-9 to regulate the epithelial–mesenchymal transition. Finally, the promotion of LOC648987 on RCC tumorigenesis was evaluated in BALb/c nude mice. These data confirmed that lncRNA LOC648987 promoted RCC cell proliferation and tumor metastasis and regulated the expression of EMT-related proteins in RCC cells.

Renal cell carcinoma metastasis to thyroid tumor: a case report

2017 ◽  
Author(s):  
Carolina Faria ◽  
David Barbosa ◽  
Ana Sofia Osorio ◽  
Ema Nobre ◽  
Maria Joao Bugalho
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Thyroid Tumor ◽  
Renal Cell Carcinoma Metastasis ◽  
Carcinoma Metastasis

scholarly journals Significant association of interleukin 10 receptor mRNA levels with renal cell carcinoma metastasis

2008 ◽  
Vol 29 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Hideyuki ABE ◽  
Tomonori YAMANISHI ◽  
Tomoko MASHIDORI ◽  
Kyoko ARAI ◽  
Takao KAMAI
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Interleukin 10 ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Renal Cell Carcinoma Metastasis ◽  
Carcinoma Metastasis

scholarly journals TNF-α Induces Epithelial–Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism

2012 ◽  
Vol 10 (8) ◽  
pp. 1109-1119 ◽  
Author(s):  
Ming-Yi Ho ◽  
Shye-Jye Tang ◽  
Mei-Jen Chuang ◽  
Tai-Lung Cha ◽  
Jing-Yao Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Tnf Α ◽  
Dependent Mechanism
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