scholarly journals Dosimetric factors and Lyman normal-tissue complication modelling analysis for predicting radiation-induced lung injury in postoperative breast cancer radiotherapy: a prospective study

Oncotarget ◽  
2016 ◽  
Vol 8 (20) ◽  
pp. 33855-33863 ◽  
Author(s):  
Zhi-Rui Zhou ◽  
Qing Han ◽  
Shi-Xiong Liang ◽  
Xiao-Dong He ◽  
Nu-Yun Cao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Injury ◽  
Prospective Study ◽  
Normal Tissue ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Modelling Analysis ◽  
Radiation Induced ◽  
A Prospective Study

WHAT ANATOMIC FEATURES GOVERN PERSONAL LONG-TERM HEALTH RISKS FROM BREAST CANCER RADIOTHERAPY?

2019 ◽  
Vol 186 (2-3) ◽  
pp. 381-385
Author(s):  
Pavel Kundrát ◽  
Cristoforo Simonetto ◽  
Markus Eidemüller ◽  
Julia Remmele ◽  
Hannes Rennau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Risks ◽  
Individual Risk ◽  
Breast Cancer Patients ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Radiation Induced ◽  
Risk Variability ◽  
The Individual

Abstract Breast cancer radiotherapy may in the long term lead to radiation-induced secondary cancer or heart disease. These health risks hugely vary among patients, partially due to anatomy-driven differences in doses deposited to the heart, ipsilateral lung and contralateral breast. We identify four anatomic features that largely cover these dosimetric variations to enable personalized risk estimates. For three exemplary, very different risk scenarios, the given parameter set reproduces 63–74% of the individual risk variability for left-sided breast cancer patients. These anatomic features will be used in the PASSOS software to support decision processes in breast-cancer therapy.

Radiation-induced risk of ischemic heart disease following breast cancer radiotherapy in Denmark, 1977–2005

2020 ◽  
Vol 152 ◽  
pp. 103-110 ◽  
Author(s):  
Ebbe Laugaard Lorenzen ◽  
Jens Christian Rehammar ◽  
Maj-Britt Jensen ◽  
Marianne Ewertz ◽  
Carsten Brink
Keyword(s):  
Breast Cancer ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Radiation Induced

Dosimetric Evaluation of Critical Organs at Risk in Mastectomized Left-Sided Breast Cancer Radiotherapy Using Breath-Hold Technique

2013 ◽  
Vol 99 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Ferrat Dincoglan ◽  
Murat Beyzadeoglu ◽  
Omer Sager ◽  
Kaan Oysul ◽  
Yelda Elcim Kahya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Coronary Artery ◽  
Adjuvant Radiotherapy ◽  
Normal Tissue ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Breath Hold ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Tissue Sparing

Aims and background The aim of the study was to evaluate the dosimetric impact of the active breathing control-moderate deep inspiration breath-hold (ABC-mDIBH) technique on normal tissue sparing in locally advanced left-sided breast cancer radiotherapy. Methods and study design Twenty-seven consecutive patients with left-sided locally advanced breast cancer referred to our department for adjuvant radiotherapy were enrolled in the study. Each patient was scanned at free breathing and ABC-mDIBH for radiation treatment planning. Two separate radiotherapy treatment plans were generated with and without ABC-mDIBH to investigate the dosimetric impact of ABC-mDIBH in breast cancer radiotherapy. Results Between June 2011 and February 2012, 27 consecutive patients with left-sided locally advanced breast cancer referred to our department for adjuvant radiotherapy were enrolled in the study. Dose-volume parameters of left anterior descending coronary artery, lungs, heart, contralateral breast, esophagus and spinal cord were significantly reduced with the use of ABC-mDIBH ( P <0.001). Conclusions Our study revealed that the use of ABC-mDIBH in the practice of locally advanced mastectomized left-sided breast cancer radiotherapy improves normal tissue sparing with the expected potential of decreasing treatment-related morbidity and mortality. Moreover, the resultant reduction achieved with ABC in doses to the left anterior descending coronary artery, which plays a central role in cardiac perfusion, may have implications for decreasing the potential of radiation-induced cardiac morbidity and mortality.

Estimate of the risk of radiation-induced cancers after linear-accelerator-based breast-cancer radiotherapy

2013 ◽  
Vol 63 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Eui Kwan Koh ◽  
Jungju Seo ◽  
Tae Seong Baek ◽  
Eun Ji Chung ◽  
Myonggeun Yoon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Linear Accelerator ◽  
Cancer Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Radiation Induced
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