Inhibition of Acetylcolinesterase Enzyme from Pegagan Herb Extract (Centella asiatica), Kelor Leaf (Moringa oleifera) Extract and Combinations

2021 ◽  
Vol 7 (1) ◽  
pp. 33-36
2021 ◽  
Vol 50 (5) ◽  
pp. 1445-1456
Author(s):  
Nur Fatin Nabilah Mohd Sahardi ◽  
Faizul Jaafar ◽  
Siti Nor Asyikin Zakaria ◽  
Jen Kit Tan ◽  
Mariam Firdhaus Mad Nordin ◽  
...  

Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > á-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > á-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress.


2018 ◽  
Vol 42 ◽  
pp. 33-44 ◽  
Author(s):  
Elly Ezlinda ABDUL HISAM ◽  
Mohd Salleh ROFIEE ◽  
Aina Mardhia KHALID ◽  
Ahmad Firdaus JALALUDDIN ◽  
Mohd Izwan MOHAMAD YUSOF ◽  
...  

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
T Kaensaksiri ◽  
P Soontornchainaksaeng ◽  
N Soonthornchareonnon ◽  
S Prathanturarug
Keyword(s):  

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
A Alqahtani ◽  
W Tongkao-on ◽  
KM Li ◽  
V Razmovski-Naumovski ◽  
B Kimble ◽  
...  

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